A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies

Reçber, Tuba; Timur, Selin Seda; Erdoğan, Sevilay; Yalçın, Fatma; Karabulut, Tutku Ceren; Gürsoy, R. Neslihan; Eroğlu, Hakan; Kır, Sedef; Nemutlu, Emirhan

doi:10.1016/j.jpba.2022.114693

Cited by 38 publications

(42 citation statements)

References 17 publications

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“…All the results obtained by the proposed HPLC method were compared with those obtained by the reported method for MOL, 23 and no signicant difference between the methods was observed, as shown in Table 4.…”

Section: Discussionmentioning

confidence: 94%

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Development and validation of molnupiravir assessment in bulk powder and pharmaceutical formulation by the RP-HPLC-UV method

et al. 2022

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Section: Discussionmentioning

confidence: 94%

“…The results were investigated by comparing them with those from the assays of freshly prepared solutions of reference standards. 23 …”

Section: Methods Validationmentioning

confidence: 99%

Development and validation of molnupiravir assessment in bulk powder and pharmaceutical formulation by the RP-HPLC-UV method

et al. 2022

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“…The separation of the peaks of the analyte from its degradation products is one of the most common ways to verify the selectivity of a chromatographic methodology [28,29]. The methods in the literature differ regarding the degradation of FA under different pH conditions.…”

Section: Selectivitymentioning

confidence: 99%

A high‐performance liquid chromatography method for simultaneous quantification of metformin and ferulic acid in solid dosage forms

Júnior

Muniz

Almeida

et al. 2022

J of Separation Science

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Metformin is one of the most commonly used drugs in the world for the treatment of type 2 diabetes, while ferulic acid is a molecule that stands out for its antioxidant potential. Recent studies demonstrate hypoglycemic synergy between these molecules. The objective of this study is to develop and validate an analytical methodology by high‐performance liquid chromatography for the simultaneous quantification of these drugs in pharmaceutical formulations. The method used an octadecylsilane column and a mobile phase composed of 6 mM sodium lauryl sulfate in 15 mM phosphate buffer:ACN (65:35). Ferulic acid and metformin were monitored at 232 nm, with a mobile phase flow rate of 1 ml/min and oven temperature at 40°C. The method was linear in the range of 5–25 μg/ml for both molecules. In the presence of degradation products, satisfactory selectivity was achieved. Accuracy values were close to 100% and standard deviations in precision were less than 2%. In the robustness evaluation, the proposed variations did not interfere with the quantification. Therefore, it is concluded that the present method can be safely applied to the quality control of ferulic acid and metformin raw materials, as well as when they are combined in pharmaceutical formulations.

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“…Consequently, specific, sensitive, and selective electroanalytical methods for detecting MPV are urgently required for regular quality control in pharmaceutical formulations and pharmacokinetic and metabolic research in biological samples. However, a search of the literature for traditional analytical techniques for MPV showed that only two studies had been used mainly for MPV detection in pharmaceutical and biological samples, including highperformance liquid chromatographic (HPLC) [5] and liquid chromatography-tandem mass spectrometry (LC-MS/MS). [6] However, these approaches suffer from main problems, including a time-consuming performance, high cost, limited selectivity, sensitivity, and stability.…”

Section: Introductionmentioning

confidence: 99%

An Electrochemical Sensor for Molnupiravir Based on a Metal‐Organic Framework Composited with Poly(3,4‐ethylene dioxythiophene): Poly(styrene sulfonate)

et al. 2022

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Herein, a novel composite based on Cu3(BTC)2 and poly (3, 4‐ethylene dioxythiophene): poly (styrene sulfonate) with ethylene glycol was successfully synthesized and then modified on the glassy carbon electrode (Cu‐BTC@EG‐PEDOT : PSS/GCE) to detect Molnupiravir (MPV) as an anti‐covid drug. The as‐prepared electrode effectively enhanced the electron transfer between the electrode and the analyte, leading to a more sensitive response in the MPV oxidation under optimum conditions. Under the optimum conditions, the developed electrochemical sensor has the advantages in terms of a wide linear dynamic range (0.1 up to 63.3 μM) and a low detection limit (0.0713 μM) as well as high selectivity in the presence of several interferences. The newly developed sensor was applied to accurately determine MPV in trace amounts in both environmental and pharmaceutical samples, indicating satisfactory recoveries in the range from 98.30 to 101.41 % for capsules and 96.20 to 104.67 % for river water. The developed sensor demonstrated an excellent electrochemical response for MPV determination owing to the synergistic effects between metal‐organic frameworks and a conductive polymer. Hence, the present sensor holds great promise for identifying and quantifying antiviral drugs and extends the application of MOF composites in sensing applications.

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A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies

Cited by 38 publications

References 17 publications

Development and validation of molnupiravir assessment in bulk powder and pharmaceutical formulation by the RP-HPLC-UV method

Development and validation of molnupiravir assessment in bulk powder and pharmaceutical formulation by the RP-HPLC-UV method

A high‐performance liquid chromatography method for simultaneous quantification of metformin and ferulic acid in solid dosage forms

An Electrochemical Sensor for Molnupiravir Based on a Metal‐Organic Framework Composited with Poly(3,4‐ethylene dioxythiophene): Poly(styrene sulfonate)

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