Development of a novel nasal nicotine formulation comprising an optimal pulsatile and sustained plasma nicotine profile for smoking cessation

Cheng, Yunlong; Watts, Peter; Hinchcliffe, Michael; Hotchkiss, Richard M.; Nankervis, R.; Faraj, N F; Smith, Alan M.; Davis, S.S.; Illum, Lisbeth

doi:10.1016/s0168-3659(01)00553-3

Cited by 73 publications

(21 citation statements)

References 14 publications

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“…Sheep make an ideal model for evaluation of nasal delivery of drugs because of their large nares, the anatomical similarity to the human nasal cavity in terms of nasal cavity surface area per kg body weight, easily accessibility of veins for blood sampling, and their mild temperament under experimental conditions. Furthermore, results obtained in the sheep model have been found to correlate well to data obtained in humans (11). Fifteen female sheep (Akkaraman, ∼50 kg) were divided into three groups.…”

Section: Nasal Absorption Of Mtc In Sheep Model Sample Collection Asupporting

confidence: 60%

Nasal administration of metoclopramide from different dosage forms: in vitro, ex vivo, and in vivo evaluation

Taş¹,

Özkan²,

Savaşer³

et al. 2009

Drug Delivery

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Section: Nasal Absorption Of Mtc In Sheep Model Sample Collection Asupporting

confidence: 60%

Nasal administration of metoclopramide from different dosage forms: in vitro, ex vivo, and in vivo evaluation

Taş¹,

Özkan²,

Savaşer³

et al. 2009

Drug Delivery

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“…Due to the volatility and susceptibility to the oxidative degradation of free-base NCT, many researchers have sought an adsorbent material for NCT to prevent evaporation and improve stability. The adsorbents, such as cellulose powder (11), cation exchange resin (12), and magnesium aluminum silicate (13), were employed to carry NCT in powdered form.…”

Section: Introductionmentioning

confidence: 99%

Influence of pH Modifiers and HPMC Viscosity Grades on Nicotine–Magnesium Aluminum Silicate Complex-Loaded Buccal Matrix Tablets

Kanjanabat

2012

AAPS PharmSciTech

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Abstract. Hydroxypropyl methylcellulose (HPMC) tablets containing nicotine-magnesium aluminum silicate (NCT-MAS) complex particles and pH modifiers, namely, sodium chloride, citric acid, and magnesium hydroxide, were prepared using the direct compression method. The effects of HPMC viscosity grades and pH modifiers on NCT release and permeation of the matrix tablets were examined. The results showed that the higher the viscosity grade of HPMC that was used in the tablets, the lower was the unidirectional NCT release rate found. The unidirectional NCT permeation was not affected by the viscosity grade of HPMC because the NCT diffusion through the mucosal membrane was the rate-limiting step of the permeation. Incorporation of magnesium hydroxide could retard NCT release, whereas the enhancement of unidirectional NCT release was found in the tablets containing citric acid. Citric acid could inhibit NCT permeation due to the formation of protonated NCT in the swollen tablets at an acidic pH. Conversely, the NCT permeation rate increased with the use of magnesium hydroxide as a result of the neutral NCT that formed at a basic microenvironmental pH. The swollen HPMC tablets, with or without pH modifiers, gave sufficient adhesion to the mucosal membrane. Furthermore, the addition of magnesium hydroxide to the matrix tablets was the major factor in controlling buccal delivery of NCT. This study suggests that the NCT-MAS complex-loaded HPMC tablets, which contained magnesium hydroxide, are potential buccal delivery systems of NCT.KEY WORDS: buccal tablet; hydroxypropyl methylcellulose; magnesium aluminum silicate; nicotine; pH modifier.

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“…Ion exchangers can be used in a controlled drug release delivery system to exert its unique efficacy. Ion exchangers not only have the sustained release properties themselves, but also provide a better control of drug release through modifier such as coating and gel encapsulation . Eudragit RS series coating materials with the ion‐exchange function have been applied in the development of sigmoidal release system, which can release the drug rapidly with a time lag after the ingestion .…”

Section: Introductionmentioning

confidence: 99%

Loading and Release of Amine Drugs by Ion-Exchange Fibers: Role of Amine Type

Gao

Liu

Yuan

et al. 2014

Journal of Pharmaceutical Sciences

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Development of a novel nasal nicotine formulation comprising an optimal pulsatile and sustained plasma nicotine profile for smoking cessation

Cited by 73 publications

References 14 publications

Nasal administration of metoclopramide from different dosage forms: in vitro, ex vivo, and in vivo evaluation

Nasal administration of metoclopramide from different dosage forms: in vitro, ex vivo, and in vivo evaluation

Influence of pH Modifiers and HPMC Viscosity Grades on Nicotine–Magnesium Aluminum Silicate Complex-Loaded Buccal Matrix Tablets

Loading and Release of Amine Drugs by Ion-Exchange Fibers: Role of Amine Type

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