Development of an Analytical Method for Strong Mutagens/Carcinogens, 3,9-Dinitrofluoranthene and Dinitropyrene Isomers, in the Environment and Their Particle-Size Distribution in Airborne Particles

Hasei, Tomohiro; Sakaguchi, Masumi; Yoneda, Maki; Wada, Mitsuhiro; Miyagawa, Shuhei; Kobayashi, Kana; Fukuda, Takashi; Arita, Saori; Ikemori, Fumikazu; Watanabe, Tetsushi

doi:10.1007/s10337-014-2817-3

Cited by 5 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…× 250 mm, Nacalai Tesque) to clean up NPAHs. 19) NPAHs were analyzed as corresponding amino compounds with a two-dimensional HPLC system using the first separation column (Inertsil ODS-EP column (4.6 mm i.d. × 250 mm, GL Science, Tokyo, Japan)), a concentration column (COSMOSIL 5C18-AR-II column (4.6 mm i.d.…”

Section: Quantification Of Pahs and Npahsmentioning

confidence: 99%

Comparison of Air Pollution in Metropolises in China (Beijing) and Japan (Osaka and Nagoya) on the Basis of the Levels of Contaminants and Mutagenicity

Coulibaly

Minami

Abe

et al. 2016

Biological & Pharmaceutical Bulletin

Self Cite

View full text Add to dashboard Cite

Public concern regarding the transport of air pollutants from mainland East Asia to the leeward area by the prevailing westerlies in spring and winter monsoon has been growing in recent years. We collected total suspended particle (TSP) in Beijing, a metropolis of China located windward of Japan, in spring (late February 2011-May 2011) and in winter (November 2012-early February 2013), then analyzed metals, ions, and organic compounds and mutagenicity, and compared the pollution levels with samples collected at two Japanese metropolises (Osaka and Nagoya) during the same periods. The medians of concentration of TSP and other factors in Beijing were much larger than those in the Japanese metropolises. Especially, the concentrations of polycyclic aromatic hydrocarbons (PAHs) were remarkably high in Beijing in winter, and the median of total PAHs concentration in Beijing was 62-63 times larger than that in the Japanese sites. The mutagenicity of TSP from Beijing toward Salmonella typhimurium YG1024, with and without a mammalian metabolic system (S9 mix), was 13-25 times higher than that from the Japanese sites in winter. These results suggest that air pollution levels in Beijing are very high compared with those at the two Japanese metropolises we evaluated. The diagnostic ratios of PAHs and nitrated polycyclic aromatic hydrocarbons (NPAHs) suggest that the major sources of PAHs and NPAHs in Beijing are different from those at the two Japanese sites in winter, and that the major source in Beijing is coal/biomass combustion.

show abstract

Section: Quantification Of Pahs and Npahsmentioning

confidence: 99%

Comparison of Air Pollution in Metropolises in China (Beijing) and Japan (Osaka and Nagoya) on the Basis of the Levels of Contaminants and Mutagenicity

Coulibaly

Minami

Abe

et al. 2016

Biological & Pharmaceutical Bulletin

Self Cite

View full text Add to dashboard Cite

show abstract

“…Aliquots of the organic extracts were submitted to the cleanup process described by Hasei et al (2015) prior to the analysis of the seven selected nitro-PAHs congeners. Nitro-PAHs were analyzed according to Coulibaly et al (2016).…”

Section: Nitro-pah Analysismentioning

confidence: 99%

Similar polycyclic aromatic hydrocarbon and genotoxicity profiles of atmospheric particulate matter from cities on three different continents

Maselli

Cunha

Lim

et al. 2020

Environ and Mol Mutagen

Self Cite

View full text Add to dashboard Cite

The extractable organic material (EOM) from atmospheric total suspended particles (TSP) contains several organic compounds including non‐substituted polycyclic aromatic hydrocarbons (PAHs), alkyl‐PAHs, and nitro‐PAHs. These chemicals seem to be among the key drivers of TSP genotoxicity. We have shown previously that the mutagenic potencies of the EOM from Limeira, Stockholm, and Kyoto, cities with markedly different meteorological conditions and pollution sources are similar. Here we compare the profiles of non‐substituted PAHs (27 congeners), alkyl‐PAHs (15 congeners), and nitro‐PAHs (7 congeners) from the same EOM samples from these cities. We also compared the genotoxicity profiles using comet and micronucleus assays in human bronchial epithelial cells. The profiles of PAHs, as well as the cytotoxic and genotoxic potencies when expressed in EOM, were quite similar among the studied cities. It seems that despite the differences in meteorological conditions and pollution sources of the cities, removal, mixing, and different atmospheric transformation processes may be contributing to the similarity of the PAHs composition and genotoxicity profiles. More studies are required to verify if this would be a general rule applicable to other cities. Although these profiles were similar for all three cities, the EOM concentration in the atmospheres is markedly different. Thus, the population of Limeira (∼10‐fold more EOM/m3 than Stockholm and ∼6‐fold more than Kyoto) is exposed to higher concentrations of genotoxic pollutants, and Kyoto's population is 1.5‐fold more exposed than Stockholm's. Therefore, to reduce the risk of human exposure to TSP genotoxins, the volume of emissions needs to be reduced.

show abstract

“…In 2013, the International Agency for Research on Cancer (IARC) reported that outdoor pollution and particulate matter are carcinogenic to humans (Group 1) [ 6 ]. Mutagenic/carcinogenic substances, such as polycyclic aromatic hydrocarbons (PAHs), are formed by the incomplete combustion of organic matter such as fossil fuels [ 7 ] and these substances were mainly detected in fine particles [ 8 , 9 ]. Therefore, long-range transport of anthropogenic air pollutants including mutagens may occur in East Asia by the winter monsoon and the prevailing westerlies in winter and spring, respectively.…”

Section: Introductionmentioning

confidence: 99%

Long-range transport of mutagens and other air pollutants from mainland East Asia to western Japan

et al. 2015

Self Cite

View full text Add to dashboard Cite

IntroductionAsian dust events, transport of dust particles from arid and semi-arid areas in China and Mongolia to the east by prevailing westerlies, are often observed in Japan in spring. In recent decades, consumption of fossil fuels has markedly increased in mainland East Asia with rapid economic growth, and severe air pollution has occurred. A part of air pollutants including mutagens, such as polycyclic aromatic hydrocarbons (PAHs), generated in mainland East Asia are thought to be transported to Japan by the prevailing westerlies, like Asian dust, and winter monsoon. The objective of this study was to clarify the long-range transport of mutagens and other air pollutants in East Asia. Thus, we collected total suspended particles (TSP) at a rural town in western Japan, namely, Yurihama in Tottori Prefecture, for 1 year (June 2012–May 2013), and investigated their chemical constituents and mutagenicity.ResultsMany TSP collected from January to March showed high mutagenicity toward Salmonella typhimurium YG1024 with and without S9 mix, and high levels of lead (Pb) and sulfate ions (SO42−), which are indicators of transboundary air pollutions from mainland East Asia, were detected in those TSP. A large amount of iron, which is an indicator of sand, was found in highly mutagenic TSP collected in March, but not in TSP collected in January and February. High levels of PAHs were detected in highly mutagenic TSP collected from January to March. The ratios of the concentration of fluoranthene to those of fluoranthene and pyrene suggested that the main source of PAHs in TSP collected in winter and spring was coal and biomass combustion. Backward trajectories of air masses on days when high levels of mutagenicity were found indicated that these air masses had traveled from eastern or northern China to Yurihama.ConclusionsThese results suggest that high levels of mutagens were transported from mainland East Asia to western Japan, and this transportation accompanied Asian dust in March, but not in January and February.

show abstract

Development of an Analytical Method for Strong Mutagens/Carcinogens, 3,9-Dinitrofluoranthene and Dinitropyrene Isomers, in the Environment and Their Particle-Size Distribution in Airborne Particles

Cited by 5 publications

References 19 publications

Comparison of Air Pollution in Metropolises in China (Beijing) and Japan (Osaka and Nagoya) on the Basis of the Levels of Contaminants and Mutagenicity

Comparison of Air Pollution in Metropolises in China (Beijing) and Japan (Osaka and Nagoya) on the Basis of the Levels of Contaminants and Mutagenicity

Similar polycyclic aromatic hydrocarbon and genotoxicity profiles of atmospheric particulate matter from cities on three different continents

Long-range transport of mutagens and other air pollutants from mainland East Asia to western Japan

Contact Info

Product

Resources

About