Development of a silk fibroin-based multitask aerosolized nanopowder formula for efficient wound healing

Karaly, Ali H.; Sarhan, Wessam A.; El‐Sherbiny, Ibrahim M.

doi:10.1016/j.ijbiomac.2021.03.178

Cited by 16 publications

(15 citation statements)

References 46 publications

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“…Topical delivery of SF nanoparticles conjugated to therapeutic agents can effectively improve wound healing. Aerosolized SF nanoparticles were used to topically deliver Avicennia marina extract and neomycin into full-thickness rat wounds to successfully enhance healing [ 103 ]. Avicennia marina is a wooded plant, the extract of which has been found to have anti-inflammatory, antioxidant, and antimicrobial effects [ 104 ].…”

Section: Sf Nanoparticlesmentioning

confidence: 99%

“…Avicennia marina is a wooded plant, the extract of which has been found to have anti-inflammatory, antioxidant, and antimicrobial effects [ 104 ]. The extract has also been shown to stimulate the proliferation of fibroblasts and induce epithelization [ 103 ]. Neomycin is a common antibiotic used to prevent infection in a variety of tissues, including cutaneous wounds [ 105 ].…”

Section: Sf Nanoparticlesmentioning

confidence: 99%

“…The initial release could be beneficial for immediately killing any bacteria in the wound bed and stimulating the proliferation of fibroblasts, while the subsequent prolonged release could continue to promote a healthy wound bed throughout the healing process. Wounds treated with SF-loaded nanoparticles healed within 15 days, while negative control wounds remained open in the same timeframe [ 103 ]. The success of topical SF nanoparticles as a drug delivery mechanism suggests that the nanoparticles could be used dynamically with various drug combinations to treat a number of common wound ailments.…”

Section: Sf Nanoparticlesmentioning

confidence: 99%

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Silk Fibroin-Based Therapeutics for Impaired Wound Healing

et al. 2022

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Impaired wound healing can lead to local hypoxia or tissue necrosis and ultimately result in amputation or even death. Various factors can influence the wound healing environment, including bacterial or fungal infections, different disease states, desiccation, edema, and even systemic viral infections such as COVID-19. Silk fibroin, the fibrous structural-protein component in silk, has emerged as a promising treatment for these impaired processes by promoting functional tissue regeneration. Silk fibroin’s dynamic properties allow for customizable nanoarchitectures, which can be tailored for effectively treating several wound healing impairments. Different forms of silk fibroin include nanoparticles, biosensors, tissue scaffolds, wound dressings, and novel drug-delivery systems. Silk fibroin can be combined with other biomaterials, such as chitosan or microRNA-bound cerium oxide nanoparticles (CNP), to have a synergistic effect on improving impaired wound healing. This review focuses on the different applications of silk-fibroin-based nanotechnology in improving the wound healing process; here we discuss silk fibroin as a tissue scaffold, topical solution, biosensor, and nanoparticle.

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Section: Sf Nanoparticlesmentioning

confidence: 99%

Section: Sf Nanoparticlesmentioning

confidence: 99%

Section: Sf Nanoparticlesmentioning

confidence: 99%

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Silk Fibroin-Based Therapeutics for Impaired Wound Healing

et al. 2022

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“…Treating with fibroin biomaterials dressing for 10 days decreased the wound size to approximately 30%, further decreased to about 11% after 15 days, whereas these measures in the control group with no treatment were 52% and 49%, respectively [ 78 ]. Concerning skin health, a wide variety of new dosage forms for silk and its constituents have been brought into play, including nano-porous films [ 79 ], insulin-encapsulated silk fibroin microparticles dressing [ 80 ], lyophilized silk fibroin dressing [ 81 ], aerosolized nanopowder [ 82 ].…”

Section: Pharmacological Effectsmentioning

confidence: 99%

Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities

Biganeh

Kabiri

Zeynalpourfattahi

et al. 2022

Heliyon

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“…7b). The Gold emitted by the nanomaterials gradually altered biological condition and associated with individual injured area [63][64][65][66]. Furthermore, Gold is believed to shorten the time it takes fibroblasts to penetrate wounds.…”

Section: Antibacterial Properties and Cell Viability Analyses Of Dex/ss And Gold@dex/ssmentioning

confidence: 99%

Synergic Fabrication of Gold Nanoparticles Embedded Dextran/ Silk Sericin Nanomaterials for the Treatment and Care of Wound Healing

Chen

Bian

2021

J Clust Sci

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Gold-loaded nanoparticles are versatile nanomaterials that may be used in wound healing properties. The current study describes a wound dressing formulation focused on Gold-loaded Dextran/Silk Sericin nanoparticles. The Gold-loaded Dextran/Silk Sericin membranes were fabricated using Gold solutions inside the Dextran/Silk Sericin medium. The influence of various experimental conditions on Dextran/Silk Sericin nanoparticle formations were examined. The sizes of Dextran/Silk Sericin and Gold@Dextran/Silk Sericin nanoparticles were examined through the HR-SEM. Moreover, the efficacy antibacterial activity of Dextran/Silk Sericin and Gold-loaded Dextran/Silk Sericin nanoparticles was evaluated against the microorganisms gram-positive and negative. Furthermore, we observed the in vivo wound healing of wounds in skin using a mice model over a 16 days period. In this difference to the wounds of untreated mouse, quick healing was observed in the Gold-loaded Dextran/Silk Sericin nanoparticles-treated wounds with fewer injury. These results specify that Gold-loaded Dextran/Silk Sericin nanoparticles-based dressing material could be a ground-breaking nanomaterial having wound repair and implantations potential required for wound damages, which was proven using an animal model.

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Development of a silk fibroin-based multitask aerosolized nanopowder formula for efficient wound healing

Cited by 16 publications

References 46 publications

Silk Fibroin-Based Therapeutics for Impaired Wound Healing

Silk Fibroin-Based Therapeutics for Impaired Wound Healing

Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities

Synergic Fabrication of Gold Nanoparticles Embedded Dextran/ Silk Sericin Nanomaterials for the Treatment and Care of Wound Healing

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