Development of a novel fungicide, tolprocarb

Hagiwara, Hiroyuki; Ezaki, Ryutaro; Hamada, Takahiro; Tsuda, Mikio; Ebihara, Koichi

doi:10.1584/jpestics.j19-01

Cited by 12 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Owing to these double modes of action, tolprocarb can efficiently control not only rice blast but also bacterial diseases. 43) Tolprocarb also provides long-term residual activity.…”

Section: Mode Of Action Is Novel or Unknownmentioning

confidence: 99%

Development of novel pesticides in the 21st century

2020

View full text Add to dashboard Cite

General trends and strategies for novel pesticides are summarized. Global pesticide sales and pesticide discovery research are also briefly reviewed. At least 105 chemical pesticides have been launched during the past decade or are under development: 43 fungicides, 34 insecticides/acaricides, 6 nematicides, 21 herbicides, and 1 herbicide safener. Most of them are safe to humans and environmentally friendly. The most developed fungicides are SDHI (succinate dehydrogenase inhibitors), DMI (demethylation inhibitors), QoI (quinone outside inhibitors), and QiI (quinone inside inhibitors). Due to the development of resistance to fungicides with existing modes of action, many fungicides possessing various novel modes of action have been launched or are under development. The trend of insecticide development is changing from organophosphorus, carbamate, and synthetic pyrethroids to nicotinic and diamide insecticides. During the past decade, compounds possessing a variety of novel modes of action have also been launched or are under development. Flupyradifurone and flupyrimin, exhibiting extremely low honeybee toxicity, have been developed and subjected to practical use. Herbicides possessing varied modes of action, such as acetolactate synthase, p-hydroxyphenylpyruvate dioxygenase, protoporphyrinogen oxidase, and very-long-chain fatty acid elongase inhibition, have been developed, but no herbicides possessing a novel mode action have commercialized in nearly 30 years. It is of interest that cyclopyrimorate, which was recently launched, and tetflupyrolimet, which is under development, have novel modes action: homogentisate solanesyltransferase (HST) and dihydroorotate dehydrogenase (DHODH) inhibition, respectively. The development of useful acaricides and nematicides is also progressing. Some natural product origin pesticides are getting attention.

show abstract

“…Owing to these double modes of action, tolprocarb can efficiently control not only rice blast but also bacterial diseases. 43) Tolprocarb also provides long-term residual activity.…”

Section: Mode Of Action Is Novel or Unknownmentioning

confidence: 99%

Development of novel pesticides in the 21st century

2020

View full text Add to dashboard Cite

show abstract

“…3 ). MBIs are classified into three types: MBI-R (tricyclazole, phthalide, and pyroquilon), MBI-D (carpropamid, fenoxanil, and diclocymet), and MBI-P (tolprocarb) (Banba et al, 2017 ; Hagiwara et al, 2019 ; Motoyama & Yamaguchi, 2003 ). The targets of MBI-R, MBI-D, and MBI-P are 1,3,8-THN reductase (3HNR/BUF1), scytalone dehydratase (SDH1/RSY1), and PKS (ALB1), respectively (Fig.…”

Section: Melanin: a Polyketide Compound Required For The Fungal Infec...mentioning

confidence: 99%

Biosynthesis and biological function of secondary metabolites of the rice blast fungus Pyricularia oryzae

Motoyama

Yun

Osada

2021

Journal of Industrial Microbiology and Biotechnology

View full text Add to dashboard Cite

Filamentous fungi have many secondary metabolism genes and produce a wide variety of secondary metabolites with complex and unique structures. However, the role of most secondary metabolites remains unclear. Moreover, most fungal secondary metabolism genes are silent or poorly expressed under laboratory conditions and are difficult to utilize. Pyricularia oryzae, the causal pathogen of rice blast disease, is a well-characterized plant pathogenic fungus. P. oryzae also has a large number of secondary metabolism genes and appears to be a suitable organism for analyzing secondary metabolites. However, in case of this fungus, biosynthetic genes for only four groups of secondary metabolites have been well characterized. Among two of the four groups of secondary metabolites, biosynthetic genes were identified by activating secondary metabolism. These secondary metabolites include melanin, a polyketide compound required for rice infection; tenuazonic acid, a well-known mycotoxin produced by various plant pathogenic fungi and biosynthesized by a unique non-ribosomal peptide synthetase-polyketide synthase hybrid enzyme; nectriapyrones, antibacterial polyketide compounds produced mainly by symbiotic fungi, including plant pathogens and endophytes, and pyriculols, phytotoxic polyketide compounds. This review mainly focuses on the biosynthesis and biological functions of the four groups of P. oryzae secondary metabolites.

show abstract

“…The fungicides having iprovaliacarb act by restricting melanin production of the fungi and stimulating the plant defense mechanism (Hagiwara et al, 2019). Propineb caused enhanced mortality of fungi at higher concentration in-vitro (Everett and Neilson, 1996).…”

Section: In-vivo Evaluation Of Fungicides For the Management Of Red Leaf Spot Of Sorghum Diseasementioning

confidence: 99%

Evaluation of Different Fungicides against Colletotrichum graminicola, the Cause of Red Leaf Spot of Sorghum

Ali¹,

Ali²,

Zeshan³

et al. 2021

PJAR

View full text Add to dashboard Cite

S orghum (Sorghum bicolor L. Moench) serves as food purpose for human beings and animals. It is also useful for manufacturing of beverages which contain alcohol and some biofuels (Amelework et al., 2015). Sorghum has appreciable potential in the food and beverages market because low gluten content makes it more suitable for celiac. It contains phenolics, antioxidants and cholesterol lowering waxes, which are utilized in different industries because it is significant source of nutraceuticals ( John et al., 2006). It is on the 5 th number among all cereal crops with sixty million tons of annual production in the whole world. As Abstract | Sorghum (Sorghum bicolor L. Moench) is a very important cereal crop for human beings and livestock. It is subjected to many diseases in Pakistan like fungal, bacterial, and viral among which the fungal diseases are the most destructive. Colletotrichum graminicola is the causal organism of red leaf spot of sorghum which causes heavy losses to the sorghum crop cultivated in different areas of Pakistan. It produces black anthracnose spots on all the above ground parts especially leaves. In the present study, four fungicides (Aliette, Cabrio Top, Nativo, and Melody Duo) were evaluated against C. graminicola under in-vitro and in-vivo conditions. The poisoned food technique was used for in vitro trials with three concentrations (150 ppm, 200 ppm, and 250 ppm). The most effective concentration of fungicides from laboratory experiment was used in field conditions against red leaf spot of sorghum. Results showed that Cabrio Top was the most effective fungicide by showing 88% fungal inhibition while Native also exhibited good results by showing 78.1% fungal inhibition. The remaining 2 fungicides Melody Duo and Aliette were least effective by showing 48.2% and 37.5% fungal inhibition, respectively. In vivo experiment from all four fungicides, Cabrio Top and Nativo showed best results by controlling 74.57% and 71.52%, respectively disease over control while Melody Duo and Aliette were least effective by controlling 65.31% and 60.08% disease over control. It may be concluded that the Cabrio Top at 250 ppm concentration is the best to manage red leaf spot disease severity under field conditions.

show abstract

Development of a novel fungicide, tolprocarb

Cited by 12 publications

References 18 publications

Development of novel pesticides in the 21st century

Development of novel pesticides in the 21st century

Biosynthesis and biological function of secondary metabolites of the rice blast fungus Pyricularia oryzae

Evaluation of Different Fungicides against Colletotrichum graminicola, the Cause of Red Leaf Spot of Sorghum

Contact Info

Product

Resources

About