Development of a novel biomaterial with an important osteoinductive capacity for hard tissue engineering

Simu, Meda-Romana; Páll, Emöke; Radu, Teodora; Miclăuş, Maria; Culic, Bogdan; Mesaroş, Anca; Muntean, Alexandrina; Filip, Gabriela Adriana

doi:10.1016/j.tice.2018.04.004

Cited by 12 publications

(6 citation statements)

References 17 publications

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“…The bulk shell biomineral phase is observed in all shell types and consists of calcite (CaCO 3 ), as revealed by the characteristic Raman bands at 155, 281, 713, and 1086 cm −1 , corresponding to its T, L, ν 4 , and ν 1 (CO 3 2− ) vibrational modes. 18 In crustaceans, the biomineral phase is reinforced by a network of chitin and protein fibers, 10,19,20 which is evidenced in Raman spectra by specific bands, such as that at 953 cm −1 and a series of weaker bands in the 1200−1450 cm −1 range 21,22 and the amide I band of proteins at 1655 cm −1 and in the high wavenumber range at 2878 and 2932 cm −1 , respectively 23 (Figure 3, blue spectra). The differences in intensities of these bands reflect the natural variation of shell composition between the crustacean species.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The waste created by fisheries and seafood industry is becoming an urgent concern, with recent reviews summarizing and calling for improvements in management and reuse technologies. − High contents of valuable biologically synthesized extractable compounds, such as carotenoids, carotenoproteins, proteins, and chitins, are documented in crustacean shells, ,, while their porous architecture is previously observed in various marine species, − although not at the nanoscale spatial resolution. Interestingly, it is still believed that crab shells are exclusively composed from calcite and chitin, although their color is related to the presence of pigments, particularly astaxanthin.…”

Section: Introductionmentioning

confidence: 99%

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From Blue Bioeconomy toward Circular Economy through High-Sensitivity Analytical Research on Waste Blue Crab Shells

Nekvapil

Aluaş²,

Barbu–Tudoran

et al. 2019

ACS Sustainable Chem. Eng.

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Unlike calcite from geological origin, biogenic calcite from marine organisms have gained an increasing interest in the field of advanced materials due to their hierarchical three-dimensional (3D) nanostructure populated with a gradually distributed organic fraction and due to their porosity. Within the blue bioeconomy context, certain seafood species featuring residual biomineral mass ranging from 80 to 95% of the fresh body weight (bivalves, crustaceans, etc.) could be turned into added-value byproducts, provided that the ultrastructure and nanomorphology are preserved as in intact, native materials. Little is known about species-specific nanomorphology and its subtle chemistry when crab shells are exposed to thermal or mechanical stress for any potential waste industrial processing. We probed here the morphology and chemistry preservation in biogenic CaCO 3 from claw shells of two common crustacean species, Callinectes sapidus and Carcinus aestuarii. We found that mechanical powdering results in their carotenoid preservation in micro-and nanosized porous particles with size distributions characteristic for each original color and that their Bouligand-type (twisted plywood) 3D nanomorphology is preserved during thermal treatment. The results suggest that such a waste biomaterial is suitable for potential industrial design steps toward added-value byproducts following the principles of circular economy for a sustainable society.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

From Blue Bioeconomy toward Circular Economy through High-Sensitivity Analytical Research on Waste Blue Crab Shells

Nekvapil

Aluaş²,

Barbu–Tudoran

et al. 2019

ACS Sustainable Chem. Eng.

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“…Biological and mechanical properties and fabrication techniques need to correspond to the bone engineering strategy to achieve an optimal scaffold performance and predictable outcome of therapy [84]. Simu et al found that high viscosity soft propolis extract and shell clam-based biomaterial acts as a suitable scaffold, promoting human stem cells attachment, proliferation, differentiation, and presenting an important osteoinductive effect essential for the mineralized tissue reparation process [85]. Scaffolds are also widely used in regenerative endodontic treatment (RET).…”

Section: Tissue Regeneration Based On Scaffoldsmentioning

confidence: 99%

Mesenchymal Stem Cells Based Treatment in Dental Medicine: A Narrative Review

Smojver¹,

Katalinić²,

Bjelica

et al. 2022

IJMS

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Application of mesenchymal stem cells (MSC) in regenerative therapeutic procedures is becoming an increasingly important topic in medicine. Since the first isolation of dental tissue-derived MSC, there has been an intense investigation on the characteristics and potentials of these cells in regenerative dentistry. Their multidifferentiation potential, self-renewal capacity, and easy accessibility give them a key role in stem cell-based therapy. So far, several different dental stem cell types have been discovered and their potential usage is found in most of the major dental medicine branches. These cells are also researched in multiple fields of medicine for the treatment of degenerative and inflammatory diseases. In this review, we summarized dental MSC sources and analyzed their treatment modalities with particular emphasis on temporomandibular joint osteoarthritis (TMJ OA).

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“…A study characterizing a scaffold of PU incorporating propolis into its fibers showed that the mat increased its hydrophilicity and its fibroblast compatibility and carried out an effective antibacterial activity [65]. A biomaterial based on shell propolis helped human dental stem cells in vitro osteogenic differentiation [69]; future in vivo studies possibly will define it as a suitable material for bioactive cements and for orthopedic material development.…”

Section: Other Scaffoldsmentioning

confidence: 99%

The Potential of Honeybee Products for Biomaterial Applications

Rossi

Marrazzo

2021

Biomimetics

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The development of biomaterials required continuous improvements in their properties for new tissue engineering applications. Implants based on biocompatible materials and biomaterial-based dressings are susceptible to infection threat; moreover, target tissues can suffer injuring inflammation. The inclusion of nature-derived bioactive compounds usually offers a suitable strategy to expand or increase the functional properties of biomaterial scaffolds and can even promote tissue healing. Honey is traditionally known for its healing property and is a mixture of phytochemicals that have a proven reputation as antimicrobial, anti-inflammatory, and antioxidant agents. This review discusses on the potential of honey and other honeybee products for biomaterial improvements. Our study illustrates the available and most recent literature reporting the use of these natural products combined with different polymeric scaffolds, to provide original insights in wound healing and other tissue regenerative approaches.

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Development of a novel biomaterial with an important osteoinductive capacity for hard tissue engineering

Cited by 12 publications

References 17 publications

From Blue Bioeconomy toward Circular Economy through High-Sensitivity Analytical Research on Waste Blue Crab Shells

From Blue Bioeconomy toward Circular Economy through High-Sensitivity Analytical Research on Waste Blue Crab Shells

Mesenchymal Stem Cells Based Treatment in Dental Medicine: A Narrative Review

The Potential of Honeybee Products for Biomaterial Applications

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