Advances in clinical molecular imaging instrumentation

Hutton, Brian F.; Erlandsson, Kjell; Thielemans, Kris

doi:10.1007/s40336-018-0264-0

Cited by 57 publications

(37 citation statements)

References 103 publications

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“…Furthermore, in 7 of 20 patients, one or more 18 F-FDG-avid lesions not found on the Biograph mCT images were identified on the Biograph Vision images, a result that could have important clinical consequences. Recent technical developments in PET instrumentation have likely contributed to the improved quality observed in images acquired on the Biograph Vision (23). The introduction of SiPM detectors in commercially available PET/CT systems is of clinical importance because of the potential advantages of this new technology.…”

Section: Discussionmentioning

confidence: 99%

Image Quality and Semiquantitative Measurements on the Biograph Vision PET/CT System: Initial Experiences and Comparison with the Biograph mCT

et al. 2019

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In May 2018, the Biograph Vision PET/CT system was installed at the University Medical Center Groningen. This study evaluated the initial experiences with this new PET/CT system in terms of perceived image quality and semiquantitative analysis in comparison to the Biograph mCT as a reference. Methods: In total, 20 oncologic patients were enrolled and received a single 3 MBq/kg injected dose of 18 F-FDG followed by a dual-imaging PET scan. Ten patients were scanned on the Biograph mCT first, whereas the other 10 patients were scanned on the Biograph Vision first. The locally preferred clinically reconstructed images were blindly reviewed by 3 nuclear medicine physicians and scored (using a Likert scale of 1-5) on tumor lesion demarcation, overall image quality, and image noise. In addition, these clinically reconstructed images were used for semiquantitative analysis by measurement of SUVs in tumor lesions. Images acquired using reconstructions conform with the European Association of Nuclear Medicine Research Ltd. (EARL) specifications were also used for measurements of SUV in tumor lesions and healthy tissues for comparison between systems. Results: The 18 F-FDG dose received by the 14 men and 6 women (age range, 36-84; mean ± SD, 61 ± 16 y) ranged from 145 to 405 MBq (mean ± SD, 268 ± 59.3). Images acquired on the Biograph Vision were scored significantly higher on tumor lesion demarcation, overall image quality, and image noise than images acquired on the Biograph mCT (P , 0.001). The overall interreader agreement showed a Fleiss κ of 0.61 (95% confidence interval, 0.53-0.70). Furthermore, the SUVs in tumor lesions and healthy tissues agreed well (within 95%) between PET/CT systems, particularly when EARL-compliant reconstructions were used on both systems. Conclusion: In this initial study, the Biograph Vision showed improved image quality compared with the Biograph mCT in terms of lesion demarcation, overall image quality, and visually assessed signal-to-noise ratio. The 2 systems are comparable in semiquantitatively assessed image biomarkers in both healthy tissues and tumor lesions. Improved quantitative performance may, however, be feasible using the clinically optimized reconstruction settings.

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Section: Discussionmentioning

confidence: 99%

Image Quality and Semiquantitative Measurements on the Biograph Vision PET/CT System: Initial Experiences and Comparison with the Biograph mCT

et al. 2019

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“…Firstly, if individual SPAD are as sensitive as PMT, SPAD can cover the whole surface of scintillation crystal and the global sensitivity is higher. Secondly, SiPM are faster than PMT, resulting to a time resolution of 215 ps for Siemens Vision PET/CT system ( 9 ). The improvement in time resolution lead to more efficient TOF reconstructions with a very fast convergence and noiseless images ( 10 ) with high effective sensitivity in regards to PMT systems.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Image Quality and Lesion Detectability With Digital PET/CT System

et al. 2021

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Purpose: The aim of this study was to assess image quality and lesion detectability acquired with a digital Positron Emission Tomography/Computed Tomography (PET/CT) Siemens Biograph Vision 600 system.Material and Methods: Consecutive patients who underwent a FDG PET/CT during the first week of use of a digital PET/CT (Siemens Biograph Vision 600) at the nuclear medicine department of the university hospital of Brest were analyzed. PET were realized using list mode acquisition. For all patients, 4 datasets were reconstructed. We determined, according to phantom measurements, an equivalent time acquisition/reconstruction parameters pair of the digital PET/CT corresponding to an analog PET/CT image quality (“analog-like”) as reference dataset. We compared the reference dataset with 3 others digital PET/CT reconstruction parameters, allowing a decrease of emission duration: 60, 90, and 120 s per bed position. Three nuclear medicine physicians evaluated independently, for each dataset, overall image quality [Maximal Intensity Projection (MIP), noise, sharpness] using a 4-point scale. Physicians assessed also lesion detection capability by reporting new visible lesions on each digital datasets with their confidence level in comparison with analog-like dataset.Results: Ninety-eight patients were analyzed. Image quality of MIP (IQMIP), sharpness (IQSHARPNESS), and noise (IQNOISE) of all digital datasets (60, 90, and 120 s) were better than those evaluated with analog-like reconstruction. Moreover, digital PET/CT system improved IQMIP, IQNOISE, and IQSHARPNESS whatever the BMI. Lesion detection capability and confidence level were higher for 60, 90, 120 s per bed position, respectively, than for analog-like images.Conclusion: Our study demonstrated an improvement of image quality and lesion detectability with a digital PET/CT system.

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“…The image quality and also accuracy of data acquisition in nuclear medicine imaging are affected by various components of the imaging chain consisting of collimator and gantry design, physical properties of detector, reconstruction algorithms, attenuation and scatter compensation approaches [1][2][3][4][5]. Employing an appropriate collimator with a certain radiopharmaceutical is a critical factor to create a high quality image [6,7].…”

Section: Introductionmentioning

confidence: 99%

Review on Recent Developments in Collimators of Single Photon Emission Computed Tomography Imaging

Darkhor

Islamian

2020

fbt

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In Single Photon Emission Computed Tomography (SPECT), collimator selection, optimization, and also geometric calibration have a major impact on the acquired image quality and also on an accurate detectability and diagnosis. The collimator optimization phenomena consider some parameters such as field of view, resolution, sensitivity, resolution at depth, septal thickness and penetration for a specific application task. While the parallel hole collimator is usually used in SPECT and planar imaging but due to the limited solid angle covered by the collimator, the system sensitivity and resolution were highly reduced. Meanwhile, other types of collimators such as pin-hole, multi-pin-hole, slant and slit-slat collimators were introduced with a trade-off between sensitivity and resolution. This article reviews improvements on collimators also by considering the geometry and geometric calibration methods for improving the image quality in single photon emission computed tomography.

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Advances in clinical molecular imaging instrumentation

Cited by 57 publications

References 103 publications

Image Quality and Semiquantitative Measurements on the Biograph Vision PET/CT System: Initial Experiences and Comparison with the Biograph mCT

Image Quality and Semiquantitative Measurements on the Biograph Vision PET/CT System: Initial Experiences and Comparison with the Biograph mCT

Assessment of Image Quality and Lesion Detectability With Digital PET/CT System

Review on Recent Developments in Collimators of Single Photon Emission Computed Tomography Imaging

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