Development of an improved method for the determination of polycyclic aromatic hydrocarbons in mainstream tobacco smoke

Tarrant, John E.; Mills, Kevin; Williard, C. S.

doi:10.1016/j.chroma.2009.01.009

Cited by 21 publications

(15 citation statements)

References 11 publications

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“…After an SPE clean-up step (Florisil Ò SEP-PAK), samples were analyzed by GC-MS in SIM mode using negative chemical ionization. PAH analysis was conducted by extraction in MEOH followed by SPE clean-up and analysis by GC-MS in SIM mode (Tarrant et al, 2009).…”

Section: Analytical Assaysmentioning

confidence: 99%

Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air

Tayyarah¹,

Long²

2014

Regulatory Toxicology and Pharmacology

217

172

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Leading commercial electronic cigarettes were tested to determine bulk composition. The e-cigarettes and conventional cigarettes were evaluated using machine-puffing to compare nicotine delivery and relative yields of chemical constituents. The e-liquids tested were found to contain humectants, glycerin and/or propylene glycol, (⩾75% content); water (<20%); nicotine (approximately 2%); and flavor (<10%). The aerosol collected mass (ACM) of the e-cigarette samples was similar in composition to the e-liquids. Aerosol nicotine for the e-cigarette samples was 85% lower than nicotine yield for the conventional cigarettes. Analysis of the smoke from conventional cigarettes showed that the mainstream cigarette smoke delivered approximately 1500times more harmful and potentially harmful constituents (HPHCs) tested when compared to e-cigarette aerosol or to puffing room air. The deliveries of HPHCs tested for these e-cigarette products were similar to the study air blanks rather than to deliveries from conventional cigarettes; no significant contribution of cigarette smoke HPHCs from any of the compound classes tested was found for the e-cigarettes. Thus, the results of this study support previous researchers' discussion of e-cigarette products' potential for reduced exposure compared to cigarette smoke.

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Section: Analytical Assaysmentioning

confidence: 99%

Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air

Tayyarah¹,

Long²

2014

Regulatory Toxicology and Pharmacology

217

172

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“…Many published methods require the collection of cigarette smoke condensate from several to as many as 20 cigarettes. Theoretically, increasing the amount of analytes present in the sample can increase the method sensitivity; however, it also increases the concentration of matrix interference substances . An advantage of the method proposed here over formerly published methods is that it is sensitive enough to quantify PAHs in cigarette mainstream smoke from only one cigarette, while maintaining good reproducibility and accuracy, even for trace amounts of PAHs (such as for BkFlu, Dibaha, and Bghip).…”

Section: Resultsmentioning

confidence: 98%

“…PAHs have been classified as possible or probable human carcinogens by the International Agency for Research on Cancer, based on either sufficient or limited evidence . Among the known PAHs, 16 substances in this class are considered priority, and they were found in cigarette mainstream smoke . Therefore, methods for the rapid and sensitive quantitation of PAHs in cigarette smoke condensate (CSC) can play an important role in evaluating their potential risks.…”

Section: Introductionmentioning

confidence: 99%

“…Methods for the measurement of PAHs in CSC have employed HPLC , GC , and GC–MS , among other technologies. However, HPLC methods often involve large‐scale solvent extractions and time‐consuming steps such as saponification and LLEs .…”

Section: Introductionmentioning

confidence: 99%

“…Further, the sensitivity and selectivity of these methods were relatively low, and these methods were sensitive to disturbance from impurities. GC–MS has been applied in PAHs analysis. For less volatile PAHs, it is necessary to carry out the derivatization step, which increases the analysis time and makes the sample preparation more complicated.…”

Section: Introductionmentioning

confidence: 99%

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Quantification of 16 polycyclic aromatic hydrocarbons in cigarette smoke condensate using stable isotope dilution liquid chromatography with atmospheric-pressure photoionization tandem mass spectrometry

et al. 2015

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A stable isotope dilution liquid chromatography tandem mass spectrometry method for the analysis of 16 polycyclic aromatic hydrocarbons in cigarette smoke condensate was developed and validated. Compared with previously reported methods, this method has lower limits of detection (0.04-1.35 ng/cig). Additionally, the proposed method saves time, reduces the number of separation steps, and reduces the quantity of solvent needed. The new method was applied to evaluate polycyclic aromatic hydrocarbon content in 213 commercially available cigarettes in China, under the International Standardization Organization smoking regime and the Health Canadian intense smoking regime. The results showed that the total polycyclic aromatic hydrocarbon content was more than two times higher in samples from the Health Canadian intense smoking regime than in samples from the International Standardization Organization smoking regime (1189.23 versus 2859.50 ng/cig, p < 0.05). Meanwhile, the concentration of individual polycyclic aromatic hydrocarbons (and total polycyclic aromatic hydrocarbons) increased with labeled tar content in both of the tested smoking regimes. There was a positive correlation between total polycyclic aromatic hydrocarbons under the International Standardization Organization smoking regime with that under the Health Canadian intense smoking regime. The proposed liquid chromatography tandem mass spectrometry method is satisfactory for the rapid, sensitive, and accurate quantitative evaluation of polycyclic aromatic hydrocarbon content in cigarette smoke condensate, and it can be applied to assess potential health risks from smoking.

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Current Awareness in Drug Testing and Analysis

2009

Drug Testing and Analysis

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of drug testing and analysis. Each bibliography is divided into 18 sections: 1 Reviews; 2 Sports doping ‐ General; 3 Steroids; 4 Peptides; 5 Diuretics; 6 CNS agents; 7 Equine; 8 Recreational drugs ‐ General; 9 Stimulants; 10 Hallucinogens; 11 Narcotics; 12 Forensics; 13 Alcohol; 14 Tobacco; 15 Homeland security; 16 Workplace; 17 Product authenticity; 18 Techniques. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Development of an improved method for the determination of polycyclic aromatic hydrocarbons in mainstream tobacco smoke

Cited by 21 publications

References 11 publications

Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air

Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air

Quantification of 16 polycyclic aromatic hydrocarbons in cigarette smoke condensate using stable isotope dilution liquid chromatography with atmospheric-pressure photoionization tandem mass spectrometry

Current Awareness in Drug Testing and Analysis

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