Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology

Pentek, Tyler; Newenhouse, Eric; O'Brien, Brennin; Chauhan, Abhay Singh

doi:10.3390/molecules22010137

Cited by 80 publications

(47 citation statements)

References 12 publications

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“…Formulations of resveratrol have also been used for several other clinical conditions . For example, micronized resveratrol is reported to reduce blood pressure in hypertensive patients when coadministered with standard antihypertensive medication.…”

Section: Completed Clinical Trialsmentioning

confidence: 99%

“…188 Formulations of resveratrol have also been used for several other clinical conditions. [189][190][191][192] For example, micronized resveratrol is reported to reduce blood pressure in hypertensive patients when coadministered with standard antihypertensive medication. Moreover, a significant reduction in ALT and γ-GT levels, support the antiinflammatory and hepatoprotective effects of resveratrol.…”

Section: Other Diseasesmentioning

confidence: 99%

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Health benefits of resveratrol: Evidence from clinical studies

Singh

Verma

et al. 2019

Medicinal Research Reviews

354

238

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Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in over 244 clinical trials, with an additional 27 clinical trials currently ongoing. Resveretrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis. The polyphenol is reported to be safe at doses up to 5 g/d, when used either alone or as a combination therapy. The molecular basis for the pleiotropic activities of resveratrol are based on its ability to modulate multiple cell signaling molecules such as cytokines, caspases, matrix metalloproteinases, Wnt, nuclear factor‐κB, Notch, 5′‐AMP‐activated protein kinase, intercellular adhesion molecule, vascular cell adhesion molecule, sirtuin type 1, peroxisome proliferator‐activated receptor‐γ coactivator 1α, insulin‐like growth factor 1, insulin‐like growth factor‐binding protein 3, Ras association domain family 1α, pAkt, vascular endothelial growth factor, cyclooxygenase 2, nuclear factor erythroid 2 like 2, and Kelch‐like ECH–associated protein 1. Although the clinical utility of resveratrol is well documented, the rapid metabolism and poor bioavailability have limited its therapeutic use. In this regard, the recently produced micronized resveratrol formulation called SRT501, shows promise. This review discusses the currently available clinical data on resveratrol in the prevention, management, and treatment of various diseases and disorders. Based on the current evidence, the potential utility of this molecule in the clinic is discussed.

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Section: Completed Clinical Trialsmentioning

confidence: 99%

Section: Other Diseasesmentioning

confidence: 99%

Health benefits of resveratrol: Evidence from clinical studies

Singh

Verma

et al. 2019

Medicinal Research Reviews

354

238

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“…The improvement of bioavailability and delivery of resveratrol in human was studied by Pentek et al; they developed a topical resveratrol formulation for commercial applications using dendrimer nanotechnology [ 1 ].…”

mentioning

confidence: 99%

Special Issue: Improvements for Resveratrol Efficacy

2017

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“…Resveratrol is a stilbene compound known for its anti-oxidant/anti-ageing properties that suffers from poor water solubility [172] developed a G4, PAMAM dendrimer formulation for transdermal applications with improved water solubility, stability and skin penetration. Resveratrol is a stilbene compound known for its anti-oxidant/anti-ageing properties that suffers from poor water solubility [172] developed a G4, PAMAM dendrimer formulation for transdermal applications with improved water solubility, stability and skin penetration. Resveratrol PAMAM hybrid Improved solubility [172] Resveratrol is a stilbene compound known for its anti-oxidant/anti-ageing properties that suffers from poor water solubility [172] developed a G4, PAMAM dendrimer formulation for transdermal applications with improved water solubility, stability and skin penetration.…”

Section: Anti-oxidant Compoundsmentioning

confidence: 99%

“…Resveratrol is a stilbene compound known for its anti-oxidant/anti-ageing properties that suffers from poor water solubility [172] developed a G4, PAMAM dendrimer formulation for transdermal applications with improved water solubility, stability and skin penetration. Resveratrol PAMAM hybrid Improved solubility [172] Resveratrol is a stilbene compound known for its anti-oxidant/anti-ageing properties that suffers from poor water solubility [172] developed a G4, PAMAM dendrimer formulation for transdermal applications with improved water solubility, stability and skin penetration. Gallic Acid PAMAM conjugation Improved bioavailability [173] 4.1.6.…”

Section: Anti-oxidant Compoundsmentioning

confidence: 99%

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

Tomalia

Nixon²,

Hedstrand³

2020

Biomolecules

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This article reviews progress over the past three decades related to the role of dendrimer-based, branch cell symmetry in the development of advanced drug delivery systems, aqueous based compatibilizers/solubilizers/excipients and nano-metal cluster catalysts. Historically, it begins with early unreported work by the Tomalia Group (i.e., The Dow Chemical Co.) revealing that all known dendrimer family types may be divided into two major symmetry categories; namely: Category I: symmetrical branch cell dendrimers (e.g., Tomalia, Vögtle, Newkome-type dendrimers) possessing interior hollowness/porosity and Category II: asymmetrical branch cell dendrimers (e.g., Denkewalter-type) possessing no interior void space. These two branch cell symmetry features were shown to be pivotal in directing internal packing modes; thereby, differentiating key dendrimer properties such as densities, refractive indices and interior porosities. Furthermore, this discovery provided an explanation for unimolecular micelle encapsulation (UME) behavior observed exclusively for Category I, but not for Category II. This account surveys early experiments confirming the inextricable influence of dendrimer branch cell symmetry on interior packing properties, first examples of Category (I) based UME behavior, nuclear magnetic resonance (NMR) protocols for systematic encapsulation characterization, application of these principles to the solubilization of active approved drugs, engineering dendrimer critical nanoscale design parameters (CNDPs) for optimized properties and concluding with high optimism for the anticipated role of dendrimer-based solubilization principles in emerging new life science, drug delivery and nanomedical applications.

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Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology

Cited by 80 publications

References 12 publications

Health benefits of resveratrol: Evidence from clinical studies

Health benefits of resveratrol: Evidence from clinical studies

Special Issue: Improvements for Resveratrol Efficacy

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

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