Preparation of hybrid nanocomposite particles for medical practices

Machado, Vagner de Oliveira; Andrade, Ângela Leão; Fabris, José Domingos; Freitas, Érico Tadeu Fraga; Ferreira, João; Simon, Alice; Domingues, Rosana Zacarias; Fernandez-Outon, L.E.; Carmo, Flávia Almada do; Souza, Antônio Carlos dos Santos; Saba, Hugo

doi:10.1016/j.colsurfa.2021.126706

Cited by 4 publications

(3 citation statements)

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“…The MNPs were prepared by co-precipitation [ 13 , 14 ]. Briefly, 0.5 mol L −1 solutions of sodium sulfite (10 mmol) and ferric chloride hexahydrate (30 mmol) were mixed in a beaker under mechanical stirring of approximately 800 rpm until the color of the resulting solution changed from dark yellow to light yellow.…”

Section: Methodsmentioning

confidence: 99%

“…Such a composite revealed to be promising as a drug delivery system [ 1 ]. On the other hand, hybrid nanoparticles consisting of MNP cores and PLDLA-co-TMC and PEO–PPO–PEO triblock copolymer shells in different ratios were recently investigated [ 13 , 14 ]. Their extensive physical–chemical characterization enabled electing the most suitable MNP/polymer ratio.…”

Section: Introductionmentioning

confidence: 99%

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Heating Capacity and Biocompatibility of Hybrid Nanoparticles for Magnetic Hyperthermia Treatment

Gomes,

Valverde,

Machado

et al. 2023

IJMS

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Cancer is one of the deadliest diseases worldwide and has been responsible for millions of deaths. However, developing a satisfactory smart multifunctional material combining different strategies to kill cancer cells poses a challenge. This work aims at filling this gap by developing a composite material for cancer treatment through hyperthermia and drug release. With this purpose, magnetic nanoparticles were coated with a polymer matrix consisting of poly (L-co-D,L lactic acid-co-trimethylene carbonate) and a poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblock copolymer. High-resolution transmission electron microscopy and selected area electron diffraction confirmed magnetite to be the only iron oxide in the sample. Cytotoxicity and heat release assays on the hybrid nanoparticles were performed here for the first time. The heat induction results indicate that these new magnetic hybrid nanoparticles are capable of increasing the temperature by more than 5 °C, the minimal temperature rise required for being effectively used in hyperthermia treatments. The biocompatibility assays conducted under different concentrations, in the presence and in the absence of an external alternating current magnetic field, did not reveal any cytotoxicity. Therefore, the overall results indicate that the investigated hybrid nanoparticles have a great potential to be used as carrier systems for cancer treatment by hyperthermia.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Heating Capacity and Biocompatibility of Hybrid Nanoparticles for Magnetic Hyperthermia Treatment

Gomes,

Valverde,

Machado

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…The discussion of radiation effects on polymer composites as the precursors of hybrids, the innovative materials, has opened a large door for the extended applications in several areas of the following activities: modeling [1,2], medicine [3,4], transport [5,6], energy [7,8], electronic devices [9,10], sensors [11,12], food packaging [13,14], building composite materials [15], water desalinization [16] and many others. The inclusion of hybrids through the composite category depends undoubtedly on the deep interpenetration and the specific association of the constituent phases [17]; an explanatory example for the capacity of ionizing radiation for the adjustment of polymer blends into hybrid structuration is the irradiation of chitosan/poly(vinyl alcohol) systems [18].…”

Section: Introductionmentioning

confidence: 99%

Irradiation Effects in Polymer Composites for Their Conversion into Hybrids

Zaharescu

Mariș

2022

J. Compos. Sci.

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In this paper several aspects of profound modifications caused by high energy exposures are presented as possible candidates for the efficient adjusting processing of polymer materials. The class of hybrid composites receives special attention due to the large spectrum of formulations, where the interphase interaction decisively influences the material properties. They represent potential start points for the intimate uniformity of hybrid morphologies. Their radiation processing turns composites onto hybrid morphology with expected features, because the transferred energy is spent for the modification of components and for their compatibility. The essential changes achieved in radiation processed composites explain the new material behavior and durability based on the peculiar restructuring of polymer molecules that occurred in the polymer phase. During high energy irradiation, the interaction between intermediates born in the constitutive phases may convert the primary composites into hybrids, integrating them into large applicability spheres. During the radiation exposure, the resulting hybrids gain a continuous dispersion by means of new chemical bonds. This type of compounds achieves some specific structural modifications in the polymer phase, becoming stable hybrid composites. The functional properties of hybrids definitely influence the material behavior due to the molecular changes based on the structural reasons. The radiolysis of the vulnerable component becomes an appropriate opportunity for the creation of new material with improved stability. The radiation treatment is a proper conversion procedure by which common mixtures may become continuously reorganized. This review presents several examples for the radiation modifications induced by radiation exposure that allow the compatibilization and binding of components as well as the creation of new structures with improved properties. This approach provides the reference patterns for the extension of radiation processing over the well-conducted adjustments of polymer composites, when certain material features are compulsorily required. From this review, several solutions for the adjustment of regular polymer composites into hybrid systems may become conceivable by the extended radiation processing.

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Theranostics and Nanoparticular Approaches for the Treatment of Oral Squamous Cell Carcinoma

Bhattacharya

2022

CCTR

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Oral squamous cell carcinoma (OSCC), one of the most common types of oral cancer, is a significant cause of morbidity and mortality worldwide. OSCC is typically treated with a multidisciplinary approach that includes surgery, chemotherapy, and radiation after a definitive oral cancer diagnosis. Conventional chemotherapy drugs, on the other hand, maybe ineffective and have a variety of side effects. Many techniques for treating and diagnosing various types of oral cancer have been proven and approved, while others are currently being researched in clinical trials. This mini review aimed to explain the current preclinical status of nano-based techniques for diagnosing and treating OSCC successfully. This mini compilation also highlights new theranostics approaches for treating squamous cell carcinoma (OSCC). Cancer biomarker detection has also been improved thanks to nanotechnology, which has made it faster and more sensitive. Various nanoparticles have been used as innovation drivers to overcome these constraints and enhance in-situ drug delivery.

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Preparation of hybrid nanocomposite particles for medical practices

Cited by 4 publications

References 50 publications

Heating Capacity and Biocompatibility of Hybrid Nanoparticles for Magnetic Hyperthermia Treatment

Heating Capacity and Biocompatibility of Hybrid Nanoparticles for Magnetic Hyperthermia Treatment

Irradiation Effects in Polymer Composites for Their Conversion into Hybrids

Theranostics and Nanoparticular Approaches for the Treatment of Oral Squamous Cell Carcinoma

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