Development of a UPLC-ESI-MS/MS method to measure urinary metabolites of selected VOCs: Benzene, cyanide, furfural, furfuryl alcohol, 5-hydroxymethylfurfural, and N-methyl-2-pyrrolidone

Bhandari, Deepak; McCarthy, Declan P.; Biren, Chloe; Movassaghi, Cameron S.; Blount, Benjamin C.; Jesús, Víctor R. De

doi:10.1016/j.jchromb.2019.121746

Cited by 17 publications

(15 citation statements)

References 29 publications

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“…(7,25,26) Based on toxicology, exposure experiments and eld monitoring were widely conducted to assess the health risk of speci c population groups (27)(28)(29)(30)(31). Ambient VOCs concentration from long-term monitor system was also used as inhalation exposure level in health risk assessment (32)(33)(34)(35)(36), and a subsequent effort to explore biomarkers highlighted that metabolic pathways (or mechanism of activation) of chemical species in the body were generally not isolated (37)(38)(39)(40). Additionally, interaction mechanism and pro le were probed to indicate joint toxic action of the chemicals in mixture (41,42), especially the mixtures of concern such as BTEX (benzene, toluene, ethylbenzene, xylenes) (43).…”

Section: Main Textmentioning

confidence: 99%

Tracking health threat from gaseous organic mixture in industry

Wang,

Zhang,

Zhao

et al. 2023

Preprint

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Industrial production emits a multitude of pollutants, among which volatile organic compounds (VOCs) almost exists in every industry. Serving as central factor in atmospheric chemistry, VOCs has been strictly controlled worldwide. However, a gap between VOCs regulation and health effect has increased owing to the complexity of characterizing deleterious species and understanding their hazards. We learned the exposure profiles of occupational workers in 24 VOCs-related industries, identified the aggregate risk of individual species, and assessed the cumulative risk for affected organs /tissues. Results showed that toxic species in exposed VOCs mixture significantly increased the burden on respiratory, reproductive, hepatic, urinary, immune, and developmental system. We further developed an accompanying understanding of how ongoing control measures reduced health threats and proposed long and short-term strategy to improve health. The results highlight the importance of considering health and atmospheric chemistry equally in determining VOCs limits, and thus harmonize environment and human simultaneously.

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Section: Main Textmentioning

confidence: 99%

Tracking health threat from gaseous organic mixture in industry

Wang,

Zhang,

Zhao

et al. 2023

Preprint

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“…Various analytical approaches have been introduced to measure tt-MA in urine samples, including high-performance liquid chromatography (HPLC), gas chromatography (GC), ultraviolet and visible spectrophotometry (UV-vis) and mass spectrometry (MS). Bhandari et al [7] developed an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for simultaneously measuring 8 biomarkers of volatile organic compound (VOC) exposure, including tt-MA. Ruppert et al [14] developed a sensitive and specific method for the determination of tt-MA in urine analyzed by gas chromatography-mass spectrometry (GC-MS).…”

Section: Different Analytical Techniques For the Determination Of Tt-ma In Urine Samplesmentioning

confidence: 99%

“…Long-term occupational and environmental exposure to benzene may cause bone marrow damage, leukemia, aplastic anemia and so on [6]. Trans, trans-muconic acid (tt-MA) and S-phenylmercapturic acid (S-PMA) are the most commonly used urinary biomarkers associated with benzene exposure in humans to be detected from urine or blood [7][8][9]. The American Conference of Governmental Industrial Hygienists (ACGIH) has recommended tt-MA as a biological exposure index (BEI) which is suitable urinary biomarker of benzene at high concentrations (above 1 ppm) [1,[10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Different Analytical Techniques, Pretreatment Methods and Adsorbent Materials for the Determination of Trans, Trans-Muconic Acid in Urine Samples

2020

2020 2nd International Symposium on the Frontiers of Biotechnology and Bioengineering (FBB 2020)

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“…At present, new strategies are quickly appearing for CN − , HQ, and AA detection including chromatography, 17 capillary electrophoresis, 18 colorimetry, 19 and fluorescence probe. In these methods, the fluorescence probe has the advantages of simple and rapid operation, possibility for rapid and real-time detection, and high sensitivity.…”

Section: ■ Introductionmentioning

confidence: 99%

Coumarin-Modified Graphene Quantum Dots as a Sensing Platform for Multicomponent Detection and Its Applications in Fruits and Living Cells

Yu¹,

Ma²,

Wu³

et al. 2020

ACS Omega

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In this work, coumarin derivatives (C) are used to enhance the fluorescence of graphene quantum dots (GQDs) by covalently linking the carboxyl groups on the edge of the GQD sheet. The as-synthesized coumarin-modified graphene quantum dots (C-GQDs) have a uniform particle size with an average diameter of 3.6 nm. Simultaneously, the C-GQDs have strong fluorescence emission, excellent photostability, and high fluorescence quantum yield. C-GQDs and CN– can form a C-GQDs+CN– system due to deprotonation and/or intermolecular interactions. The introduced hydroquinone (HQ) is oxidized to benzoquinone (BQ), and the interaction between BQ and the C-GQDs+CN– system could lead to fluorescence enhancement of C-GQDs. Meanwhile, the redox reaction between BQ and ascorbic acid (AA) can be used for quantitative detection of AA with CN– and HQ being used as substrates. Based on the above mechanism, C-GQDs are developed as a multicomponent detection and sensing platform, and the detection limits for CN–, HQ, and AA were 4.7, 2.2, and 2.2 nM, respectively. More importantly, satisfactory results were obtained when the platform was used to detect CN–, HQ, and AA in living cells and fresh fruits.

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Development of a UPLC-ESI-MS/MS method to measure urinary metabolites of selected VOCs: Benzene, cyanide, furfural, furfuryl alcohol, 5-hydroxymethylfurfural, and N-methyl-2-pyrrolidone

Cited by 17 publications

References 29 publications

Tracking health threat from gaseous organic mixture in industry

Tracking health threat from gaseous organic mixture in industry

Different Analytical Techniques, Pretreatment Methods and Adsorbent Materials for the Determination of Trans, Trans-Muconic Acid in Urine Samples

Coumarin-Modified Graphene Quantum Dots as a Sensing Platform for Multicomponent Detection and Its Applications in Fruits and Living Cells

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