Development of a thin-layer chromatographic method for the enantioresolution of sotalol using levofloxacin as chiral selector

Vashistha, Vinod Kumar; Kumar, Anuj

doi:10.1007/s00764-020-00068-3

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…Extraction of API was performed by employing the method established in the literature 16–18 . Briefly, 10 sivextro tablets (each containing 200 mg of TED) were ground well in a mortar.…”

Section: Methodsmentioning

confidence: 99%

Enantioseparation of linezolid and tedizolid using validated high‐performance liquid chromatographic method

et al. 2022

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This paper reports the separation of two chiral antibacterial agents namely, linezolid and tedizolid using a validated high‐performance liquid chromatographic method. In the current work, glycopeptide‐based chiral column, CHIROBIOTIC® V2 (5‐μm particle size, L × I.D. 25 cm × 4.6 mm) was employed with a mobile phase containing methanol and 0.15% aq. trifluoracetic acid (75:25%, v/v) in isocratic elution approach at flow rate of 1 ml min−1. The separation condition was customized (in terms of resolution values and retention times) was carried out by changing the content of the mobile phase, column temperature, flow rate, and so on. Results showed that the chromatographic separation was achieved within 15 min and average resolution values were 4.6 and 4.8 for tedizolid and linezolid, respectively. The detection limit values were 14.85 and 14.16 ng ml−1, respectively, for tedizolid enantiomers. Further, validation of separation parameters was performed by considering the international conference on harmonization guidelines, and ultimately, the mechanism of chiral recognition was also established.

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“…Extraction of API was performed by employing the method established in the literature 16–18 . Briefly, 10 sivextro tablets (each containing 200 mg of TED) were ground well in a mortar.…”

Section: Methodsmentioning

confidence: 99%

Enantioseparation of linezolid and tedizolid using validated high‐performance liquid chromatographic method

et al. 2022

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“…The chirality of pharmaceutically important compounds was widely researched with the development of stereoselective chromatographic methods by our research group during the last few years. [47][48][49][50][51][52][53][54][55] Chiral compounds create difficulties in enantiospecific preparation, characterization, and analysis. 56 When such substances are deliberately placed in the ecosystem, even more, complex issues are generated in detection, surveillance, and prediction of their destiny and risks.…”

Section: Detection and Remediation Of Chiral Pharmaceuticalsmentioning

confidence: 99%

“…To optimize successful separation, the role of chiral selector concentration, pH, and temperature were examined. 55 In a review by Batra et al, the possibilities made available for quantifying stereoisomers (RS)-ATL were described. The LC methods were considered for (RS)-ATL enantiomeric separation through both directly and indirectly through several CSPs for practical applications using chiral derivatives and ligand exchange and impregnation strategies.…”

Section: Detection and Remediation Of Chiral Pharmaceuticalsmentioning

confidence: 99%

“…The major analytical techniques for the detection and quantification of chiral pharmaceuticals include various chromatographic and capillary electrophoresis techniques. The chirality of pharmaceutically important compounds was widely researched with the development of stereoselective chromatographic methods by our research group during the last few years 47–55 . Chiral compounds create difficulties in enantiospecific preparation, characterization, and analysis 56 .…”

Section: Stereochemical Aspects Of Chiral Pharmaceuticalsmentioning

confidence: 99%

“…In indirect strategy, the diastereomers were synthesized with ( S )‐naproxen, which were subsequently resolved by achiral plates with no chiral selector. To optimize successful separation, the role of chiral selector concentration, pH, and temperature were examined 55 . In a review by Batra et al, the possibilities made available for quantifying stereoisomers ( RS )‐ATL were described.…”

Section: Stereochemical Aspects Of Chiral Pharmaceuticalsmentioning

confidence: 99%

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Detection and remediation of chiral pharmaceuticals from wastewater: A review

Vashistha

2022

Chirality

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Chiral organic pollutants including pharmaceuticals, pesticides, herbicides, flame retardants, and polycyclic musk cause significant risks to both the environment and human health. Chiral pharmaceuticals (CPs) are among the significant class of pseudo‐persistent substances that have been observed in the concentration level from nanomolar to micromolar quantities and cause bad impacts on nontargeted species and direct or indirect human health issues due to water and foodborne contamination. The CPs may contain one or more chiral centers in their structural framework and thus enantiomers of CPs often possess different distribution, fate, bioaccumulation potential, and toxicity. The enantioselective chromatographic techniques have been extensively applied to detect drug enantiomers during the last few years. Bioremediation techniques offer unique characteristics above conventional remediation procedures as these could be cost‐effective and accomplish total organic pollutant decomposition without causing collateral damage to the site material or native flora and fauna. This review describes the impacts of chiral pharmaceuticals on the environment; detection technologies (particularly liquid chromatography), and important remedial measures for safer disposal of such pollutants.

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Chiral Analysis of Pharmaceuticals Using NMR Spectroscopy: A Review

Vashistha

2022

Asian J Org Chem

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Chirality recognition of pharmaceutical products plays a significant part in asymmetric synthesis, stereoselective catalysis, supramolecular chemistry, and the development of new drug substances. NMR spectroscopy is a potential technique utilized not only for the determination of chemical structure but also for chirality analysis. Three main approaches are developed for the assessment of the chirality of organic compounds through NMR spectroscopy that depends on the use of chiral discriminating agents such as chiral solvating agents, and chiral derivatizing agents. This article highlights the recent advances in chiral recognition of pharmaceutically important compounds using NMR spectroscopic methods.

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Development of a thin-layer chromatographic method for the enantioresolution of sotalol using levofloxacin as chiral selector

Cited by 9 publications

References 12 publications

Enantioseparation of linezolid and tedizolid using validated high‐performance liquid chromatographic method

Enantioseparation of linezolid and tedizolid using validated high‐performance liquid chromatographic method

Detection and remediation of chiral pharmaceuticals from wastewater: A review

Chiral Analysis of Pharmaceuticals Using NMR Spectroscopy: A Review

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