Development of a recombinant hCG-specific single chain immunotoxin cytotoxic to hCG expressing cancer cells

Nand, Kripa N.; Gupta, Jagdish C.; Panda, Amulya K.; Jain, Swatantra Kumar

doi:10.1016/j.pep.2014.10.008

Cited by 10 publications

(3 citation statements)

References 24 publications

(28 reference statements)

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“…Its role in normal tissue seems to be mainly autoregulatory exerting growth-promoting activity [ 46 ]. However, the β-subunit of HCG, and to a lesser extent heterodimeric HCG, are also produced by several non-trophoblastic tumors like breast cancer, cervical carcinoma, vaginal cancer, bladder cancer, lung cancer, colorectal carcinoma, prostate cancer and gastric cancer [ 44 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

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Human Chorionic Gonadotropin and Breast Cancer

Schüler-Toprak

Treeck

Ortmann

2017

IJMS

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Breast cancer is well known as a malignancy being strongly influenced by female steroids. Pregnancy is a protective factor against breast cancer. Human chorionic gonadotropin (HCG) is a candidate hormone which could mediate this antitumoral effect of pregnancy. For this review article, all original research articles on the role of HCG in breast cancer were considered, which are listed in PubMed database and were written in English. The role of HCG in breast cancer seems to be a paradox. Placental heterodimeric HCG acts as a protective agent by imprinting a permanent genomic signature of the mammary gland determining a refractory condition to malignant transformation which is characterized by cellular differentiation, apoptosis and growth inhibition. On the other hand, ectopic expression of β-HCG in various cancer entities is associated with poor prognosis due to its tumor-promoting function. Placental HCG and ectopically expressed β-HCG exert opposite effects on breast tumorigenesis. Therefore, mimicking pregnancy by treatment with HCG is suggested as a strategy for breast cancer prevention, whereas targeting β-HCG expressing tumor cells seems to be an option for breast cancer therapy.

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Section: Resultsmentioning

confidence: 99%

“…In other immunological approaches directed against ectopically expressed β-HCG, a monoclonal antibody against β-HCG was conjugated with cytotoxic drugs like curcumin or combined with Pseudomonas exotoxin in a recombinant immunotoxin. Both strategies in vitro succeeded in high killing rates of β-HCG -expressing cancer cells [ 47 , 113 ].…”

Section: Resultsmentioning

confidence: 99%

Human Chorionic Gonadotropin and Breast Cancer

Schüler-Toprak

Treeck

Ortmann

2017

IJMS

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“…The same antibody was used for the development of an immunotoxin targeting hCG-expressing cancer cells (152). The VH and VL domains of the full antibody were linked together to form the scFv fragment (scFv PIPP).…”

Section: Anti-gonadotropin Antibodies As Therapeutic Agentsmentioning

confidence: 99%

Modulation of Gonadotropins Activity by Antibodies

Kara¹,

Dupuy²,

Bouillon

et al. 2019

Front. Endocrinol.

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Gonadotropins are essential for reproduction control in humans as well as in animals. They are widely used all over the world for ovarian stimulation in women, spermatogenesis stimulation in men, and ovulation induction and superovulation in animals. Despite the availability of many different preparations, all are made of the native hormones. Having different ligands with a wide activity range for a given receptor helps better understand its molecular and cellular signaling mechanisms as well as its physiological functions, and thus helps the development of more specific and adapted medicines. One way to control the gonadotropins' activity could be the use of modulating antibodies. Antibodies are powerful tools that were largely used to decipher gonadotropins' actions and they have shown their utility as therapeutics in several other indications such as cancer. In this review, we summarize the inhibitory and potentiating antibodies to gonadotropins, and their potential therapeutic applications.

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Preparation of a novel EGFR specific immunotoxin and its efficacy of anti-colorectal cancer in vitro and in vivo

Deng

Zhang

et al. 2021

Clin Transl Oncol

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Development of a recombinant hCG-specific single chain immunotoxin cytotoxic to hCG expressing cancer cells

Cited by 10 publications

References 24 publications

Human Chorionic Gonadotropin and Breast Cancer

Human Chorionic Gonadotropin and Breast Cancer

Modulation of Gonadotropins Activity by Antibodies

Preparation of a novel EGFR specific immunotoxin and its efficacy of anti-colorectal cancer in vitro and in vivo

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