Development of an injectable composite as a carrier for growth factor‐enhanced periodontal regeneration

Abstract

Characteristics of the PLGA composite makes it an attractive matrix to support native wound healing and rhGDF-5-enhanced periodontal regeneration.

Wound healing/regeneration using recombinant human growth/differentiation factor-5 in an injectable poly-lactide-co-glycolide-acid composite carrier and a one-wall intra-bony defect model in dogs

“…The rhGDF‐5/PLGA construct significantly increased bone and cementum formation in a dose‐dependent order in the absence of root resorption/ankylosis. To fully appreciate the effectiveness of rhGDF‐5 on periodontal wound healing/regeneration, biocompatible, biodegradable carriers, preferably synthetic should be used; carrier prerequisites including porosity for optimized cell ingrowth, space provision, and provision(s) for clot/wound stabilization have been emphasized (Polimeni et al 2006, Herberg et al 2008). Recent studies have shown that rhGDF‐5 soak loaded onto an absorbable collagen sponge carrier (rhGDF‐5/ACS) or adsorbed onto micro/macro‐porous β ‐TCP particles (rhGDF‐5/ β ‐TCP) significantly enhances periodontal wound healing/regeneration compared with sham‐surgery, carrier, and benchmark (rhPDGF/ β ‐TCP) controls (Kim et al 2009, Kwon et al 2010c, Lee et al 2010b).…”

“…However, both the ACS and β ‐TCP carrier technologies are limited to inlay indications. The ease‐of‐use rhGDF‐5/PLGA composite construct herein is intended for inlay and onlay indications as well as minimally invasive procedures (Herberg et al 2008, Pompe 2008). A previous study, which focused on handling logistics, showed that the injectable rhGDF‐5/PLGA construct offered a simple predicable application to subgingival sites using a non‐critical‐size defect model (Kwon et al 2010a).…”

“…The novel rhGDF‐5/PLGA construct (Scil Technology GmbH, Martinsried, Germany) consisted of rhGDF‐5 in an injectable bioresorbable PLGA composite carrier (Herberg et al 2008, Pompe 2008). To avoid incompatibilities between the active drug and the carrier, the two components were supplied separately.…”

Alveolar Augmentation: Focus on Growth Factors (BMPs)

“…They should be injectable for ease-of-use implantable and minimally invasive approaches; they should be space-providing allowing structurally integrity/wound stability for a regenerate to form also in noncontained sites (onlay indications); they should be macroporous for rapid ingrowth of cells and vascular support from adjoining tissue resources; they should allow appropriate release/bioavailability of the biologic; and they should feature a biodegradation profile/rapid clearance allowing the regenerate uneventful maturation (Herberg et al 2008). …”

Biomaterial Selection for Tooth Regeneration

“…92 Subsequently, this PLGA hydrogel was applied with recombinant human growth differentiation factor-5 (rhGDF-5) in periodontal defects in a dog model. 93 Periodontal pockets (3 · 6 mm, width · depth) are surgically created over the buccal roots of the second and fourth mandibular premolars in mongrel dogs.…”