Development of an HPLC Method for Identification and Quantification of Anti-leishmaniasis Drug Candidate NFOH After Oral Administration of NLC-NFOH in Rats

Souza, Aline de; Almeida, Maria Karilly Lima de; Barbosa, João Antonio; Yukuyama, Megumi Nishitani; Correia, Cristiano de Jesus; Breithaupt‐Faloppa, Ana Cristina; Bou‐Chacra, Nádia Araci; Calixto, Leandro Augusto

doi:10.1007/s42250-022-00547-6

Chemistry Africa

2022

DOI: 10.1007/s42250-022-00547-6

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Development of an HPLC Method for Identification and Quantification of Anti-leishmaniasis Drug Candidate NFOH After Oral Administration of NLC-NFOH in Rats

Aline de Souza

Maria Karilly Lima de Almeida

João Antonio Barbosa

et al.

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2024

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Hydroxymethylnitrofurazone Lymphatic Uptake with Nanostructured Lipid Carrier After Oral Administration in Rats

Souza,

Scarim,

Cotrim

et al. 2024

Nanomedicine (Lond.)

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Background: Leishmaniasis, caused by the protozoan Leishmania sp., infects phagocyte cells present in lymphatic organs. This study demonstrates the influence of nanostructured lipid carrier-loaded hydroxymethylnitrofurazone (NLC-NFOH) on lymphatic uptake using a chylomicron-blocking flow model in rats. Method: Lymphatic uptake of NFOH was assessed 1 h after oral administration of dimethyl sulfoxide with NFOH or NLC-NFOH with and without cycloheximide pretreatment. Result: Dimethyl sulfoxide with NFOH and NLC-NFOH showed NFOH serum concentrations of 0.0316 and 0.0291 μg/ml, respectively. After chylomicron blocking, NFOH was not detected. Conclusion: Despite log P below 5, NFOH was successfully taken up by the lymphatic system. Long-chain fatty acids and particle size might be main factors in these findings. NLC-NFOH is a promising and convenient platform for treating leishmaniasis via oral administration.

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Hydroxymethylnitrofurazone Lymphatic Uptake with Nanostructured Lipid Carrier After Oral Administration in Rats

Souza,

Scarim,

Cotrim

et al. 2024

Nanomedicine (Lond.)

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Development of an HPLC Method for Identification and Quantification of Anti-leishmaniasis Drug Candidate NFOH After Oral Administration of NLC-NFOH in Rats

Cited by 1 publication

References 25 publications

Hydroxymethylnitrofurazone Lymphatic Uptake with Nanostructured Lipid Carrier After Oral Administration in Rats

Hydroxymethylnitrofurazone Lymphatic Uptake with Nanostructured Lipid Carrier After Oral Administration in Rats

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