Development of advanced antimicrobial and sterilized plasma polypropylene grafted muga (antheraea assama) silk as suture biomaterial

Abstract

Surface modification of silk fibroin (SF) materials using environmentally friendly and non-hazardous process to tailor them for specific application as biomaterials has drawn a great deal of interest in the field of biomedical research. To further explore this area of research, in this report, polypropylene (PP) grafted muga (Antheraea assama) SF (PP-AASF) suture is developed using plasma treatment and plasma graft polymerization process. For this purpose, AASF is first sterilized in argon (Ar) plasma treatment followed by grafting PP onto its surface. AASF is a non-mulberry variety having superior qualities to mulberry SF and is still unexplored in the context of suture biomaterial. AASF, Ar plasma treated AASF (AASFAr) and PP-AASF are subjected to various characterization techniques for better comparison and the results are attempted to correlate with their observed properties. Excellent mechanical strength, hydrophobicity, antibacterial behavior, and remarkable wound healing activity of PP-AASF over AASF and AASFAr make it a promising candidate for application as sterilized suture biomaterial.

Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering Applications

“…Bioceramics have also been used in combination with different biomacromolecules, such as collagen or chitosan, to prepare composite scaffolds to be used as bone implants [ 137 , 138 , 139 , 140 ]. Amongst them, silk fibroin (SF) appears as an interesting material for BTE due to its excellent mechanical and functional properties, low immunogenicity and good biocompatibility [ 137 , 141 ]. Thus, SF has been employed in combination with HA to render SF/HA composite scaffolds with excellent biocompatibility, osteoconductivity, and osteoinductivity [ 142 , 143 ].…”

Antimicrobials tethering on suture surface through a hydrogel: a novel strategy to combat postoperative wound infections

“…Silk broins are classied into two main types namely mulberry (Bombyx mori) and non-mulberry varieties including muga (Antheraea assama), eri (Philosamia ricini), tasar (Antheraea mylitta). 9 Bombyx mori silk broin (BMSF) has been characterised and commercially available biomaterial worldwide for centuries. 10 Among the non-mulberry silk P. ricini and A. assama has been widely studied in the eld of biomaterial.…”

Chitosan‐finished Antheraea mylitta silk fibroin nonwoven composite films for wound dressing

“…As shown later in Figure , we observed that the position of peaks present in the diffraction curves of the TFF and CMTFF samples remained unchanged. Gogoi et al . previously reported that the diffraction curves at a 2θ of 20.2 ° were characteristic of the highly ordered antiparallel β‐sheet crystalline structure of the poly(glycine–alanine) chain.…”