Development of a novel chitosan based biocompatible and self-healing hydrogel for controlled release of hydrophilic drug

Sharma, Swati; Kumar, Ashok; Deepak, .; Kumar, Rajesh; Rana, Nishant Kumar; Koch, Biplob

doi:10.1016/j.ijbiomac.2018.05.020

Cited by 55 publications

(26 citation statements)

References 31 publications

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“…The classification of self-healing mechanisms is summarized in Table 2 and is presented in Figure 3. [66,67] Acylhydrazone bonds [68,69] Microcapsule [70,71] Host-guest interactions [72][73][74] Boronate-diol complexation [75,76] Hydrogen bond [77][78][79] Diels-Alder click chemistry [80][81][82] Hydrophobic interactions [83,84] Disulfide bonds [85,86] π-π stacking [87,88] Imine bonds (Schiff base) [89,90] Electrostatic (or ionic) interaction is based on the interaction between ions incorporated into the HG matrix ( Figure 3A). By the mutual attraction of oppositely charged ions or ions and polymer chains, the HG structure can be reconstructed, e.g., between two pieces of HG placed on each other [66].…”

Section: Self-healingmentioning

confidence: 99%

“…The hydrogen atom that is involved in this process must be derived from the hydrogen-high electronegative atom pair, which is usually represented by nitrogen, oxygen, or fluorine atoms [77]. An example of an HG in which this interaction is observed is the structure developed by Sharma et al [78] containing chitosan, which is a donor of hydrogen, and poly-acryloyl-phenylalanine, which is a hydrogen acceptor. No differences were observed between the HG structures before and after healing.…”

Section: Self-healingmentioning

confidence: 99%

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Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Chyzy

Płońska‐Brzezińska

2020

Molecules

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Hydrogels (HGs), as three-dimensional structures, are widely used in modern medicine, including regenerative medicine. The use of HGs in wound treatment and tissue engineering is a rapidly developing sector of medicine. The unique properties of HGs allow researchers to easily modify them to maximize their potential. Herein, we describe the physicochemical properties of HGs, which determine their subsequent applications in regenerative medicine and tissue engineering. Examples of chemical modifications of HGs and their applications are described based on the latest scientific reports.

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Section: Self-healingmentioning

confidence: 99%

Section: Self-healingmentioning

confidence: 99%

Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Chyzy

Płońska‐Brzezińska

2020

Molecules

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“…Chitosan, TC, SGN, and the SGN-TC nanoparticles (F3) were characterized by infrared spectroscopy. Each sample was compressed into a disc with potassium bromide (KBr) then subjected to IR spectroscopy using a Thermo Scientific Nicolet IR 200 spectrometer (Thermo Nicolet, Madison, WI, USA) [34,35]. Each compressed sample was scanned from 4000 cm −1 to 400 cm −1 [36].…”

Section: Infrared (Ir) Spectroscopymentioning

confidence: 99%

Optimization of Thiolated Chitosan Nanoparticles for the Enhancement of in Vivo Hypoglycemic Efficacy of Sitagliptin in Streptozotocin-Induced Diabetic Rats

2020

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Sitagliptin (SGN) is an antidiabetic drug used for treatment of diabetes mellitus type II. The objectives of this study were to formulate SGN in form of thiolated chitosan (TC) nanoparticles to enhance the mucoadhesion properties of SGN to the gastrointestinal tract, prolong drug release, decrease side effects, and enhance patient compliance. Seventeen batches of SGN-TC nanoparticles were designed by Box-Behnken design and prepared using the ionic gelation method using tripolyphosphate (TPP) as crosslinking agent. The prepared formulations were evaluated for particle size, entrapment efficiency %, and in vitro drug release. Based on the results of optimization, three formulations (F1–F3) were prepared with different drug polymer ratios (1:1, 1:2, and 1:3). The mucoadhesion study and in vivo hypoglycemic activity of three formulations were evaluated in comparison to free SGN in streptozotocin (STZ)-induced diabetic rats. The seventeen SGN-TC nanoparticles showed small particle sizes, high entrapment efficiency, and prolonged drug release. The concentration of TC polymers had highest effect on these responses. The percentage of SGN–TC nanoparticles adhered to tissue was increased and the release was prolonged as the concentration of TC polymer increased (F3 > F2 > F1). The hypoglycemic effect of SGN-TC nanoparticles was significantly higher than resulted by free SGN. It was concluded that TC nanoparticles had the ability to enhance the mucoadhesion properties of SGN and prolong the drug release. SGN-TC nanoparticles significantly reduced plasma glucose levels compared to free SGN in STZ-induced diabetic rats.

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“…The researchers believed that they developed hydrogels with good adhesion along with good antimicrobial activity against Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, Candida albicans and Microsporum gypseum [19]. The obtained hydrogels are suitable for biomedicine: they have properties similar to the internal properties of living tissue, moderate mechanical strength and self-healing ability [20].…”

Section: Chemically Crosslinked Hydrogelsmentioning

confidence: 99%

Review of Chitosan Nanomaterials for Metal Cation Adsorption

Piotrowska-Kirschling

Brzeska

2020

PCACD

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Polysaccharides are polymers of long chains of monosaccharide units linked via glycosidic bonds. Starch, cellulose, chitin and their derivatives, such as chitosan, are examples of polysaccharides. Chitin is the second most common natural polysaccharide in the world (after cellulose). Chitin and chitosan are amino polysaccharides. Chitosan is often obtained by chemical, or sometimes enzymatic, deacetylation of chitin. These compounds are increasingly being modified to the nanometric scale. New engineering nanomaterials show better chemical, biological, mechanical, thermal, electrical and sorption properties than the primary materials. In this paper, the methods of chitosan nanomaterials synthesis and their adsorption properties of metal cations are discussed. As it is shown, the selected chitosan nanomaterials have promising adsorption properties of metal cations.

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Development of a novel chitosan based biocompatible and self-healing hydrogel for controlled release of hydrophilic drug

Cited by 55 publications

References 31 publications

Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Optimization of Thiolated Chitosan Nanoparticles for the Enhancement of in Vivo Hypoglycemic Efficacy of Sitagliptin in Streptozotocin-Induced Diabetic Rats

Review of Chitosan Nanomaterials for Metal Cation Adsorption

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