Different Analytical Techniques, Pretreatment Methods and Adsorbent Materials for the Determination of Trans, Trans-Muconic Acid in Urine Samples

Abstract

Benzene is a human carcinogen and its metabolite, Trans, trans-muconic acid (tt-MA) has been introduced by some environmental and occupational health regulatory associations as a biological index for the assessment of benzene exposure. This paper summaried and compared different analytical techniques, pretreatment methods and adsorbent materials for the determination of tt-MA in urine samples.