Development of an animal model for neuroleptic malignant syndrome: heat-exposed rabbits with haloperidol and atropine administration exhibit increased muscle activity, hyperthermia, and high serum creatine phosphokinase level

Tanii, Hisashi; Taniguchi, N; Niigawa, Hisayoshi; Hosono, Takayoshi; Ikura, Yuji; Sakamoto, Sakae; Kudo, Takashi; Nishimura, Tsuyoshi; Takeda, Masatoshi

doi:10.1016/s0006-8993(96)01059-1

Cited by 22 publications

(11 citation statements)

References 20 publications

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“…Rabbits treated with haloperidol and exposed to high ambient temperature may be useful in elucidating the pathogenesis of NMS. 46 Molecular basis of NMS The molecular basis for NMS is unclear, but studies suggest that genetic factors are involved in its pathogenesis. 27 Involvement of the serotonergic system in NMS has been suggested, but polymorphisms in the 5-HT1A and 5-HT2A receptor genes do not determine susceptibility to NMS.…”

Section: Direct Toxic Effect On Skeletal Muscle Induced By Neurolepticsmentioning

confidence: 99%

Neuroleptic malignant syndrome

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Lestavel

Krivosic-Horber

2000

British Journal of Anaesthesia

257

242

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Section: Direct Toxic Effect On Skeletal Muscle Induced By Neurolepticsmentioning

confidence: 99%

Neuroleptic malignant syndrome

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Lestavel

Krivosic-Horber

2000

British Journal of Anaesthesia

257

242

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“…The exact mechanism of NMS is unknown. In an animal model of NMS, increase in muscle activity causes rigidity and rise in serum CPK levels [7]. We suggest that, in our case, muscle contraction and rigidity were initially inhibited by the concomitant hypotonia, resulting in a delayed serum CPK rise.…”

Section: Discussionmentioning

confidence: 54%

Neuroleptic Malignant Syndrome with Hypotonia: A Diagnostic Challenge

Korn‐Lubetzki¹,

Gottlieb

2001

Eur Neurol

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“…Acredita-se que ela se deva a bloqueio dos receptores dopaminérgicos nos gânglios da base, fato este que deu origem à sinonímia de síndrome da deficiência aguda de dopamina 3,9,15 . Tanii e col. descreveram modelo animal baseado em coelhos expostos ao calor após administração de haloperidol e atropina, na tentativa de melhor compreender a etiopatogenia e avaliar os tratamentos disponíveis para síndrome 21 .…”

Section: Discussionunclassified

Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina

Hanel¹,

Sandmann²,

Kranich³

et al. 1998

Arq. Neuro-Psiquiatr.

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RESUMO -A síndrome neuroléptica maligna (SNM) consiste em reação idiossincrática a neurolépticos, provavelmente relacionada a bloqueio dos receptores dopaminérgicos nos gânglios da base, sendo por isso também conhecida como síndrome da deficiência aguda de dopamina.A SNM é caracterizada por hiperpirexia, alteração do nível de consciência, hipertonia, disfunção autonômica e insuficiência respiratória, podendo ainda ser encontrados rabdomiólise e leucocitose. O haloperidol é a droga mais frequentemente associada à síndrome. Relatamos o caso de um paciente de 30 anos que apresentou SNM em duas ocasiões diferentes, a primeira delas relacionada ao uso de haloperidol e clorpromazina e a segunda relacionada ao uso de olanzapina, fato este sem menção anterior na literatura indexada.PALAVRAS-CHAVE: síndrome neuroléptica maligna, haloperidol, clorpromazina, olanzapina, dantrolene, bromocriptina. Neuroleptic malignant syndrome: case report of a recurrence related to olanzapineABSTRACT -The neuroleptic malignant syndrome (NMS) consists in an idiosyncratic reaction to neuroleptic drugs, probably related to a blockage of dopamine receptors in basal ganglia. Research criteria for diagnosing NMS from DSM-IV require severe rigidity and fever accompanied by 2 of 10 minor features including diaphoresis, dysphagia, tremor, incontinence, altered mentation, mutism, tachycardia, elevated or labile blood pressure, leukocytosis and elevation of creatine phosphokinase. From a clinical point of view, the NMS may range a large spectrum of presentations. Haloperidol is the most frequent drug associated with this syndrome. We report the case of a 30 year-old man who developed NMS at two different occasions, the first related to haloperidol and chlorpromazine and the second related to olanzapine, to our knowledge without previous mention in the indexed literature.

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Development of an animal model for neuroleptic malignant syndrome: heat-exposed rabbits with haloperidol and atropine administration exhibit increased muscle activity, hyperthermia, and high serum creatine phosphokinase level

Cited by 22 publications

References 20 publications

Neuroleptic malignant syndrome

Neuroleptic malignant syndrome

Neuroleptic Malignant Syndrome with Hypotonia: A Diagnostic Challenge

Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina

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