Development of a RP-HPLC method for simultaneous determination of reference markers used for in-situ rat intestinal permeability studies

A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies

“…Pharmaceutical analyses are very important in the pharmaceutical industry because of the need for accurate and precise analytical methods to analyze drugs, impurities and drug metabolites in drug development processes. Permeability studies are one of the applications of pharmacokinetic studies and require the analysis of drug substances in the transport media to determine the permeability of targeted drugs [6] . According to the guidelines, permeability studies could be performed utilizing human pharmacokinetic studies.…”

Piroksikamın pKa Değerinin Yüksek Performanslı Sıvı Kromatografisi ile Belirlenmesi

“…Bir sıvıda çözünebilen bileşenlerin (ilaç etken maddeleri, aminoasitler, şekerler, vitaminler, antibiyotikler, pestisitler, gıda katkı maddeleri, gıda toksinleri vb.) bu teknik ile nitel ve nicel olarak hassas, hızlı ve güvenilir şekilde tespit edilmesi mümkündür (Sezgin, Arli, & Can, 2021;Soyseven, Kaynak, Çelebier, Aboul-Enein, & Arli, 2020, Moldoveanu & David, 2002Moldoveanu & David, 2013a;Snyder, Kirkland, & Dolan, 2011).…”