Development of a Self-Nanoemulsifying Drug Delivery System (Snedds) From an Insulin Complex With Modified Phosphatidylcholine and Mucoadhesive Polysaccharide Coating as a Potential None-Invasive Treatment for Diabetes

Muñoz-Correa, María O.F.; México, Tecnológico Nacional de; Bravo-Alfaro, Diego A.; García, H.S.; García-Varela, Rebeca

doi:10.24275/rmiq/bio454

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…Different nanoparticles with differing ratios of surfactants and mucoadhesives were tested in gastric and intestinal simulated environments. The formulation with soybean phosphatidylcholine and 0.05% sodium alginate showed the highest insulin bioavailability of 46.3% …”

Section: Mucoadhesive (Ma) Formulations For Insulinmentioning

confidence: 99%

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Muco-Adhesive and Muco-Penetrative Formulations for the Oral Delivery of Insulin

Paul,

Bhuyan,

Balasoupramanien

et al. 2024

ACS Omega

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Insulin, a pivotal anabolic hormone, regulates glucose homeostasis by facilitating the conversion of blood glucose to energy or storage. Dysfunction in insulin activity, often associated with pancreatic β cells impairment, leads to hyperglycemia, a hallmark of diabetes. Type 1 diabetes (T1D) results from autoimmune destruction of β cells, while type 2 diabetes (T2D) stems from genetic, environmental, and lifestyle factors causing β cell dysfunction and insulin resistance. Currently, insulin therapy is used for most of the cases of T1D, while it is used only in a few persistent cases of T2D, often supplemented with dietary and lifestyle changes. The key challenge in oral insulin delivery lies in overcoming gastrointestinal (GI) barriers, including enzymatic degradation, low permeability, food interactions, low bioavailability, and long-term safety concerns. The muco-adhesive (MA) and muco-penetrative (MP) formulations aim to enhance oral insulin delivery by addressing these challenges. The mucus layer, a hydrogel matrix covering epithelial cells in the GI tract, poses significant barriers to oral insulin absorption. Its structure, composition, and turnover rate influence interactions with insulin and other drug carriers. Some of the few factors that influence mucoadhesion and mucopenetration are particle size, surface charge distribution, and surface modifications. This review discusses the challenges associated with oral insulin delivery, explores the properties of mucus, and evaluates the strategies for achieving excellent MA and MP formulations, focusing on nanotechnologybased approaches. The development of effective oral insulin formulations holds the potential to revolutionize diabetes management, providing patients with a more convenient and patient-friendly alternative to traditional insulin administration methods.

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Section: Mucoadhesive (Ma) Formulations For Insulinmentioning

confidence: 99%

“…The formulation with soybean phosphatidylcholine and 0.05% sodium alginate showed the highest insulin bioavailability of 46.3%. 36 4.2.4. Synthetic Polymer-Based Insulin Formulations.…”

Section: Chitosan and Itsmentioning

confidence: 99%

Muco-Adhesive and Muco-Penetrative Formulations for the Oral Delivery of Insulin

Paul,

Bhuyan,

Balasoupramanien

et al. 2024

ACS Omega

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“…These potential advantages of nanoemulsions over conventional emulsions make them attractive systems for application in food, cosmetics, and pharmaceuticals. They can act as carriers or delivery systems for lipophilic compounds such as nutraceuticals, drugs, flavors, antioxidants, and antimicrobial agents (Ghosh et al, 2013b;Muñoz-Correa et al, 2019;Kesisoglou et al, 2007;Sanguansri and Augustin, 2006;Weiss et al, 2008;Wissing et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effect of processing parameters on astaxanthin nanoemulsions with stearic acid using ultrasonic emulsification

Flores-Miranda¹,

Yáñez-Fernández²,

Martín‐Martínez³

2020

Rev.Mex.Ing.Quim.

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Development of a Self-Nanoemulsifying Drug Delivery System (Snedds) From an Insulin Complex With Modified Phosphatidylcholine and Mucoadhesive Polysaccharide Coating as a Potential None-Invasive Treatment for Diabetes

Abstract: Modelado de la biodegradación en biorreactores de lodos de hidrocarburos totales del petróleo intemperizados en suelos y sedimentos (Biodegradation modeling of sludge bioreactors of total petroleum hydrocarbons weathering in soil and sediments)

Cited by 2 publications

References 25 publications

Muco-Adhesive and Muco-Penetrative Formulations for the Oral Delivery of Insulin

Muco-Adhesive and Muco-Penetrative Formulations for the Oral Delivery of Insulin

Effect of processing parameters on astaxanthin nanoemulsions with stearic acid using ultrasonic emulsification

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