Development of a potential probiotic yoghurt using selected anti-inflammatory lactic acid bacteria for prevention of colitis and carcinogenesis in mice

Carmen, Silvina del; LeBlanc, Alejandra de Moreno de; LeBlanc, Jean Guy

doi:10.1111/jam.13213

Cited by 23 publications

(18 citation statements)

References 39 publications

(38 reference statements)

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“…These have also been shown to possess anti-aging and antiinflammatory properties [6,7]. Lactobacillus can also relieve intestinal inflammation by secreting metabolites that impart stimulatory effects on intestinal mucosal lymph nodes, thereby enhancing the activity of immune systemrelated cells and macrophages [8]. Lactic acid bacteria may be directly used or acquired through the consumption of fermented food.…”

Section: Introductionmentioning

confidence: 99%

Preventative effects of Lactobacillus plantarum YS-3 on oxazolone-induced BALB/c colitis in mice

Xia

Zhang²,

Qian

et al. 2018

Appl Biol Chem

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In this study, the preventative effects of Lactobacillus plantarum YS-3 (LP-YS3) on colitis were studied using an in vitro animal experiment. Oxazolone was administered to BALB/c mice to induce colitis, and the preventive effects of LP-YS3 were determined using serum-and tissue-related indexes. The mice treated with LP-YS3 showed a significant decrease (p \ 0.05) in disease activity index for colitis by inhibiting colon shortening and increasing colon weight/length ratio. The application of LP-YS3 resulted in a significant reduction in myeloperoxidase, nitric oxide, and malondialdehyde activities and a decrease in glutathione activity (p \ 0.05) in mouse colon tissues. LP-YS3 also significantly increased serum interleukin-2 and reduced interleukin-10 cytokines levels in mice (p \ 0.05). Reverse transcription-polymerase chain reaction and western blot assays showed that LP-YS3 application resulted in a significant increase in neuronal nitric oxide synthase, endothelial nitric oxide synthase, c-Kit, and stem cell factor expressions and a decrease in inducible nitric oxide synthase, interleukin-8, and C-X-C motif chemokine receptor 2 expressions in mouse colonic tissues (p \ 0.05). These findings indicate that LP-YS3 imparts preventative effects on oxazoloneinduced colitis in mice. Keywords Lactobacillus plantarum YS-3 Á Oxazolone Á Colitis Á Chemokine receptor Á Expression Xia Feng and Jing Zhang have contributed equally to this work.

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Section: Introductionmentioning

confidence: 99%

Preventative effects of Lactobacillus plantarum YS-3 on oxazolone-induced BALB/c colitis in mice

Xia

Zhang²,

Qian

et al. 2018

Appl Biol Chem

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“…Recently, new types of yoghurt fermented with any kinds of LAB or S. thermophilus are also produced as popular dairy products. Previous studies showed these probiotic strains regulate inflammation, suggesting their ability to modulate the function of immune-related cells [ 16 , 17 , 18 , 19 , 20 ]. The aim of this study is to provide information and clarify the characteristics of yoghurt-derived LAB strains for immune-modulatory effects, especially on the activation of dendritic cells (DCs) and T helper (Th) cells in the intestine.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Intestinal Immune Cell Function by Lactic Acid Bacteria for Dairy Products

Kamiya

Watanabe

Makino³

et al. 2016

Microorganisms

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Lactic acid bacteria (LAB) form a major component of gut microbiota and are often used as probiotics for fermented foods, such as yoghurt. In this study, we aimed to evaluate immunomodulatory activity of LAB, especially that of Lactobacillus bulgaricus ME-552 (ME552) and Streptococcus thermophilus ME-553 (ME553). In vivo/in vitro assay was performed in order to investigate their effects on T cell function. After oral administration of ME553 to C57BL/6 mice, the amount of both interferon γ (IFN-γ) and interleukin 17 (IL-17) produced by cluster of differentiation (CD) 4+ T cells from Peyer’s patches (PPs) were significantly enhanced. On the other hand, ME552 only up-regulated the production of IL-17 from PP cells. The extent of induction for IFN-γ production differed between ME552 and ME553. These results suggest that LAB modulate T cell effector functions and mucosal immunity.

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“…Prostaglandin E2 is a prostaglandin with complex biological activity, which is involved in GI-RI inflammation [18]. PGE2 synthase is the last key enzyme in the synthesis of prostaglandin E2.…”

Section: Discussionmentioning

confidence: 99%

“…Prostaglandin E2 escapes through facilitated diffusion and binds to E-prostanoid 1 -4 in an autocrine or paracrine manner. In this way, it may alter the levels of intracellular second messengers, and send signals to cells, causing a series of physiological or pathophysiological changes [18].…”

Section: Discussionmentioning

confidence: 99%

Gambir Extract (Uncaria Gambir) Decreases Inflammatory Response and Increases Gastric Mucosal Integrity in Wistar Rats - Model Gastritis

Oswari¹,

Hidayat²,

Fatmawati³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Uncaria gambir (local name: gambir) is a plant native to Sumatera, Malaya and Borneo. This plant is potential as local wisdom for therapeutics. In Sumatera, gambir was used as a traditional treatment for fever, diarrhoea, diabetics and wound healing. AIM: To explore the efficacy of gambir extract on TNF alpha level, prostaglandin E2 level, lesson area, body weight, lipid profile and leptin level in Wistar rat-model gastritis. METHODS: This study was an experimental study, with a pre-post-test control group design. The subjects in this study were 30 male rats, 8 weeks old, weight 150-200 gram. Rats were administered with gambir extract at the dose of 20, 40 and 80 mg/kg BW/day for 3 days. Gambir was extracted by maceration methods. Statistical analysis was performed by SPSS 18. RESULTS: Gambir extract at the dose of 80 mg/kg BW exhibited the highest efficacy in reducing TNF alpha level, lesion area and increasing prostaglandin E2 level compared to gambir extract at doses of 20 mg/kg BW, 400 mg/kg BW, negative control, and positive control. CONCLUSION: Gambir extract was effective in reducing TNF alpha level, lesson area, and increasing prostaglandin E2 level in Wistar rat-model gastritis.

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Development of a potential probiotic yoghurt using selected anti-inflammatory lactic acid bacteria for prevention of colitis and carcinogenesis in mice

Abstract: This new yoghurt could thus be considered a probiotic food and be useful as a complement to current treatment protocols for inflammatory bowel diseases and colon cancer, a first since there are no current functional foods specifically oriented for these patients.

Cited by 23 publications

References 39 publications

Preventative effects of Lactobacillus plantarum YS-3 on oxazolone-induced BALB/c colitis in mice

Preventative effects of Lactobacillus plantarum YS-3 on oxazolone-induced BALB/c colitis in mice

Improvement of Intestinal Immune Cell Function by Lactic Acid Bacteria for Dairy Products

Gambir Extract (Uncaria Gambir) Decreases Inflammatory Response and Increases Gastric Mucosal Integrity in Wistar Rats - Model Gastritis

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