Development of a Promising Antitumor Compound Based on Rhodium(II) Succinate Associated with Iron Oxide Nanoparticles Coated with Lauric Acid/Albumin Hybrid: Synthesis, Colloidal Stability and Cytotoxic Effect in Breast Carcinoma Cells

Silva, Matheus Oliveira da; Carneiro, Marcella Lemos Brettas; Siqueira, Joseílma Luciana Neves; Báo, Sônia Nair; Souza, Aparecido Ribeiro de

doi:10.1166/jnn.2018.15021

Cited by 12 publications

(4 citation statements)

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“…Nowadays, this fatty acid has been extensively used in many indurstries, e.g., Food, Medicine, and Daily Chemical etc [23,24]. With the deepening of the related researches, DDA has been found to exert a marked inhibitory effect on the growth of some tumor cells like prostate cancer, breast cancer, stomach cancer and lung cancer [25][26][27]. However, the anticancer effects of DDA against liver cancer cells remain unclear.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Dodecanoic acid induces oxidative stress-mediated apoptotic death in liver cancer cells through mitochondrial pathway

chen

Guo

et al. 2020

Preprint

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Background Dodecanoic acid (DDA), a medium chain saturated fatty acids, has been reported to have anticancer activity in reproductive system cancer and some digestive tract cancers. However, the role and the underlying mechanism of DDA in liver cancer have been rarely defined. Methods Mouse liver cancer Hepa 1–6 cells were administrated with DDA in this present study. Apoptosis, cell cycle analysis, mitochondrial membrane potential (MMP) and ATP content were determined by flow cytometry; GSH availability, ROS level and SOD activity was assessed by a microplate reader; Bcl-2, Bax and Caspase-3 protein levels were analyzed by western blot. Results 0.5 mM DDA was identified as the ideal concentration for investigation and could time-dependently inhibit cell viability. DDA-treated cells had a significant, time-dependent increase in cell apoptotic rate in spite of an accumulation of the cells in S + G2/M phase of the cell cycle. The enhanced level of ROS, depletion of GSH and the reduced activity of SOD in DDA-treated cells indicated the generation of oxidative stress; mitochondrial dysfunction was evidenced by the dissipation of MMP of and the reduction in ATP content. Cell death via mitochondrial pathway was indicated by the reduced Bcl-2/Bax ratio and the increased level of caspase-3 protein. Conclusions Taken together, DDA effectively triggers oxidative stress-induced death in liver cancer cells by disturbing the structure and function of mitochondria. The findings provide an in-depth insight into the potential action mechanism of DDA on liver cancer.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Dodecanoic acid induces oxidative stress-mediated apoptotic death in liver cancer cells through mitochondrial pathway

chen

Guo

et al. 2020

Preprint

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“…The oncostatic effect may be increased by encapsulation to protect LaA from possible degradation in the extracellular environment [171]. LaA may also be used in a coating of nanoparticles to improve intracellular retention and drug delivery [172][173][174].…”

Section: Stearic Acidmentioning

confidence: 99%

Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence

Bojková

Winklewski

Wszędybył-Winklewska

2020

IJMS

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A high-fat diet (HFD) induces changes in gut microbiota leading to activation of pro-inflammatory pathways, and obesity, as a consequence of overnutrition, exacerbates inflammation, a known risk factor not only for cancer. However, experimental data showed that the composition of dietary fat has a greater impact on the pathogenesis of cancer than the total fat content in isocaloric diets. Similarly, human studies did not prove that a decrease in total fat intake is an effective strategy to combat cancer. Saturated fat has long been considered as harmful, but the current consensus is that moderate intake of saturated fatty acids (SFAs), including palmitic acid (PA), does not pose a health risk within a balanced diet. In regard to monounsaturated fat, plant sources are recommended. The consumption of plant monounsaturated fatty acids (MUFAs), particularly from olive oil, has been associated with lower cancer risk. Similarly, the replacement of animal MUFAs with plant MUFAs decreased cancer mortality. The impact of polyunsaturated fatty acids (PUFAs) on cancer risk depends on the ratio between ω-6 and ω-3 PUFAs. In vivo data showed stimulatory effects of ω-6 PUFAs on tumour growth while ω-3 PUFAs were protective, but the results of human studies were not as promising as indicated in preclinical reports. As for trans FAs (TFAs), experimental data mostly showed opposite effects of industrially produced and natural TFAs, with the latter being protective against cancer progression, but human data are mixed, and no clear conclusion can be made. Further studies are warranted to establish the role of FAs in the control of cell growth in order to find an effective strategy for cancer prevention/treatment.

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“…Despite the myriad of applications of rhodium, limited research has been conducted into the antimicrobial aspect of nanoparticles derived from or containing rhodium. Many studies have shown the antitumor effects of rhodium nanoparticle constructs [131][132][133], catalytic activity [134][135][136], as well as their potential application as detectors [137][138][139]. Although there is limited antimicrobial research in rhodium-derived nanoparticles, the enhanced activity of these materials may indicate an untapped source of antimicrobial treatment for the future.…”

Section: Rhodiummentioning

confidence: 99%

A review of the antimicrobial potential of precious metal derived nanoparticle constructs

et al. 2019

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The field of nanotechnology is rapidly growing. The promise of pharmacotherapeutics emerging from this vast field has drawn the attention of many researchers. However, with the increase in the prevalence of antibiotic resistant microorganisms, the manifestations of these promises are needed now more than ever. Many have postulated the antimicrobial potential of nanoparticle constructs derived from precious metals/noble metals nanoparticles (NMNPs), such as silver nanoparticles that show activity against multidrug resistant bacteria. In this review we will evaluate the current studies and explore the data to obtain a clear picture of the potential of these particles and the validity of the claims of drug resistant treatments with NMNPs.

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Development of a Promising Antitumor Compound Based on Rhodium(II) Succinate Associated with Iron Oxide Nanoparticles Coated with Lauric Acid/Albumin Hybrid: Synthesis, Colloidal Stability and Cytotoxic Effect in Breast Carcinoma Cells

Cited by 12 publications

References 0 publications

RETRACTED: Dodecanoic acid induces oxidative stress-mediated apoptotic death in liver cancer cells through mitochondrial pathway

RETRACTED: Dodecanoic acid induces oxidative stress-mediated apoptotic death in liver cancer cells through mitochondrial pathway

Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence

A review of the antimicrobial potential of precious metal derived nanoparticle constructs

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