Development of an integrated Monte Carlo model for glioblastoma multiforme treated with boron neutron capture therapy

Moghaddasi, Leyla; Bezak, Eva

doi:10.1038/s41598-017-07302-9

Cited by 10 publications

(19 citation statements)

References 54 publications

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“…Because the phantom in this experiment contained only pure water so the boron dose in this calculation is an evaluation for future work. Normally, the boron concentration ratio in tumor and normal tissue should be around 3.5 (Goorley et al 2002;Moghaddasi & Bezak 2017). Thus, in this study, the 10 B concentration is set at 12 ppm in the normal tissue and 42 ppm in the tumor.…”

Section: Resultsmentioning

confidence: 99%

Measurement of Neutron Flux and Gamma Dose Rate Distribution Inside a Water Phantom for Boron Neutron Capture Therapy Study at Dalat Research Reactor

Trinh¹,

Pham²,

Nhan³

et al. 2019

JSM

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Exposure dose rate to the tumor and surrounding cells during neutron beam irradiation in Boron Neutron Capture Therapy (BNCT) comes not only from heavy charged particles produced from the 10 B(n,α) 7 Li nuclear reaction, but also from neutron-induced reactions with other biological elements in living tissue, as well as from gamma rays leaked from the reactor core. At Dalat Research Reactor, Vietnam, the neutron and gamma dose rate distribution inside a water phantom were measured by using activation method and Thermoluminescent Dosimeter (TLD) detector, respectively. The results showed that effective thermal neutron dose rate along the center line of the water phantom had a maximum value of 479 mSv h -1 at 1 cm in phantom and then decreases rapidly to 4.87 mSv h -1 at 10 cm. The gamma dose rate along the center line of the water phantom also reach its maximum of 4.31 mSv h -1 at 1 cm depth and decreases to 1.16 mSv h -1 at 10 cm position. The maximum biological tumor dose rate was 1.74 Gy-eq h -1 , not high enough to satisfy the treatment requirement of brain tumors. However, the results of this work are important in supporting of BNCT study in the upcoming stages at Dalat Research Reactor. ABSTRAK Kadar dos pendedahan kepada tumor dan sel sekitarnya semasa pancaran sinaran neutron dalam Terapi Boron NeutronTertawan (BNCT) datang bukan sahaja daripada zarah berat bercas yang dihasilkan daripada tindak balas nuklear 10 B(n,α) 7 Li, tetapi juga daripada tindak balas neutron-teraruh daripada unsur biologi lain dalam tisu hidup, selain daripada sinar gama yang bocor daripada teras reaktor. Di Reaktor Penyelidikan Dalat, Vietnam, kadar pengagihan dos neutron dan gama dalam fantom air diukur masing-masing menggunakan kaedah pengaktifan dan pengesan Thermoluminescent Dosimeter (TLD). Keputusan menunjukkan bahawa kadar dos haba neutron yang berkesan sepanjang garis tengah fantom air mempunyai nilai maksimum 479 mSv h -1 pada 1 cm dalam phantom dan kemudian menurun dengan pantas kepada 4.87 mSv h -1 pada 10 cm. Kadar dos gama sepanjang garis tengah fantom air juga mencapai tahap maksimum 4.31 mSv h -1 pada kedalaman 1 cm dan menurun ke 1.16 mSv h -1 pada kedudukan 10 cm. Kadar dos maksimum tumor biologi adalah 1.74 Gy-eq h -1 namun tidak cukup tinggi untuk memenuhi keperluan rawatan tumor otak. Walau bagaimanapun, keputusan kajian ini adalah penting dalam menyokong pengajian BNCT pada peringkat akan datang di Reaktor Penyelidikan Dalat. Kata kunci: BNCT; fantom air; fluks haba neutron; kadar dos; pengesan TLD

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Section: Resultsmentioning

confidence: 99%

Measurement of Neutron Flux and Gamma Dose Rate Distribution Inside a Water Phantom for Boron Neutron Capture Therapy Study at Dalat Research Reactor

Trinh¹,

Pham²,

Nhan³

et al. 2019

JSM

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“…To this end, the use of combinatorial chemotherapy approaches to overcome chemoresistance is an emerging and promising approach. Similarly, several innovations in radiotherapy are focused on increasing radiosensitization [ 180 , 181 , 182 ]. If successful anti-invasive strategies can be developed, their application together with chemo- or radiotherapy may halt the progression of glioblastomas and, ultimately, prevent recurrence.…”

Section: Clinical Targeting Of Glioblastoma: Is There An Anti-invasion/anti-migration Treatment?mentioning

confidence: 99%

Tumor Cell Infiltration into the Brain in Glioblastoma: From Mechanisms to Clinical Perspectives

Seker-Polat

Degirmenci

Solaroğlu

et al. 2022

Cancers

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Glioblastoma is the most common and malignant primary brain tumor, defined by its highly aggressive nature. Despite the advances in diagnostic and surgical techniques, and the development of novel therapies in the last decade, the prognosis for glioblastoma is still extremely poor. One major factor for the failure of existing therapeutic approaches is the highly invasive nature of glioblastomas. The extreme infiltrating capacity of tumor cells into the brain parenchyma makes complete surgical removal difficult; glioblastomas almost inevitably recur in a more therapy-resistant state, sometimes at distant sites in the brain. Therefore, there are major efforts to understand the molecular mechanisms underpinning glioblastoma invasion; however, there is no approved therapy directed against the invasive phenotype as of now. Here, we review the major molecular mechanisms of glioblastoma cell invasion, including the routes followed by glioblastoma cells, the interaction of tumor cells within the brain environment and the extracellular matrix components, and the roles of tumor cell adhesion and extracellular matrix remodeling. We also include a perspective of high-throughput approaches utilized to discover novel players for invasion and clinical targeting of invasive glioblastoma cells.

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“…Monte-Carlo simulations are widely used for prediction of the behaviour of neutron generating facilities [9][10][11][12]. In our simulations, we applied the GEANT4 simulation package version 10.7.p01 [13].…”

Section: Geant4 Simulationsmentioning

confidence: 99%

Evaluation of depth-dose profiles in a water phantom at the BNCT facility at BINP

et al. 2021

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In this study, we present depth-dose profiles measured with a water phantom at the boron neutron-capture therapy (BNCT) facility at Budker Institute of Nuclear Physics (BINP). The presented results demonstrate that the proposed design of radiation detector with an optical fiber readout, which includes three different sensors (the first based on a plastic scintillator enriched with boron, the second based on a simple plastic scintillator, and the third having no scintillator at all), enables measurement of neutron flux, as well as estimations of the dose induced by gamma rays. The results of simulations with the GEANT4 package demonstrated good agreement with the experimental data and can be used for further system improvement.

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Development of an integrated Monte Carlo model for glioblastoma multiforme treated with boron neutron capture therapy

Cited by 10 publications

References 54 publications

Measurement of Neutron Flux and Gamma Dose Rate Distribution Inside a Water Phantom for Boron Neutron Capture Therapy Study at Dalat Research Reactor

Measurement of Neutron Flux and Gamma Dose Rate Distribution Inside a Water Phantom for Boron Neutron Capture Therapy Study at Dalat Research Reactor

Tumor Cell Infiltration into the Brain in Glioblastoma: From Mechanisms to Clinical Perspectives

Evaluation of depth-dose profiles in a water phantom at the BNCT facility at BINP

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