Development of an oxygen-releasing electroconductive in-situ crosslinkable hydrogel based on oxidized pectin and grafted gelatin for tissue engineering applications

Nejati, Sara; Soflou, Reza Karimi; Khorshidi, Sajedeh; Karkhaneh, Akbar

doi:10.1016/j.colsurfb.2020.111347

Cited by 47 publications

(20 citation statements)

References 47 publications

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“…To remove any impurities, the solution obtained was dialyzed in acidic deionized water for 3 days using a dialysis bag with a molecular weight limit of 8000–14,000 Da. Dry GP was obtained after freeze-drying [ 29 , 54 ]. The chemical structure of GP was determined by 1 H NMR spectroscopy and Fourier transform infrared spectroscopy (FT-IR, Invenior, Bruker).…”

Section: Methodsmentioning

confidence: 99%

An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair

Zhang

et al. 2023

Bioactive Materials

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Section: Methodsmentioning

confidence: 99%

An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair

Zhang

et al. 2023

Bioactive Materials

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“…The final W 1 /O/W 2 emulsion was stirred at 300 rpm for 3 hours to complete solvent evaporation and microspheres hardening. The microspheres were washed with deionized water three times to remove residual PVA and H 2 O 2 , consequently, dried overnight under flowing air on a clean bench 16,17 …”

Section: Methodsmentioning

confidence: 99%

Influence of process parameters on the characteristics of oxygen‐releasing poly (lactic acid) microparticles: A multioptimization strategy

Nejati

Karimi‐Soflou

Karkhaneh

2020

Polymers for Advanced Techs

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Oxygen‐generating biomaterials have led to promising results in biomedical applications. Yet, the characteristics of these biomaterials need to meet the requirements of a specific application in order to be successful. In this study, hydrogen peroxide (H2O2) was used as the oxygen‐generating substance, and poly (l‐lactic acid) (PLLA) microparticles loaded with polyvinylpyrrolidone/hydrogen peroxide (PVP/H2O2) mixture were prepared using water‐in‐oil‐in‐water double emulsion technique. The experiments were carried out based on full factorial design where the impacts of PLLA concentration, H2O2:PVP molar ratio, and H2O2:organic phase volume ratio on microparticles' properties, including size, encapsulation efficiency, loading content, and percentage of initial burst release were assessed. Individual and multioptimization of responses were performed on the experimental data gained in the current study to investigate the effect of process parameters on the responses and fit the suitable model corresponding to the main and interactive effects. Recording both the H2O2 and O2 release of microparticles revealed that these profiles are also influenced by process variables, PLLA concentration in particular. These results enable accurate selection of optimal process variables for the fabrication of oxygen‐releasing PLLA microparticles with desirable characteristics for a wide variety of applications.

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“…e scaffold gains the advantages of electrical conductivity, injectability, compatibility, and continuous oxygen release [98].…”

Section: Scaffold For Tissuementioning

confidence: 99%

Advance of Electroconductive Hydrogels for Biomedical Applications in Orthopedics

Cao

Liu

Zhang

et al. 2021

Advances in Materials Science and Engineering

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Electroconductive hydrogels (EHs) are promising composite biomaterials of hydrogels and conductive electroactive polymers, incorporating bionic physicochemical properties of hydrogels and conductivity, electrochemistry, and electrical stimulation (ES) responsiveness of conductive electroactive polymers. The biomedical domain has increasingly seen EHs’ application to imitating the biological and electrical properties of human tissues, acclaimed as one of the most effective biomaterials. Bone’s complex bioelectrochemical properties and the corresponding stem cell differentiation affected by electrical signal elevate EHs’ application value in repairing and treating bone, cartilage, and skeletal muscle. Noteworthily, the latest orthopedic biological applications require broader information of EHs. Except for presenting the classification and synthesis of EHs, this review recapitulates the advance of EHs application to orthopedics in the past five years and discusses the pertinent development tendency and challenge, aiming to provide a reference for EHs application direction and prospect in orthopedic therapy.

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Development of an oxygen-releasing electroconductive in-situ crosslinkable hydrogel based on oxidized pectin and grafted gelatin for tissue engineering applications

Cited by 47 publications

References 47 publications

An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair

An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair

Influence of process parameters on the characteristics of oxygen‐releasing poly (lactic acid) microparticles: A multioptimization strategy

Advance of Electroconductive Hydrogels for Biomedical Applications in Orthopedics

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