Development of a versatile microencapsulation technique for aqueous phases using inverse emulsion

Zhang, He; Chen, Kaipeng; Yang, Jinglei

doi:10.1016/j.colsurfa.2021.127865

Cited by 15 publications

(9 citation statements)

References 33 publications

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“…In the encapsulation and release of pharmaceuticals the process of microparticle production is a determining factor 19 – 23 . Furthermore, many parameters such as the type of polymer, polymer molecular weight, copolymer composition, nature of excipients used in the microparticle formulation (e.g., for drug stability), porosity and microparticle size can all have a significant impact on distribution rates 24 – 30 .…”

Section: Introductionmentioning

confidence: 99%

Impact of dispersion time interval and particle size on release profiles of propranolol HCl and carbamazepines from microparticle blends system

Muhaimin

Chaerunisaa

Bodmeier

2022

Sci Rep

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The objective of this study was to investigate the effect of dispersion time interval (DTI) on physicochemical properties of drug following the incorporation of propranolol HCl (Pro) and carbamazepine (CBZ) within ethyl cellulose (EC) microparticle blends using solvent evaporation method. The first Pro emulsion and second CBZ oil phase were dispersed in an external aqueous phase, with DTI of 0 and 60 min. The morphology of microparticle blends were characterized by SEM. The particle size mean of the emulsion droplets/hardened microparticles were monitored by FBRM. Encapsulation efficiency (EE) and in vitro drug release were also investigated. The resulting microparticle blends were spherical and formed two populations. The particle size mean of microparticle blends ranged from 113.27 µm to 122.42 µm. The EE was 77.28% to 78.64% for Pro and 96.48% to 98.64% for CBZ. FBRM studies showed that the size of microparticle blend prepared as W/O/W (Pro) and O/W (CBZ) system with DTI of 60 min and stirring time 4 h were larger than those prepared with DTI of 0 min. In vitro drug release studies after 28 days that revealed the CBZ release (58.72%) was faster than Pro release (43.16%). Investigation on surface morphology by SEM showed that the second drug CBZ which added as the oil phase in the W/O/W emulsion system had blocked the pores on the surface Pro microparticles prepared from the first primary emulsion, therefore affecting the drug release. This blocking effects of second drug (CBZ) on first emulsion microparticles (Pro) depended on the DTI. This phenomenon is only applicable if the first primary emulsion is W/O/W system.

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Section: Introductionmentioning

confidence: 99%

Impact of dispersion time interval and particle size on release profiles of propranolol HCl and carbamazepines from microparticle blends system

Muhaimin

Chaerunisaa

Bodmeier

2022

Sci Rep

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“…32,33 Especially, Arlacel-P135 (PEG-30 dipolyhydroxystearate), 34 as an A-B-A triblock copolymer surfactant, greatly enhances the strength of the interfacial film and facilitates the stability of the emulsion by means of its two bulky lipophilic groups, forming a special nonrotating three-dimensional space at the interface of emulsion. 35,36 In the present work, the effects of the oil−water interface film on the breakup characteristics of W/O emulsion droplets are studied. For comparison, emulsions are prepared by nonionic surfactants and the polymer surfactant Arlacel-P135.…”

Section: Introductionmentioning

confidence: 99%

“…However, emulsion films obtain higher stability when in the presence of another polymer surfactant Pluronics (A-B-A triblock copolymers) . Similar to the asphaltene molecules, polymer surfactants can form a stable interfacial film with a microscopic three-dimensional network structure at the oil–water interface by entanglement and hydrophobic association of the long molecular chains. , Especially, Arlacel-P135 (PEG-30 dipolyhydroxystearate), as an A-B-A triblock copolymer surfactant, greatly enhances the strength of the interfacial film and facilitates the stability of the emulsion by means of its two bulky lipophilic groups, forming a special nonrotating three-dimensional space at the interface of emulsion. , …”

Section: Introductionmentioning

confidence: 99%

Breakup Characteristics of Water-in-Oil Emulsion Droplets Influenced by a Rigid Interfacial Film in the Presence of a Polymer Surfactant

Gao

et al. 2022

Energy Fuels

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The emulsified feedstock technique derived from micro-explosion has been applied to improve the feedstock atomization of heavy oil during the catalytic cracking process. The strength of an interfacial film, which is vital for the stability of emulsion, can be enhanced by some polymer surfactants. In this study, n-hexadecane was chosen as the model oil. The effect of oil–water interfacial film properties on the high-temperature breakup of emulsified droplets was investigated, especially the interfacial film strength of water-in-oil (W/O) emulsion in the presence of a commonly used non-ionic surfactant and/or polymer surfactant (Arlacel-P135). The mean diameter of dispersed water and interfacial tension and interfacial film strength of emulsions were measured. Afterward, two breakup modes of emulsified droplets were revealed by the single droplet heating test, which are “micro-explosion” and “breakup after bubble expansion”. The emulsified droplet stabilized by Arlacel-P135 is more prone to “breakup after bubble expansion” for the rigid oil–water interfacial film hindering the coalescence of dispersed water. The stability and oil–water interfacial strength of emulsions stabilized by mixed surfactants consisting of Span80, Tween80, and Arlacel-P135 were enhanced with the increase in Arlacel-P135 dosage. Moreover, the addition of Arlacel-P135 (0.2–0.5 wt %) significantly reduced the average breakup delay time (τ) of W/O droplets, since the bubble nucleation was favored by the interfacial film structure formed by polymer surfactant.

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“…Microencapsulation is an important technique used for drug delivery systems obtaining [16][17][18][19]. However, obtaining microcapsules based on interpolymeric complexes is complicated due to the formation of matrices of large size and uncontrolled dispersion.…”

Section: Introductionmentioning

confidence: 99%

Отримання Мікрокапсул На Основі Комлексів Хітозану Та Карбоксиметилцелюлози Мембранною Емульсифікацією

Konovalova

Колесник²,

Побігай

et al. 2022

J. of Chem. and Tech.

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У роботі термо- та рН-чутливі мікрокапсули отримані на основі поліелектролітного комплексу хітозан-карбоксиметилцелюлоза методом мембранної емульсифікації. Мікрокапсули розміром 200-250 нм отримані з використанням трекової ПЕТФ мембрани з розміром пор 0,1 мкм. Стабільність мікрокапсул, їх розподіл за розміром, дзета-потенціал поверхні та вплив температури та рН на розмір частинок досліджено методом динамічного світлорозсіювання. Утворення комплексу підтверджено методом ІЧ спектроскопії та досліджено структуру комплексів при різних співвідношеннях полімерів методом візкозиметрії. Досліджено кінетику вивільнення папаверин гідрохлориду із мікрокапсул на основі комплексів хітозан:КМЦ при співвідношеннях 1:1 та 3:2. Даний метод є простою технікою для отримання мікрокапсул з інтерполімерних комплексів шляхом почергового введення розчинів полімерів в дисперсійне середовище, що дає можливість отримання монодисперсних суспензій визначеного розміру та ефективної іммобілізації широкого спектру фармацевтичних інгредієнтів.

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Development of a versatile microencapsulation technique for aqueous phases using inverse emulsion

Cited by 15 publications

References 33 publications

Impact of dispersion time interval and particle size on release profiles of propranolol HCl and carbamazepines from microparticle blends system

Impact of dispersion time interval and particle size on release profiles of propranolol HCl and carbamazepines from microparticle blends system

Breakup Characteristics of Water-in-Oil Emulsion Droplets Influenced by a Rigid Interfacial Film in the Presence of a Polymer Surfactant

Отримання Мікрокапсул На Основі Комлексів Хітозану Та Карбоксиметилцелюлози Мембранною Емульсифікацією

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