Advances in PET/MR instrumentation and image reconstruction

Cabello, Jorge; Ziegler, Sibylle

doi:10.1259/bjr.20160363

Cited by 48 publications

(28 citation statements)

References 189 publications

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“…However, the physical combination of PET and MR represents a major technological challenge [45][46][47][48]. Conventional PET systems use PMTs to detect the scintillation light.…”

Section: Pet/mrmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

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“…However, the physical combination of PET and MR represents a major technological challenge [45][46][47][48]. Conventional PET systems use PMTs to detect the scintillation light.…”

Section: Pet/mrmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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“…After solving several technical challenges due to the complexity of integration of PET and MR, the first commercial whole-body PET/MR systems were installed in 2010 [2,3]. PET/MR instrumentation has been an active field and has been discussed in several review articles [4][5][6][7][8][9]. The introduction of simultaneous PET/MR systems for clinical use has been suggested to mark a paradigm shift for neuroimaging, and the combination of both systems offers a multitude of advantages [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance-Based Attenuation Correction and Scatter Correction in Neurological Positron Emission Tomography/Magnetic Resonance Imaging—Current Status With Emerging Applications

Teuho

Torrado‐Carvajal

Herzog³

et al. 2020

Front. Phys.

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In this review, we will summarize the past and current state-of-the-art developments in attenuation and scatter correction approaches for hybrid positron emission tomography (PET) and magnetic resonance (MR) imaging. The current status of the methodological advances for producing accurate attenuation and scatter corrections on PET/MR systems are described, in addition to emerging clinical and research applications. Future prospects and potential applications that benefit from accurate data corrections to improve the quantitative accuracy and clinical applicability of PET/MR are also discussed. Novel clinical and research applications where improved attenuation and scatter correction methods are beneficial are highlighted.

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“…Alternatively, a postreconstruction partial volume correction (PVC) procedure can be used (for reviews, see [83,84]). These techniques are made more accessible by the introduction of multi-modality systems (PET or SPECT combined with CT or MRI), reducing the need for image co-registration (for recent reviews, see [55,[85][86][87]). These techniques also open the door for methods in which PET data are used to improve the quality of MRI images [88].…”

Section: Noise Controlmentioning

confidence: 99%

Advances in clinical molecular imaging instrumentation

Hutton

Erlandsson

Thielemans

2018

Clin Transl Imaging

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In this article, we describe recent developments in the design of both single-photon emission computed tomography (SPECT) and positron emission tomography (PET) instrumentation that have led to the current range of superior performance instruments. The adoption of solid-state technology for either complete detectors [e.g., cadmium zinc telluride (CZT)] or read-out systems that replace photomultiplier tubes [avalanche photodiodes (APD) or silicon photomultipliers (SiPM)] provide the advantage of compact technology, enabling flexible system design. In SPECT, CZT is well suited to multi-radionuclide and kinetic studies. For PET, SiPM technology provides MR compatibility and superior time-of-flight resolution, resulting in improved signal-to-noise ratio. Similar SiPM technology has also been used in the construction of the first SPECT insert for clinical brain SPECT/MRI.

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Advances in PET/MR instrumentation and image reconstruction

Cited by 48 publications

References 189 publications

Hybrid Imaging: Instrumentation and Data Processing

Hybrid Imaging: Instrumentation and Data Processing

Magnetic Resonance-Based Attenuation Correction and Scatter Correction in Neurological Positron Emission Tomography/Magnetic Resonance Imaging—Current Status With Emerging Applications

Advances in clinical molecular imaging instrumentation

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