Development of an Adjustable Prosthesis for the Treatment of Gastroesophageal Reflux Preliminary Results in a Porcine Model

Carugno, F; Donohue, John H.; Moreno, E; Byrne, John G.; Hodge, David O.; Ilstrup, Duane M.; Sarr, Michael G.

doi:10.1097/00002480-199805000-00005

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“…Especially in the survey of antireflux procedures this model has been frequently applied. It has been previously shown that the anatomy of the GE junction is quite similar to the situation in humans and that diagnostic and therapeutic procedures of that region can easily be performed [3,6,9,10,13,28] Meanwhile two studies applying pH monitoring have been published. Kadirkamanathan et al [21] established a method for long-term examination in six pigs using a pH-sensitive capsule that was fixed to the esophageal mucosa endoscopically.…”

Section: Discussionmentioning

confidence: 99%

Ambulatory long-term pH monitoring in pigs

et al. 2003

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Section: Discussionmentioning

confidence: 99%

Ambulatory long-term pH monitoring in pigs

et al. 2003

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Vertical banded gastroplasty versus adjustable gastric banding: prospective long-term follow-up study

Miller¹,

Pump²,

Hell³

2007

Surgery for Obesity and Related Diseases

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Vicente

Rocha

et al. 2001

Digestive Diseases and Sciences

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We describe the anatomy and function of the gastroesophageal barrier in the piglet. Male piglets underwent dissection (N = 6) and gastroesophageal muscle layer histometry (N = 6). Sedated, nonintubated animals (N = 13) underwent four-probe perfusion esophageal manometry and the pressure profiles were related to the muscular thickness in the four quadrants. Hiatal and gastroesophageal anatomy are similar to our own. The muscle is thicker at the point where the clasp (on the right side) and sling fibers (on the left) concentrate. The pressure profiles were axially and radially asymmetric in coincidence with the thickness variations of the corresponding muscle layers. Sphincteric pressure was recorded as a plateau, whereas diaphragmatic crural pressure appeared as phasic oscillations in synchrony with respiration. The sphincter relaxed upon deglutition. In conclusion, the gastroesophageal structure and physiology are so similar in men and piglets that piglets are excellent models for research in this area.

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Development of an Adjustable Prosthesis for the Treatment of Gastroesophageal Reflux Preliminary Results in a Porcine Model

Cited by 4 publications

References 0 publications

Ambulatory long-term pH monitoring in pigs

Ambulatory long-term pH monitoring in pigs

Vertical banded gastroplasty versus adjustable gastric banding: prospective long-term follow-up study

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