Development of alginate microspheres as nystatin carriers for oral mucosa drug delivery

Martín, María del Mar López; Calpena, Ana Cristina; Fernández, Francisco Arnalich; Mallandrich, Mireia; Gálvez, Patrícia; Clares, Beatriz

doi:10.1016/j.carbpol.2014.09.032

Cited by 73 publications

(37 citation statements)

References 38 publications

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“…The specific surface characteristics of nanocarriers can increase the contact between loaded drug and intestinal mucosa and enhance cellular uptake of formulation [3,12,13]. High local drug concentration is created in lesion, resulting in high mortality of cancer cell, which is beneficial to decrease the required dosage and frequency of administration, reduced toxicity and cost [14,15].…”

Section: Introductionmentioning

confidence: 99%

Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery

Feng

Kong

et al. 2015

Colloids and Surfaces B: Biointerfaces

110

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Section: Introductionmentioning

confidence: 99%

Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery

Feng

Kong

et al. 2015

Colloids and Surfaces B: Biointerfaces

110

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“…1 Limitations such as poor patient compliance (due to missing or altering dosages) and difficulty in attainment of steady state conditions (as a result of peakvalley plasma concentration fluctuations) have led to poor drug efficacy and toxicity as consequences of underdosing and overdosing of drugs respectively in patients. 2 Drug delivery systems have been designed to overcome these limitations and extend, delay and target drug release [3][4][5][6] . When properly designed, controlled drug delivery systems should be able to deliver drugs at a predetermined rate and manner, either locally or systemically, for a specific period of time after drug administration, which can eliminate excessive fluctuations of drug plasma concentrations.…”

Section: Introductionmentioning

confidence: 99%

Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

Ekanem

Nabavi

Vladisavljević

et al. 2015

ACS Appl. Mater. Interfaces

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Biodegradable poly(DL-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) microparticles with tunable size, shape, internal structure and surface morphology were produced by counter-current flow focusing in axisymmetric (3D) glass capillary devices. The dispersed phase was composed of 0.5-2 wt% polymer solution in a volatile 2 organic solvent (ethyl acetate or dichloromethane) and the continuous phase was 5 wt% aqueous poly(vinyl alcohol) solution. The droplets with a coefficient of variation in dripping regime below 2.5 % were evaporated to form polymeric particles with uniform sizes ranging between 4-30 µm. The particle microstructure and surface roughness were modified by adding nanofiller (montmorillonite nanoclay) or porogen (2-methylpentane) in the dispersed phase to form less porous polymer matrix or porous particles with golf-ball-like dimpled surface, respectively. The presence of 2-4 wt% nanoclay in the host polymer significantly reduced the release rate of paracetamol and prevented the early burst release, as a result of reduced polymer porosity and tortuous path for the diffusing drug molecules. Numerical modelling results using the volume of fluid-continuum surface force model agreed well with experimental behaviour and revealed trapping of nanoclay particles in the dispersed phase upstream of the orifice at low dispersed phase flow rates and for 4 wt% nanoclay content, due to vortex formation. Janus PLA/PCL (polycaprolactone) particles were produced by solvent evaporation-induced phase separation within organic phase droplets containing 3 % (v/v) PLA/PCL (30/70 or 70/30) mixture in dichloromethane. A strong preferential adsorption of Rhodamine 6G dye onto PLA was utilized to identify PLA portions of the Janus particles by Confocal Laser Scanning Microscopy (CLSM). Uniform hemispherical PCL particles were produced by dissolution of PLA domes with acetone.

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“…In fact, the term 'buccal', even if sometimes wrongly is used to indicate the mucosa of the total oral cavity, refers to the lining of the cheek and the upper and lower lips, which represent one-third of the total oral mucosa surface (Rossi et al, 2005). In this way, studies have also demonstrated a reservoir function of the buccal mucosa with drug retention, and a slow transfer into the systemic circulation providing optimal conditions for the local action of doxepin that otherwise could lead to undesirable central effects (Fernández Campos et al, 2012;Martín et al, 2015).…”

Section: Resultsmentioning

confidence: 97%

Transbuccal delivery of doxepin: Studies on permeation and histological investigation

Gimeno

Calpena

Sanz

et al. 2014

International Journal of Pharmaceutics

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Development of alginate microspheres as nystatin carriers for oral mucosa drug delivery

Cited by 73 publications

References 38 publications

Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery

Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery

Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

Transbuccal delivery of doxepin: Studies on permeation and histological investigation

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