Effect of processing parameters on astaxanthin nanoemulsions with stearic acid using ultrasonic emulsification

Flores-Miranda, Grisel A.; Yáñez-Fernández, Jorge; Martín‐Martínez, Eduardo San

doi:10.24275/rmiq/alim936

Cited by 6 publications

(4 citation statements)

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“…According to Figure , AOA shows a reduction in 6.56% activity compared to that of a fresh sample. This statement is supported by Flores-Miranda et al, who reported a 50% reduction in the antioxidant activity of astaxanthin-encapsulated nanoemulsions over a period of 28 days compared to that of a fresh sample. Figure also shows an 8.4% reduction in emulsion stability compared to that of a fresh sample.…”

Section: Resultsmentioning

confidence: 97%

Optimizing Fucoidan Encapsulation in a W₁/O/W₂ Double Emulsion through an Ultrasound-Assisted Process and Response Surface Methodology

Bagale,

Kadi,

Malinin

et al. 2024

Ind. Eng. Chem. Res.

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Fucoidan from marine brown algae has been known to exert several health benefits, primarily antioxidant and anticancer properties. The primary goal of this research was to encapsulate fucoidan in stable water-in-oil-in-water (W1/O/W2) emulsions using an ultrasound technique. We optimized primary emulsion and double emulsion formulations using the response surface methodology (RSM). The formulation for primary emulsion and double emulsion is based on lecithin as the lipophilic surfactant concentration (0–5%), sonication time (20, 25, and 30 min), and hydrophilic surfactant Tween 80 (0–2.5%), respectively. Both emulsions are further characterized based on variables such as drop size, antioxidant activity, gravitational stability, peroxide value, and encapsulation efficiency. Based on RSM, the double emulsion with optimum conditions (sonication time, 25 min; internal emulsifier lecithin, 2.6%, sonication amplitude, 71%; and external emulsifier Tween 80, 1.2%) showed a small drop size (726 nm), antioxidant activity (91.33%), a stability of 85.33%, and an encapsulation efficiency of 90.36. Further optimized and stable double emulsions were assayed during 45 days of storage at a temperature of 37 °C. The results showed a slight change with minimal percentage loss of encapsulation efficiency from 90.36 to 86.78%.

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Section: Resultsmentioning

confidence: 97%

Optimizing Fucoidan Encapsulation in a W₁/O/W₂ Double Emulsion through an Ultrasound-Assisted Process and Response Surface Methodology

Bagale,

Kadi,

Malinin

et al. 2024

Ind. Eng. Chem. Res.

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“…On the other hand, liposomes have been used in the treatment of osteoarthritis, but there is no literature on the evaluation of the effect of astaxanthin-loaded liposomes on bone health. Previous studies have indicated that the biological efficacy of the astaxanthin extracts may change with the manner of storage and extraction [1,21]. In the present study, astaxanthin (asta)-loaded liposomes prepared using soybean phosphatidylcholine (SPC) were expected to maintain the bioactivity of the astaxanthin extract and increase the absorption rate in the bone cells.…”

Section: Introductionmentioning

confidence: 86%

Development of Astaxanthin-Loaded Nanosized Liposomal Formulation to Improve Bone Health

Chang

Shao

Huang³

et al. 2022

Pharmaceuticals

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Astaxanthin is a xanthophyll carotenoid commonly found in marine organisms. Due to its super antioxidative ability, astaxanthin has been widely applied as a human nutraceutical supplement for health benefits. In order to enhance the bioavailability of astaxanthin, we used soybean phosphatidylcholine to encapsulate astaxanthin for liposomal formation. The physical properties of astaxanthin (asta)-loaded liposomes were determined by particle size, encapsulation efficiency and polydispersity index. The results revealed that the particle sizes of asta-loaded liposomes with various concentrations exhibited mean diameters in the range of 109 to 134 nm and had a narrow PDI value. As expected, the entrapment efficiency of liposomes loaded with a low concentration of astaxanthin (0.05 μg/mL) was 89%, and that was reduced to 29% for 1.02 μg/mL asta loading. Alizarin red staining and calcium content measurement showed that there was a significant reduction in calcium deposition for 7F2 osteoblasts treated with asta-loaded liposomes (0.25–1.02 μg/mL) in comparison with the cells treated with drug-free liposomes and mineralization medium (MM). Although liposomal formulation can reduce the cytotoxicity of astaxanthin and possess antioxidant, anti-inflammatory and anti-osteoclastogenic activities in RAW264.7 macrophages, asta-loaded liposomes with high concentrations may suppress ALP activity and mineralization level in 7F2 osteoblasts. Therefore, astaxanthin extract may be able to protect bones against oxidative stress and inflammation through liposomal formulation.

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“…Oil-in-water nanoemulsions and microemulsions are two basic colloidal dispersion systems suitable for the delivery of lipophilic β-carotene for food applications. The literature also reports several techniques for the preparation of micro/nanoemulsions, such as emulsion phase inversion [292], high-pressure homogenization [293], microfluidization [144,294], supercritical fluid methods [145,295], spontaneous emulsification [296] and phase-inversion temperature [297].…”

Section: Micro/nanoemulsionsmentioning

confidence: 99%

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

et al. 2021

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Nanotechnology has opened new opportunities for delivering bioactive agents. Their physiochemical characteristics, i.e., small size, high surface area, unique composition, biocompatibility and biodegradability, make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers have some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has rapidly evolved, with a plethora of innovative nanoengineered materials now being in use, including micelles, nano/microemulsions, liposomes, niosomes, solidlipid nanoparticles, nanostructured lipids and nanostructured carriers. These nanodelivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nanodelivery systems adopted for developing functional foods, depicting their classifications, compositions, preparation methods, challenges, release and absorption of β-carotene in the gastrointestinal tract (GIT) and possible risks and future prospects.

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Effect of processing parameters on astaxanthin nanoemulsions with stearic acid using ultrasonic emulsification

Abstract: Modelado de la biodegradación en biorreactores de lodos de hidrocarburos totales del petróleo intemperizados en suelos y sedimentos (Biodegradation modeling of sludge bioreactors of total petroleum hydrocarbons weathering in soil and sediments)

Cited by 6 publications

References 50 publications

Optimizing Fucoidan Encapsulation in a W₁/O/W₂ Double Emulsion through an Ultrasound-Assisted Process and Response Surface Methodology

Optimizing Fucoidan Encapsulation in a W₁/O/W₂ Double Emulsion through an Ultrasound-Assisted Process and Response Surface Methodology

Development of Astaxanthin-Loaded Nanosized Liposomal Formulation to Improve Bone Health

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

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Effect of processing parameters on astaxanthin nanoemulsions with stearic acid using ultrasonic emulsification

Abstract: Modelado de la biodegradación en biorreactores de lodos de hidrocarburos totales del petróleo intemperizados en suelos y sedimentos (Biodegradation modeling of sludge bioreactors of total petroleum hydrocarbons weathering in soil and sediments)

Cited by 6 publications

References 50 publications

Optimizing Fucoidan Encapsulation in a W1/O/W2 Double Emulsion through an Ultrasound-Assisted Process and Response Surface Methodology

Optimizing Fucoidan Encapsulation in a W1/O/W2 Double Emulsion through an Ultrasound-Assisted Process and Response Surface Methodology

Development of Astaxanthin-Loaded Nanosized Liposomal Formulation to Improve Bone Health

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

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Optimizing Fucoidan Encapsulation in a W₁/O/W₂ Double Emulsion through an Ultrasound-Assisted Process and Response Surface Methodology

Optimizing Fucoidan Encapsulation in a W₁/O/W₂ Double Emulsion through an Ultrasound-Assisted Process and Response Surface Methodology