Development of a Portable Electrical Impedance Tomography System for Biomedical Applications

Xu, Zifei; Yao, Jiafeng; Wang, Zheng; Li, Yanli; Wang, Hao; Chen, Bai; Wu, Hongtao

doi:10.1109/jsen.2018.2864539

Cited by 78 publications

(49 citation statements)

References 29 publications

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“…Given the issue of contraction in some collagen‐based 3D models, as well as the presence of contraction in wound healing models (Lotz et al, 2017), a potential application for EIT could be to monitor contraction over time or after wounding in these models. Others have designed similar set ups to those demonstrated in Figure 7, with the eventual aim of monitoring cell cultures, but have not yet tested it using cells (Xu et al, 2018).…”

Section: D Impedance Tomographymentioning

confidence: 99%

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Three‐Dimensional (3D) cell culture monitoring: Opportunities and challenges for impedance spectroscopy

León

Pupovac

McArthur

2020

Biotech & Bioengineering

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Three‐dimensional (3D) cell culture has developed rapidly over the past 5–10 years with the goal of better replicating human physiology and tissue complexity in the laboratory. Quantifying cellular responses is fundamental in understanding how cells and tissues respond during their growth cycle and in response to external stimuli. There is a need to develop and validate tools that can give insight into cell number, viability, and distribution in real‐time, nondestructively and without the use of stains or other labelling processes. Impedance spectroscopy can address all of these challenges and is currently used both commercially and in academic laboratories to measure cellular processes in 2D cell culture systems. However, its use in 3D cultures is not straight forward due to the complexity of the electrical circuit model of 3D tissues. In addition, there are challenges in the design and integration of electrodes within 3D cell culture systems. Researchers have used a range of strategies to implement impedance spectroscopy in 3D systems. This review examines electrode design, integration, and outcomes of a range of impedance spectroscopy studies and multiparametric systems relevant to 3D cell cultures. While these systems provide whole culture data, impedance tomography approaches have shown how this technique can be used to achieve spatial resolution. This review demonstrates how impedance spectroscopy and tomography can be used to provide real‐time sensing in 3D cell cultures, but challenges remain in integrating electrodes without affecting cell culture functionality. If these challenges can be addressed and more realistic electrical models for 3D tissues developed, the implementation of impedance‐based systems will be able to provide real‐time, quantitative tracking of 3D cell culture systems.

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Section: D Impedance Tomographymentioning

confidence: 99%

“…Others have designed similar set ups to those demonstrated in Figure 7, with the eventual aim of monitoring cell cultures, but have not yet tested it using cells (Xu et al, 2018).…”

Section: D Impedance Tomographymentioning

confidence: 99%

Three‐Dimensional (3D) cell culture monitoring: Opportunities and challenges for impedance spectroscopy

León

Pupovac

McArthur

2020

Biotech & Bioengineering

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“…Bioimpedance analysis has been applied in the measurement of body composition and as a measurement tool in healthcare [ 1 ]. Nowadays, there are more uses of bioimpedance techniques in biomedical applications thanks to its low cost, secure handling, and the improvement of electronic components [ 2 , 3 ]. This has motivated many researchers to develop portable and wearable electric bioimpedance measurement systems [ 4 ] for personal and home monitoring [ 5 , 6 , 7 , 8 , 9 ], but whose applications focus on aesthetics, like body composition, rather than physiological aspects [ 1 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Simple Wireless Impedance Pneumography System for Unobtrusive Sensing of Respiration

Aqueveque

Gomez

Monsalve

et al. 2020

Sensors

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This extended paper presents the development and implementation at a prototype level of a wireless, low-cost system for the measurement of the electrical bioimpedance of the chest with two channels using the AD5933 in a bipolar electrode configuration to measure impedance pneumography. The measurement device works for impedance measurements ranging from 1 Ω to 1800 Ω. Fifteen volunteers were measured with the prototype. We found that the left hemithorax has higher impedance compared to the right hemithorax, and the acquired signal presents the phases of the respiratory cycle with variations between 1 Ω, in normal breathing, to 6 Ω in maximum inhalation events. The system can measure the respiratory cycle variations simultaneously in both hemithorax with a mean error of −0.18 ± 1.42 BPM (breaths per minute) in the right hemithorax and −0.52 ± 1.31 BPM for the left hemithorax, constituting a useful device for the breathing rate calculation and possible screening applications.

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“…The first EIT‐based lung image was generated by measuring the potential difference on the human chest. The EIT technology is used in many fields due to its unique advantages, such as the Earth exploration, industrial applications, biomedical imaging, and robotic applications based on artificial sensitive skins in recent years …”

Section: Introductionmentioning

confidence: 99%

Artificial Sensitive Skin for Robotics Based on Electrical Impedance Tomography

Wang

et al. 2020

Advanced Intelligent Systems

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Electrical impedance tomography (EIT) is a noninvasive measurement technique that estimates the internal resistivity distribution based on the boundary voltage–current data measured from the surface of the conductor. If a thin stretchable soft material with a certain piezoresistive property is used as the electrical conductor, EIT has the ability to reconstruct the position where the resistivity changes due to the inside pressure contact, so that a large‐scale artificial sensitive skin is provided for robotics. First, the different conduction principles and material types of artificial sensitive skins are discussed, which is next followed by the different driving modes and image reconstruction techniques. Then, details on how EIT is used for robotic skin applications are described. Finally, the development trends and future potentials of EIT‐based robotic skins are expounded.

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Development of a Portable Electrical Impedance Tomography System for Biomedical Applications

Cited by 78 publications

References 29 publications

Three‐Dimensional (3D) cell culture monitoring: Opportunities and challenges for impedance spectroscopy

Three‐Dimensional (3D) cell culture monitoring: Opportunities and challenges for impedance spectroscopy

Simple Wireless Impedance Pneumography System for Unobtrusive Sensing of Respiration

Artificial Sensitive Skin for Robotics Based on Electrical Impedance Tomography

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