Development of a novel therapeutic approach using a retinoic acid-loaded microneedle patch for seborrheic keratosis treatment and safety study in humans

Two‐phase delivery using a horse oil and adenosine‐loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

“…Microneedles have been developed in various fields, such as vaccination, diabetes, keratosis, and aesthetics to deliver active compounds with minimal invasive way . Particularly in the field of cosmetics, solid microneedles (SMNs) have been developed into a roller product to generate microchannels in the skin to increase the absorption of active compounds applied as cream formulations .…”

“…with minimal invasive way. [1][2][3] Particularly in the field of cosmetics, solid microneedles (SMNs) have been developed into a roller product to generate microchannels in the skin to increase the absorption of active compounds applied as cream formulations. 4,5 However, for SMNs, sharp metal or plastic residues cause disposal and reuse problems, leading to safety concerns.…”

Fe3O4/Polycaprolactone Microneedles with Controlled Drug Delivery and Magnetic Hyperthermia

“…Microneedles are microscale projections with the capability of delivering drugs to skin painlessly. [19][20][21] Also, microneedles can be designed to target specific layer of skin. For the treatment of skin cancers, microneedles are possible to arrive at tumor tissues, allowing for enhancing efficacy of therapeutic delivery.…”

“…22 The microneedle patch with biocompatible hyaluronic acid and pH-sensitive dextran nanoparticles can painlessly penetrate the epidermis and become submerged in the interstitial fluid to efficiently deliver aPD1 to the tumor microenvironment, which inhibited tumor growth superior to those obtained with intratumor injection of the same dose. 20 Donnelly et al used silicon microneedle arrays to enhance skin penetration of porphyrin precursor 5-aminolevulinic acid (ALA) for photodynamic therapy, and in vivo experiments showed that microneedle puncture could reduce application time and ALA dose for high levels of the photosensitizer in skin. 23 Recently, Chen et al developed a multifunctional microneedle system with the combination of chemotherapy and photothermal therapy, [24][25] which consists of embeddable polycaprolactone (PCL) microneedles containing a photosensitive lanthanum hexaboride nanoparticles and an anticancer drug DOX.…”

Microneedles from fish scale biopolymer

“…More recently, the focus in the area of microneedle has been to develop biodegradable and non‐toxic polymer microneedles which can be prepared to have sufficiently strong microstructures that can penetrate the skin and deliver active ingredients into the lower layers of the skin and into the body . New developments in this area include microneedles produced from rapidly dissolving silk fibrions and trans retinoic acid loaded microneedles for treatment of seborrheic keratosis . Natural polymers are a preferred choice in contrast to synthetic polymers due to their inexpensive, biodegradable, non toxic nature, and availability .…”