Development of a Novel Polyimide Hollow Fiber for an Intravascular Oxygenator

Kawakami, Hiroyoshi; Mori, Yasumasa; Takagi, Jun; Nagaoka, Shoji; Kanamori, Toshiyuki; Shinbo, Toshio; Kubota, Sunao

doi:10.1097/00002480-199709000-00029

Cited by 20 publications

(17 citation statements)

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“…Polyimides such as poly(ether imide) (PEI) are a new emerging class of polymeric materials for biomedical applications [20,21]. PEI possesses a high thermal and mechanical strength, has excellent membrane forming properties and can be easily modified by wet chemical processes under mild chemical condition [22,23].…”

Section: Introductionmentioning

confidence: 99%

Poly(ether imide) membranes: studies on the effect of surface modification and protein pre-adsorption on endothelial cell adhesion, growth and function

Tzoneva

Seifert

Albrecht

et al. 2008

Journal of Biomaterials Science, Polymer Edition

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Surface modifications of poly(ether imide) (PEI) membranes with carboxylic groups were tested in comparison to pure PEI and poly(ethylene terephtalate) (PET) for their ability to support attachment, growth and function of human umbilical vein endothelial cells (HUVEC) in respect to endothelization of the above materials. Flat sheet PEI membranes were modified by covalent binding of iminodiacetic acid (IDA) for different periods of time (1 to 30 min) to obtain surfaces with various content of carboxylic groups. In addition, fibronectin (FN) and fibrinogen (FNG) preadsorption on the various membranes were studied on their effect on HUVEC behaviour. Results show a decreased protein adsorption and HUVEC adhesion, growth and function in terms of prostacyclin production with an increase carboxylic groups.Preadsorption of the membranes with FN or FNG promoted activity of HUVEC, which became superior to cells on PET. FN-coated membranes were found to be better substrate for HUVEC adhesion and prostacyclin production, while on FNG-coated membranes cells grew better. Overall it can be concluded that PEI is a promising materials for endothelial cells immobilization as it is needed for improving the hemocompatibility of cardiovascular devices.

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Section: Introductionmentioning

confidence: 99%

Poly(ether imide) membranes: studies on the effect of surface modification and protein pre-adsorption on endothelial cell adhesion, growth and function

Tzoneva

Seifert

Albrecht

et al. 2008

Journal of Biomaterials Science, Polymer Edition

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“…11 We have found that the asymmetric fibers show not only a high gas exchange (O 2 transfer and CO 2 removal) but also suppression of platelet adhesion. [12][13][14] However, contact of the blood and membrane material triggers a complex series of events including protein adsorption, leukocyte adhesion and activation, and complement activation.…”

Section: Introductionmentioning

confidence: 78%

Biocompatibility of fluorinated polyimide

Kanno¹,

Kawakami²,

Nagaoka³

et al. 2002

J. Biomed. Mater. Res.

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Contact between blood and biomaterial triggers a complex series of events including protein adsorption, leukocyte adhesion and activation, and complement activation. In this article, a series of fluorinated polyimides cured at a different temperatures was prepared, and the biocompatibility of the membranes was evaluated using in vitro protein adsorption, neutrophil adhesion, and complement activation experiments under static conditions. We found that protein adsorption, neutrophil adhesion, and complement activation for the polyimides significantly depends on the curing temperature and decreases with an increase in the temperature and that the polyimide has a good biocompatibility compared with poly(styrene) and polydimethylsiloxane. We concluded that the rearrangement of molecules such as CF(3), sulfone, and ketone at the outermost surface occurs because of curing, which induces an increase in the hydrophobicity and that the cured polyimide suppresses protein adsorption, neutrophil adhesion, and complement activation because of its high hydrophobicity and low surface free energy.

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“…We believe that aromatic polyimides combine the mechanical and chemical stabilities required for biomedical polymers, although testing under in vivo conditions is needed to confirm the clinical usefulness of implantable devices over a long-term period. Recently, we have reported that a fluorinated aromatic polyimide has attractive properties for membrane fabrication [10,11]. When considering the fact that many medical devices such as dialyzers and oxygenators consist of hollow fiber membranes, the fluorinated aromatic polyimide, which is easily fabricated into the membrane required for biomedical polymers, would offer many possibilities for a novel medical device instead of PDMS.…”

Section: Discussionmentioning

confidence: 99%

Albumin adsorption to surface of annealed fluorinated polyimide

Kawakami

Takahashi

Nagaoka

et al. 2001

Polymers for Advanced Techs

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Albumin adsorption to a surface of fluorinated polyimide which was essentially created only by annealing treatment was investigated. After the polyimide surfaces were annealed, the morphology change of the surface was determined using atomic force microscopy and the surface properties were analyzed by contact angle measurements and X-ray photoelectron spectroscopy. It was found that albumin adsorption on the surface strongly depended on the annealing temperature and time and decreased with annealing. The amount of albumin adsorption to the polyimide annealed at 250°C for 100 hr was six-fold smaller than that of polystyrene and polydimethylsiloxane. A decrease of surface free energy due to a decline in the polar and hydrogen bonding components and an increase in hydrophobicity on the polyimide surface by annealing explain the albumin adsorption results. Annealed Fluorinated Polyimide / 245 FIGURE 2. Amount of adsorbed BSA on polyimide surface at 36.5°C (ionic strength: 0.17, BSA: 1.0 mg/ ml): (a) 6FDA-DDS; (b) 6FDA-6FAP.

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Development of a Novel Polyimide Hollow Fiber for an Intravascular Oxygenator

Cited by 20 publications

References 0 publications

Poly(ether imide) membranes: studies on the effect of surface modification and protein pre-adsorption on endothelial cell adhesion, growth and function

Poly(ether imide) membranes: studies on the effect of surface modification and protein pre-adsorption on endothelial cell adhesion, growth and function

Biocompatibility of fluorinated polyimide

Albumin adsorption to surface of annealed fluorinated polyimide

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