Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Chyzy, Adam; Płońska‐Brzezińska, Marta E.

doi:10.3390/molecules25245795

Cited by 60 publications

(45 citation statements)

References 168 publications

(212 reference statements)

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“…Swelling is a physical process in which a material absorbs liquid, increases in volume and mass while maintaining its shape [ 59 ]. The swelling test results of the matrices based on gelatin, hydroxyethyl cellulose, polyvinylpyrrolidone, and glycerol with the microparticle addition are shown in Figure 5 .…”

Section: Resultsmentioning

confidence: 99%

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Freeze-Dried Matrices Composed of Degradable Polymers with Surfactant-Loaded Microparticles Based on Pectin and Sodium Alginate

Stachowiak

Kowalonek

2021

Materials

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Gelatin/polyvinylpyrrolidone/hydroxyethyl cellulose/glycerol porous matrices with microspheres made of sodium alginate or pectin and sodium alginate were produced. A surfactant was loaded into these microparticles. The microspheres were characterized using optical microscopy, scanning electron microscopy SEM, and laser diffraction particle size analyzer. For the matrices, the density, porosity, swelling capacity, dissolution in phosphate saline buffer were determined and SEM, mechanical, and thermogravimetric studies were applied. The results showed that the size of the two-component microspheres was slightly larger than that of single-ingredient microparticles. The images confirmed the spherical shape of the microparticles. The prepared matrices had high water uptake ability and porosity due to the presence of hydrophilic polymers. The presence of microparticles in the matrices caused a decrease in these parameters. Degradation of the composites with the microspheres was significantly faster than the matrix without them. The addition of microparticles increased the stiffness and toughness of the prepared materials. The efficiency of the thermal decomposition main stage was reduced in the samples with microspheres, whereas a char residue increased in these composites.

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Section: Resultsmentioning

confidence: 99%

“…The new hydrogen bonds are formed between solvent molecules and the functional groups of the polymeric chain. This stabilizes the structure [ 59 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

Freeze-Dried Matrices Composed of Degradable Polymers with Surfactant-Loaded Microparticles Based on Pectin and Sodium Alginate

Stachowiak

Kowalonek

2021

Materials

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“…Hydrogels have been widely applied in the surface modification of 3D-printed titanium alloy implants. When hydrogel is used as a drug carrier, it disseminates drug molecules into surrounding tissues or cells through interconnected pores ( Chyzy and Plonska-Brzezinska, 2020 ). For instance, Zhang W et al (2020) developed a poloxamer 407 hydrogel loaded with simvastatin for filling porous 3D-printed titanium alloy intervertebral cages that achieved stable drug release and significantly promoted bone growth.…”

Section: Surface Modification Technologymentioning

confidence: 99%

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Sheng

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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With the development of three-dimensional (3D) printed technology, 3D printed alloy implants, especially titanium alloy, play a critical role in biomedical fields such as orthopedics and dentistry. However, untreated titanium alloy implants always possess a bioinert surface that prevents the interface osseointegration, which is necessary to perform surface modification to enhance its biological functions. In this article, we discuss the principles and processes of chemical, physical, and biological surface modification technologies on 3D printed titanium alloy implants in detail. Furthermore, the challenges on antibacterial, osteogenesis, and mechanical properties of 3D-printed titanium alloy implants by surface modification are summarized. Future research studies, including the combination of multiple modification technologies or the coordination of the structure and composition of the composite coating are also present. This review provides leading-edge functionalization strategies of the 3D printed titanium alloy implants.

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“…[3] The wound healing process generally consists of four phases: hemostasis and coagulation, inflammation, proliferation, and remodeling. [4] To avoid secondary injury and accelerate wound healing, various dressings including gelatin sponges, Tegaderm TM films, membranes, aerogels, cryogels, modified gauze, bandages, and hydrogels have been designed and developed. [5,6] Traditional wound dressings, DOI: 10.1002/adhm.202101808 such as gauzes and adhesive bandages, could form a physical barrier and absorb exudate while contributing little benefit to the reconstruction of the healing process.…”

Section: Introductionmentioning

confidence: 99%

One‐Step Synthesis of Multifunctional Chitosan Hydrogel for Full‐Thickness Wound Closure and Healing

Guo

Yao

Zhang

et al. 2021

Adv Healthcare Materials

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Multifunctional hydrogel as a sealant or wound dressing with high adhesiveness and excellent antibacterial activity is highly desirable in clinical applications. In this contribution, one-step synthetic hydrogel based on quaternized chitosan (QCS), tannic acid (TA), and ferric iron (Fe(III)) is developed for skin incision closure and Staphylococcus aureus (S. aureus)-infected wound healing. In this hydrogel system, the ionic bonds and hydrogen bonds between QCS and TA form the main backbone of hydrogel, the metal coordination bonds between TA and Fe(III) (catechol-Fe) endow hydrogel with excellent adhesiveness and (near-infrared light) NIR-responsive photothermal property, and these multiple dynamic physical crosslinks enable QCS/TA/Fe hydrogel with flexible self-healing ability and injectability. Moreover, QCS/TA/Fe hydrogel possesses superior antioxidant, anti-inflammatory, hemostasis, and biocompatibility. Also, it is safe for vital organs. The data from the mouse skin incision model and infected full-thickness skin wound model presented the high wound closure effectiveness and acceleration of the wound healing process by this multifunctional hydrogel, highlighting its great potential in wound management.

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Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Cited by 60 publications

References 168 publications

Freeze-Dried Matrices Composed of Degradable Polymers with Surfactant-Loaded Microparticles Based on Pectin and Sodium Alginate

Freeze-Dried Matrices Composed of Degradable Polymers with Surfactant-Loaded Microparticles Based on Pectin and Sodium Alginate

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

One‐Step Synthesis of Multifunctional Chitosan Hydrogel for Full‐Thickness Wound Closure and Healing

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