Development of a Rapid LC–MS–MS Method for Multi-Class Determination of 14 Coccidiostat Residues in Eggs and Chicken

Multiclass screening method based on solvent extraction and liquid chromatography–tandem mass spectrometry for the determination of antimicrobials and mycotoxins in egg

“…However, in recent years, there is a growing tendency to develop antibiotic multiclass LC-MS methods [12,[16][17][18][19][20][21][22][23][24][25][26]. These studies report the simultaneous determination of the following antimicrobials, respectively: ionophores and macrolides (MCs) [16]; TCs and FQs [18]; SAs, TCs, FQs, ␤-lactams (penicillins and cephalosporins) [17]; coccidiostats and ionophores [19,21,25]; benzimidazoles, MCs, penicillins, FQs, SAs, TCs, nitroimidazoles, coccidiostat, ionophores and amphenicols [20]; TCs, MCs, FQs, SAs and anthelmintics [22]; ionophores, MCs and lincosamides [23]; 105 drug residues including benzimidazoles, nitromidazoles, FQs, SAs, TCs [24]; 41 compounds belonging to SAs, diaminopyridine derivates, FQs, TCs, MCs, penicillins and lincosamides [26].…”

Ultra-sensitive Determination of Salinomycin in Serum Using ICP-MS with Nanoparticles

“…10 Various analytical methods to determine salinomycin were developed so far, such as enzymelinked immunosorbent assay (ELISA) 11 and chromatographyhyphenated mass spectrometry. [12][13][14][15][16] The organic mass spectrometry showed high resolution and sensitivity with the detection limit of 0.01 μg kg . ELISA offers fast analysis but it suffers from relatively poor detection limit in the range of 50 to 300 μg kg .…”

Current trends in sample preparation for growth promoter and veterinary drug residue analysis

“…Since early 2000s, LC-MS/MS has found widespread application in the analysis of anticoccidials and has allowed the simultaneous detection of their residues at low levels [212]. In addition, some groups have developed assays that additionally include nitroimidazoles [363,364]. However, the nitroimidazoles are normally analysed separately.…”

“…Na2SO4 and extracted four ionophore residues with prior to ACN prior to silica SPE [366]. This method has since been applied by several groups to the analysis of multiple anticoccidials residues from egg, liver and muscle [363,367,368]. Mortier et al developed a simple procedure for isolating anticoccidials residues from egg samples without the need for sample purification [364,369].…”