Development of a novel nano-biomaterial for biomedical applications

Machado, Vagner de Oliveira; Andrade, Ângela Leão; Simon, Alice; Rodríguez-Fernández, Daniel E.; Fabris, José Domingos; Domingues, Rosana Zacarias; Silva, Raphael Ferreira da; Silva, Thamiris Caroline Esteves; Peixoto, Thainá Lopes; Santos, Claudio Teodoro dos; Motta, Adriana Cristina; Duek, Eliana Aparecida de Rezende; Silva, Messias Borges; Gomes, Alaelson Vieira; Cabral, Lúcio Mendes; Carmo, Flávia Almada do; Elias, Carlos Nelson

doi:10.1088/2053-1591/aae11b

Cited by 2 publications

(2 citation statements)

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“…In cancer therapy, the major difficulty is to destroy tumor cells without harming the surrounding normal tissues. One of the ways to get around this problem is protecting magnetic nanoparticles (MNPs) with polymeric coatings to prevent their agglomeration while conferring to the nanocomposite system drug release capabilities [ 1 ]. On the other hand, MNPs can ensure the mobility of the polymeric nanoparticles when a magnetic field is applied, enabling their use for drug release and for treatment by hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, considering the biocompatibility and bioreabsorbability of poly(L-co-D,L acid lactic-co-trimethylene carbonate (PLDLA-co-TMC) and of poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (PEO–PPO–PEO), our research group has reported on the preparation of PLDLA-co-TMC/PEO–PPO–PEO-based nanocomposites incorporating the finasteride drug prepared through the SDM method. Such a composite revealed to be promising as a drug delivery system [ 1 ]. On the other hand, hybrid nanoparticles consisting of MNP cores and PLDLA-co-TMC and PEO–PPO–PEO triblock copolymer shells in different ratios were recently investigated [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Heating Capacity and Biocompatibility of Hybrid Nanoparticles for Magnetic Hyperthermia Treatment

Gomes,

Valverde,

Machado

et al. 2023

IJMS

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Cancer is one of the deadliest diseases worldwide and has been responsible for millions of deaths. However, developing a satisfactory smart multifunctional material combining different strategies to kill cancer cells poses a challenge. This work aims at filling this gap by developing a composite material for cancer treatment through hyperthermia and drug release. With this purpose, magnetic nanoparticles were coated with a polymer matrix consisting of poly (L-co-D,L lactic acid-co-trimethylene carbonate) and a poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblock copolymer. High-resolution transmission electron microscopy and selected area electron diffraction confirmed magnetite to be the only iron oxide in the sample. Cytotoxicity and heat release assays on the hybrid nanoparticles were performed here for the first time. The heat induction results indicate that these new magnetic hybrid nanoparticles are capable of increasing the temperature by more than 5 °C, the minimal temperature rise required for being effectively used in hyperthermia treatments. The biocompatibility assays conducted under different concentrations, in the presence and in the absence of an external alternating current magnetic field, did not reveal any cytotoxicity. Therefore, the overall results indicate that the investigated hybrid nanoparticles have a great potential to be used as carrier systems for cancer treatment by hyperthermia.

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Section: Introductionmentioning

confidence: 99%