An Electrochemical Sensor for Molnupiravir Based on a Metal‐Organic Framework Composited with Poly(3,4‐ethylene dioxythiophene): Poly(styrene sulfonate)

Abstract

Herein, a novel composite based on Cu3(BTC)2 and poly (3, 4‐ethylene dioxythiophene): poly (styrene sulfonate) with ethylene glycol was successfully synthesized and then modified on the glassy carbon electrode (Cu‐BTC@EG‐PEDOT : PSS/GCE) to detect Molnupiravir (MPV) as an anti‐covid drug. The as‐prepared electrode effectively enhanced the electron transfer between the electrode and the analyte, leading to a more sensitive response in the MPV oxidation under optimum conditions. Under the optimum conditions, the developed electrochemical sensor has the advantages in terms of a wide linear dynamic range (0.1 up to 63.3 μM) and a low detection limit (0.0713 μM) as well as high selectivity in the presence of several interferences. The newly developed sensor was applied to accurately determine MPV in trace amounts in both environmental and pharmaceutical samples, indicating satisfactory recoveries in the range from 98.30 to 101.41 % for capsules and 96.20 to 104.67 % for river water. The developed sensor demonstrated an excellent electrochemical response for MPV determination owing to the synergistic effects between metal‐organic frameworks and a conductive polymer. Hence, the present sensor holds great promise for identifying and quantifying antiviral drugs and extends the application of MOF composites in sensing applications.

A low-cost voltammetric sensor based on multi-walled carbon nanotubes for highly sensitive and accurate determination of nanomolar levels of the anticancer drug Ribociclib in bulk and biological fluids

“…To garner an additional understanding of the electrochemical properties, we employed the Randles-Sevcik equation (eqn (S1) †) to ascertain the electrochemical active surface area (ECSR) of both the bare GCE and MWCNTs/GCE electrodes. 26 The evaluation of MWCNTs/GCE was accomplished by recording the redox peak current at varying scan rates, ranging from 10 to 300 mV s −1 (Fig. S1 and S2 †).…”

Electrochemical Investigations and Molecular Docking Analysis to Evaluate the Molnupiravir-Calf Thymus dsDNA Interaction

“…11 According to another study on the determination of MLP by Erk et al, they used the novel composite Cu 3 (BTC) 2 and poly (3, 4-ethylene dioxythiophene): poly (styrene sulfonate) with ethylene glycol for the modification of GCE. 12 With this modified electrode that enhances electron transfer, the detection limit was found to be 0.0713 μM with a 0.1-63.3 μM linear range in the pH 3.0 Britton-Robinson buffer solution. 12 Also, the developed sensor was applied to environmental and pharmaceutical samples.…”

“…12 With this modified electrode that enhances electron transfer, the detection limit was found to be 0.0713 μM with a 0.1-63.3 μM linear range in the pH 3.0 Britton-Robinson buffer solution. 12 Also, the developed sensor was applied to environmental and pharmaceutical samples.…”

Surface engineering of carbon microspheres with nanoceria wrapped on MWCNTs: a dual electrocatalyst for simultaneous monitoring of molnupiravir and paracetamol

“…Many methods are described in the literature that can measure MPV or PCM using HPLC, [12][13][14] UV spectrophotometry, 15,16 and electrochemical methods. [17][18][19][20][21][22][23][24][25][26][27][28] However, except for electrochemical methods, all other analytical methods are complicated, tedious, timeconsuming, and expensive. Electrochemical methods are timesaving, simple, real-time, user-friendly, and economically worthwhile.…”