Development of an experimental model to study trigeminal nerve-mediated vasodilation on the human forehead

Ibrahimi, Khatera; Vermeersch, Steve; Danser, A.H. Jan; Cm, Villalón; Meiracker, AH van den; Hoon, Jan de; MaassenVanDenBrink, Antoinette

doi:10.1177/0333102413517773

Cited by 16 publications

(24 citation statements)

References 39 publications

(54 reference statements)

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“…However, it has been suggested that the absence of a DBF response may be purely related to insufficient skin penetration rather than to the absence of (functional) TRPV1 channels. This was supported by the observation that subjects with an apparently absent response to capsaicin applied on the forearm do respond after application on the forehead skin (43).…”

Section: Discussionmentioning

confidence: 82%

The influence of migraine and female hormones on capsaicin-induced dermal blood flow

et al. 2016

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Background Migraine is much more common in females than in males, and occurrence is associated with changes in female sex hormones. Calcitonin gene-related peptide (CGRP) plays a key role in migraine, and variations in female sex hormones may affect CGRP sensitivity and/or production. Objectives Investigate repeatability, gender differences, influence of the menstrual cycle and of migraine on CGRP-dependent changes in dermal blood flow (DBF). Methods CGRP-dependent increases in DBF were assessed using laser Doppler perfusion imaging after topical application of 300 or 1000 µg capsaicin on the forearm of healthy subjects and migraine patients. Results In healthy males, DBF response did not vary over time and was comparable with DBF in male migraineurs. In healthy females, capsaicin-induced DBF responses to both doses of capsaicin were higher during menstruation compared to the late-secretory phase (p < 0.05); this menstrual cycle dependence was absent in female migraine patients. Compared to healthy subjects, female migraineurs displayed a higher DBF response both during menstruation and during the late-secretory phase (p < 0.05). Conclusions An increased capsaicin-induced, CGRP-mediated DBF response was observed during menstruation in healthy women, but in female migraine patients this increased response was not affected by the menstrual cycle.

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Section: Discussionmentioning

confidence: 82%

The influence of migraine and female hormones on capsaicin-induced dermal blood flow

et al. 2016

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“…39 In a similar manner, capsaicin and saline applied to the human forehead, with and without iontophoresis, led to an immediate increase in dermal blood flow. 40 …”

Section: Discussionmentioning

confidence: 99%

Bulbar conjunctival microvascular responses in dry eye

et al. 2017

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Purpose Conjunctival microvascular responses may be a surrogate metric of efferent neural pathway function innervating the ocular surface as changes in blood flow occur within seconds after a stimulus. As somatosensory dysfunction may partially underlie dry eye (DE), in this study we evaluate whether bulbar conjunctival microvascular alterations correlate with various aspects of DE. Methods Fifty-six DE patients were prospectively recruited from a Veterans Affairs ophthalmology clinic over an 11-month period. DE symptoms and ocular pain were assessed along with DE signs. A novel functional slit lamp biomicroscope (FSLB) was used to image the temporal bulbar conjunctiva from the right eye before and after central corneal stimulation with an air puff. Blood flow velocities were measured and noninvasive microvascular perfusion maps (nMPMs) were created. Results The bulbar blood flow velocity was 0.50±0.15 mm/s at baseline and increased to 0.55±0.17 mm/s after stimulation (P<0.001); the average change in velocity was 0.05±0.09. nMPMs values and venule diameter, on the other hand, did not significantly increase after stimulation (1.64±0.004 at baseline, 1.65±0.04 after stimulation, P=0.22 and 22.13±1.84 m at baseline, 22.21±2.04 μm after stimulation, P=0.73, respectively). Baseline blood flow velocity positively associated with Schirmer scores (r=0.40, P=0.002). Those with higher self-rated wind hyperalgesia demonstrated less change in blood flow velocity (r= −0.268, P=0.046) after air stimulation on the central cornea. Conclusion Conjunctival blood flow velocity, but not vessel diameter or complexity, increases after wind stimuli. Baseline flow positively correlated with Schirmer scores while change in flow negatively correlated with self-reported wind hyperalgesia.

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“…An optimization of the previous model was done by studying a dermatome in the human forehead innervated by the frontal branch of the ophthalmic (V 1 ) nerve, where the increase in dermal blood flow is produced by trigeminal nerve activation via topical capsaicin application or electrical stimulation of the forehead skin (64).…”

Section: Is There a Gender Difference In The Functionality Of Cgrp Anmentioning

confidence: 99%

Gender aspects of CGRP in migraine

et al. 2017

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Background: Migraine is two to three times more prevalent in women than in men, but the mechanisms involved in this gender disparity are still poorly understood. In this respect, calcitonin gene-related peptide (CGRP) plays a key role in migraine pathophysiology and, more recently, the functional interactions between ovarian steroid hormones, CGRP and the trigeminovascular system have been recognized and studied in more detail. Aims: To provide an overview of CGRP studies that have addressed gender differences utilizing animal and human migraine preclinical research models to highlight how the female trigeminovascular system responds differently in the presence of varying ovarian steroid hormones. Conclusions: Gender differences are evident in migraine. Several studies indicate that fluctuations of ovarian steroid hormone (mainly estrogen) levels modulate CGRP in the trigeminovascular system during different reproductive milestones. Such interactions need to be considered when conducting future animal and human experiments, since these differences may contribute to the development of gender-specific therapies.

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Development of an experimental model to study trigeminal nerve-mediated vasodilation on the human forehead

Abstract: Topical application of capsaicin and electrical stimulation induce reproducible forehead DBF increases and therefore are suitable to study trigeminal nerve-mediated vasodilation in humans.

Cited by 16 publications

References 39 publications

The influence of migraine and female hormones on capsaicin-induced dermal blood flow

The influence of migraine and female hormones on capsaicin-induced dermal blood flow

Bulbar conjunctival microvascular responses in dry eye

Gender aspects of CGRP in migraine

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