A novel catalytic Fenton system based on H2 and the solid catalyst Pd/MIL-101(Cr) (MHACF-MIL-101(Cr)) was developed at normal temperature and pressure. In this system, the reduction process of FeIII back to FeII was accelerated significantly.
With the development of network technology, privacy protection and users anonymity become a new research hotspot. The existing blockchain privacy-aware public key infrastructure (PKI) model can ensure the privacy of users in the authentication process to a certain extent, but there are still problems of the storage and leakage of users' keys. This paper first proposes a strong forward-secure ring signature scheme based on RSA, which ensures the anonymity of the signing users and the forward-backward security of the keys. Then, by introducing the ring signature technology into the privacy-aware PKI model, this paper proposes a privacy-aware PKI model with strong forward security based on block chains, which not only ensures the users' identity privacy, but also solves the problem of the storage and leakage of the users' keys, greatly improving the success rate and security of the users' identity authentication. Finally, this paper applies the proposed PKI model to anonymous transactions, designs a privacy-aware anonymous transaction model with strong forward security, realizing anonymous transactions without relying on trusted third parties, and implementing users' privacy protection.
The development of an effective scaffold for bone defect repair is an urgent clinical need. However, it is challenging to design a scaffold with efficient osteoinduction and antimicrobial activity for regeneration of bone defect. In this study, we successfully prepared a hydroxyapatite (HA) porous scaffold with a surface-specific binding of peptides during osteoinduction and antimicrobial activity using a three-dimensional (3D) printing technology. The HA binding domain (HABD) was introduced to the C-terminal of bone morphogenetic protein 2 mimetic peptide (BMP2-MP) and antimicrobial peptide of PSI10. The binding capability results showed that BMP2-MP and PSI10-containing HABD were firmly bound to the surface of HA scaffolds. After BMP2-MP and PSI10 were bound to the scaffold surface, no negative effect was observed on cell proliferation and adhesion. The gene expression and protein translation levels of type I collagen (COL-I), osteocalcin (OCN) and Runx2 have been significantly improved in the BMP2-MP/HABP group. The level of alkaline phosphatase significantly increased in the BMP2-MP/HABP group. The inhibition zone test against Staphylococcus aureus and Escherichia coli BL21 prove that the PSI10/HABP@HA scaffold has strong antibacterial ability than another group. These findings suggest that 3D-printed HA scaffolds with efficient osteoinduction and antimicrobial activity represent a promising biomaterial for bone defect reconstruction.
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