Development of a PET Scanner for Simultaneously Imaging Small Animals with MRI and PET

Thompson, Christopher J.; Goertzen, Andrew L.; Thiessen, Jonathan D.; Bishop, D.; Stortz, Greg; Kozłowski, Piotr; Retière, F.; Zhang, Xuezhu

doi:10.3390/s140814654

Cited by 22 publications

(15 citation statements)

References 27 publications

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“…Moreover, shorter imaging time can greatly accelerate the examination time and reduce the pain of patients [ 4 ]. The performance of a PET system [ 5 , 6 , 7 , 8 , 9 ] directly depends on its components, which include a scintillation crystal, a photodetector, a readout circuit, etc.…”

Section: Introductionmentioning

confidence: 99%

Design and Evaluation of LYSO/SiPM LIGHTENING PET Detector with DTI Sampling Method

Deng

Chen

2020

Sensors

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Positron emission tomography (PET) has a wide range of applications in the treatment and prevention of major diseases owing to its high sensitivity and excellent resolution. However, there is still much room for optimization in the readout circuit and fast pulse sampling to further improve the performance of the PET scanner. In this work, a LIGHTENING® PET detector using a 13 × 13 lutetium-yttrium oxyorthosilicate (LYSO) crystal array read out by a 6 × 6 silicon photomultiplier (SiPM) array was developed. A novel sampling method, referred to as the dual time interval (DTI) method, is therefore proposed to realize digital acquisition of fast scintillation pulse. A semi-cut light guide was designed, which greatly improves the resolution of the edge region of the crystal array. The obtained flood histogram shown that all the 13 × 13 crystal pixels can be clearly discriminated. The optimum operating conditions for the detector were obtained by comparing the flood histogram quality under different experimental conditions. An average energy resolution (FWHM) of 14.3% and coincidence timing resolution (FWHM) of 972 ps were measured. The experimental results demonstrated that the LIGHTENING® PET detector achieves extremely high resolution which is suitable for the development of a high performance time-of-flight PET scanner.

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Section: Introductionmentioning

confidence: 99%

Design and Evaluation of LYSO/SiPM LIGHTENING PET Detector with DTI Sampling Method

Deng

Chen

2020

Sensors

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“…Their application to PET was soon adopted owing to the high gain and timing properties that SiPMs have compared with APDs, 26 still preserving the benefits of APD technology compared with the classical PMT detector. The GE SIGNA PET/MRI scanner 27 and a number of small-animal PET inserts [28][29][30][31] are based on SiPM detectors.…”

Section: Positron Emission Tomography/mri-compatible Photodetector Tementioning

confidence: 99%

Advances in PET/MR instrumentation and image reconstruction

Cabello

Ziegler

2016

The British Journal of Radiology

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The combination of positron emission tomography (PET) and MRI has attracted the attention of researchers in the past approximately 20 years in small-animal imaging and more recently in clinical research. The combination of PET/MRI allows researchers to explore clinical and research questions in a wide number of fields, some of which are briefly mentioned here. An important number of groups have developed different concepts to tackle the problems that PET instrumentation poses to the exposition of electromagnetic fields. We have described most of these research developments in preclinical and clinical experiments, including the few commercial scanners available. From the software perspective, an important number of algorithms have been developed to address the attenuation correction issue and to exploit the possibility that MRI provides for motion correction and quantitative image reconstruction, especially parametric modelling of radiopharmaceutical kinetics. In this work, we give an overview of some exemplar applications of simultaneous PET/MRI, together with technological hardware and software developments.

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“…All three 1 H MR approaches such as 1 H MRS, 1 H MRI and 1 H MRSI have been used to evaluate tumor metabolomics. The MR challenges include combined studies conducted with immunotherapy , chemoradiotherapy (Meng et al, 2014), photothermal/radiotherapy (Wang et al, 2013), simultaneous MRI and Positron Emission Tomography (PET) (Thompson et al, 2014), MRI and Transrectal Ultrasound (TRUS) (GomezIturriaga et al, 2014), PET/MRI and computed tomography (CT) fusion (Miwa et al, 2014). Another aspect in metabolomics is application of 13 C and 19 F MR in research focused on labeling substrates (e.g.…”

Section: Introductionmentioning

confidence: 98%