Development of an Impression Material with Antimicrobial Properties for Dental Application

Abstract

Purpose To evaluate the antimicrobial activity and physico‐mechanical properties of an irreversible hydrocolloid in which nanostructured silver vanadate decorated with silver nanoparticles (AgVO3) was added at various concentrations (0% ‐ control, 2.5%, 5%, and 10% by weight). Materials and Methods The agar diffusion method (n = 10) was used to evaluate the inhibitory effect on the following species: Streptococcus mutans, Staphyloccocus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. The gelation time, flow capacity and plastic deformation were verified (n = 10). The data were analyzed using the Kruskal‐Wallis test followed by the Dunn post‐test, or via one‐way ANOVA with multiple comparisons with a Bonferroni adjustment depending on the distribution (α = 0.05). Results All percentages of the nanomaterial were able to promote the antimicrobial activity of a hydrocolloid, with the formation of an inhibition zone (p < 0.05). In general, there was a dose‐dependent effect on antimicrobial activity: higher concentrations of the nanomaterial promoted greater action except in the cases of P. aeruginosa (p < 0.001; F = 51.74) and S. aureus (p < 0.001), where the highest inhibition was for the 2.5% group. No difference was found in the gelation time when the control was compared with the groups with AgVO3 (p > 0.05). The difference was between the 5% and 10% groups (p = 0.007), and the latter promoted an increase in time. The flow capacity of the hydrocolloid with 5% of AgVO3 was significantly lower when compared with the control (p = 0.034). The AgVO3 influenced the plastic deformation (p < 0.001) in such a way that concentrations of 5% (p = 0.010) and 10% (p < 0.001) promoted an increase in this property when compared with the control. Conclusions AgVO3 can be incorporated into an irreversible hydrocolloid as an antimicrobial agent without promoting adverse effects on physical‐mechanical properties when used in concentrations of 2.5%.

Nanostructured silver vanadate decorated with silver particles and their applicability in dental materials: A scope review

“…Several studies have evaluated the effect of the incorporation of nanostructured silver vanadate decorated with silver particles to endodontic cement [ 14 , 18 , 19 , 20 , 21 ]. Teixeira et al., 2019 [ 20 ] found that after modifying sealer, Endomethasone N and AH-Plus endodontic cement with the addition of 2.5, 5 and 10% β-AgVO 3 , there was better inhibition for the groups of 5 and 10% for Sealer, 2.5, 5 and 10% for Endomethasone, while AH-Plus presented similar results to the control group.…”

“…De Castro et al., 2019 [ 21 ] evaluated the effect of the incorporation of β-AgVO 3 in 2.5, 5 and 10% in an irreversible hydrocolloid and obtained results that the addition demonstrated antimicrobial effects and dependent dose, except for P. aeruginosa and Streptococcus aureus. Regarding the time of gelatinization of the material, there were no significant differences in relation to the control group.…”

“…The results showed that the incorporation was successfully performed, evidencing the antimicrobial activity of β-AgVO 3 differing from the control groups studied that did not present the incorporation. The largest number of studies was the incorporation of β-AgVO 3 into acrylic resin, contemplating 6 studies of the present review [ 7 , 9 , 10 , 15 , 16 , 17 ], followed by 5 studies that presented the incorporation in endodontic cement [ 12 , 14 , 18 , 19 , 20 ], 1 in irreversible hydrocolloid [ 21 ], 1 in soft denture liner for prostheses [ 22 ], 1 in substrates that can be used for dental implant surface [ 11 ], 1 in ceramics [ 13 ] ( Figure 2 ). The studies that presented a single specimen hinder the evaluation and possible divergence between authors regarding the difference of results regarding the incorporation in these specimens.…”

“…The release of Ag + and V 4+ /V 5+ was proportional to the concentration of AgVO 3 incorporated in the sealers. De Castro et al., 2019 [ 21 ]. Irreversible hydrocolloid.…”

Influence of modification of dental porcelains with hybrid nanomaterial on surface characteristics, antimicrobial, chemical, and mechanical properties

“…In dentistry, the β-AgVO 3 was incorporated in several dental materials such as acrylic resins, denture liners, impression materials, endodontic sealers, and prosthetic components, and demonstrated antimicrobial activity against Streptococcus mutans, Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis and Escherichia coli [12][13][14][15][16][17][18][19].…”