Hydroxymethylnitrofurazone Lymphatic Uptake with Nanostructured Lipid Carrier After Oral Administration in Rats
Aline de Souza,
Cauê Benito Scarim,
Paulo Cesar Cotrim
et al.
Abstract:Background: Leishmaniasis, caused by the protozoan Leishmania sp., infects phagocyte cells present in lymphatic organs. This study demonstrates the influence of nanostructured lipid carrier-loaded hydroxymethylnitrofurazone (NLC-NFOH) on lymphatic uptake using a chylomicron-blocking flow model in rats. Method: Lymphatic uptake of NFOH was assessed 1 h after oral administration of dimethyl sulfoxide with NFOH or NLC-NFOH with and without cycloheximide pretreatment. Result: Dimethyl sulfoxide with NFOH and NLC-N… Show more
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