Development of a Sustained-release System for Nitric Oxide Delivery using Alginate/Chitosan Nanoparticles

Marcato, Priscyla D.; Adami, Leonardo F.; Barbosa, Raquel de Melo; Melo, Patrícia S.; Ferreira, Iasmin R.; Paula, Larissa de; Seabra, Amedea B.

doi:10.2174/157341313805117848

Cited by 9 publications

(12 citation statements)

References 42 publications

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“…Alginate NPs are excellent for encapsulating various drugs. Methylene blue, fluorescein sodium salt, nifedipine, gatifloxacin, rhodamine 6G, EGFR phosphorothioated 21-mer antisense 50, turmeric oil, epidermal growth factor, Bupivacaine, vitamin D 3 , 5-aminolevulinic acid, tuftsin, candida rugosa lipase, ibuprofen, ivermectin, enoxaparin, nitric oxide, benzoyl peroxide, and quinapyramine have all been encapsulated in alginate NPs for drug delivery [ 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 ] ( Table 4 ).…”

Section: Alginatementioning

confidence: 99%

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

et al. 2016

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Abstract:In recent years, there have been major advances and increasing amounts of research on the utilization of natural polymeric materials as drug delivery vehicles due to their biocompatibility and biodegradability. Seaweed polysaccharides are abundant resources and have been extensively studied for several biological, biomedical, and functional food applications. The exploration of seaweed polysaccharides for drug delivery applications is still in its infancy. Alginate, carrageenan, fucoidan, ulvan, and laminarin are polysaccharides commonly isolated from seaweed. These natural polymers can be converted into nanoparticles (NPs) by different types of methods, such as ionic gelation, emulsion, and polyelectrolyte complexing. Ionic gelation and polyelectrolyte complexing are commonly employed by adding cationic molecules to these anionic polymers to produce NPs of a desired shape, size, and charge. In the present review, we have discussed the preparation of seaweed polysaccharide-based NPs using different types of methods as well as their usage as carriers for the delivery of various therapeutic molecules (e.g., proteins, peptides, anti-cancer drugs, and antibiotics). Seaweed polysaccharide-based NPs exhibit suitable particle size, high drug encapsulation, and sustained drug release with high biocompatibility, thereby demonstrating their high potential for safe and efficient drug delivery.

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Section: Alginatementioning

confidence: 99%

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

et al. 2016

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“…An important observation in this system was that cytotoxicity for fibroblast V79 cells was not observed. These results showed the great potential of NO donor in plants Marcato et al 2013).…”

Section: Chitosan Nanoparticlesmentioning

confidence: 53%

“…Due to its great potential, nanoscience ( Ferreira et al 2013) were defined as "the study of phenomena and manipulation of materials at atomic, molecular and macromolecular scales, where properties differ significantly from those at a larger scale" and "the design, characterisation, production and application of structures, devices and systems by controlling shape and size at nanometer scale," respectively. According to Duncan (2011), the nanotechnology term involves the synthesis or preparation, characterization, and material manipulations (including structures and devices) in this dimension scale.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnologies in Food and Agriculture

Rai¹,

Ribeiro²,

Mattoso³

et al. 2015

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“…Microparticles of SNA with chitosan can also be prepared (Marcato et al, 2013). In addition, a polyelectrolyte complex of alginate with chitosan and Eudragit Õ L100-55 can also be prepared (Calija et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Synthesis of S-nitrosoglutathione-alginate for prolonged delivery of nitric oxide in intestines

et al. 2015

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S-nitrosothiols are a class of NO-donors currently under investigation for the treatment of various diseases. In this study, we developed a novel NO-donor (S-nitrosoglutathione-alginate, SNA) by cross-linking alginate with S-nitrosothiols, which can deliver NO in a sustained manner. This compound can be further evaluated for oral delivery to treat Crohn's disease. This new compound was prepared using a two-step procedure involving (I) linkage of reduced glutathione to alginate and (II) post-nitrosation with sodium nitrite (NaNO 2 ). The amount of linked thiol moieties for the possible nitrosation was calculated using Ellman's method, and the amount of NO abducted on the polymer was calculated using the Griess-Saville method. An ex vivo model (i.e. Ussing chamber) was used to investigate the permeation of this new NO-donor across the rat intestinal barrier. We obtained polymers with different numbers of abducted NOs (174 ± 21 mmol/g for SNA F1 and 468 ± 23 mmol/g for SNA F2) depending on the procedure used for nitrosation. In the ex vivo studies in the Ussing chamber, SNA F2 exhibited a sustained release for at least 10 h. The effect of pH on the stability of the new compound was also investigated, and the new compound was more stable at a mildly basic pH of 8.4 where 73% remained after 1 week. However, only 50% remained after 1 week at an acidic pH of 1.2. In the cytotoxicity studies (Caco2), this compound was nontoxic at concentrations of less than 200 mM.

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Development of a Sustained-release System for Nitric Oxide Delivery using Alginate/Chitosan Nanoparticles

Cited by 9 publications

References 42 publications

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

Nanotechnologies in Food and Agriculture

Synthesis of S-nitrosoglutathione-alginate for prolonged delivery of nitric oxide in intestines

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