Mesenchymal Stem Cells Based Treatment in Dental Medicine: A Narrative Review

Smojver, Igor; Katalinić, Ivan; Bjelica, Roko; Gabrić, Dragana; Matišić, Vid; Molnar, Vilim; Primorac, Dragan

doi:10.3390/ijms23031662

Cited by 26 publications

(23 citation statements)

References 180 publications

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“…The main purpose behind the regenerative endodontic treatment is to regain normal physiological features such as innate immunity, tertiary dentinogenesis, sense of occlusal pressure and pain that the necrotic pulp does not aloud. Three elements are necessary to achieve pulpal regeneration: dental stem cells, biomaterials, and growth factors [38] [39].…”

Section: Action On Dentin-pulp Complexmentioning

confidence: 99%

An Overview of the Use of Medicinal Plants in Regenerative Dentistry

Dhoum¹,

Ibenmoussa²,

Sidqui³

2023

OJST

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Aim: The oral cavity has the particularity to host multiple hard and soft tissues, in this paper, we will discuss the current therapies that lead to cell differentiation by regenerative therapies and the future alternatives proposed by medicinal plants and all the regenerative potential of these different tissues. Material and Methods: A detailed review of the literature through the various search engines: Scopus, PubMed, google scholar, Cochrane, etc., uses the selected keywords to explore the effect of the regenerative potential of several medicinal plants. Results: Through our research, we have proceeded to sort different medicinal plants, according to their repairing and regenerative potential on the different tissues of the oral cavity. Conclusion: Future studies are conceivable to explore the opportunities and potential provided by medicinal plants in the field of regenerative dentistry.

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Section: Action On Dentin-pulp Complexmentioning

confidence: 99%

An Overview of the Use of Medicinal Plants in Regenerative Dentistry

Dhoum¹,

Ibenmoussa²,

Sidqui³

2023

OJST

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“…As with those deriving from other tissue/fluid sources, dental MSCs show self-renewal capacity and multi-differentiation potential and a growing attention is now paid to their characteristics for possible therapeutic applications [ 93 ]. Among the eight types of dental stem cells (DSCs) so far identified, MSCs from dental pulp (DPSCs), human exfoliated deciduous teeth (SHED), and periodontal ligament (PDLSCs) have more extensively been investigated as autologous stem cells to use for regenerative purposes and tissue engineering therapies reviewed by [ 94 ]. Accordingly, the investigation on the purinergic signal has also been performed in these cells.…”

Section: Purinergic Signaling In Teeth and Periodontiummentioning

confidence: 99%

Purinergic Signaling in Oral Tissues

Zuccarini

Giuliani

Ronci

et al. 2022

IJMS

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The role of the purinergic signal has been extensively investigated in many tissues and related organs, including the central and peripheral nervous systems as well as the gastrointestinal, cardiovascular, respiratory, renal, and immune systems. Less attention has been paid to the influence of purines in the oral cavity, which is the first part of the digestive apparatus and also acts as the body’s first antimicrobial barrier. In this review, evidence is provided of the presence and possible physiological role of the purinergic system in the different structures forming the oral cavity including teeth, tongue, hard palate, and soft palate with their annexes such as taste buds, salivary glands, and nervous fibers innervating the oral structures. We also report findings on the involvement of the purinergic signal in pathological conditions affecting the oral apparatus such as Sjögren’s syndrome or following irradiation for the treatment of head and neck cancer, and the use of experimental drugs interfering with the purine system to improve bone healing after damage. Further investigations are required to translate the results obtained so far into the clinical setting in order to pave the way for a wider application of purine-based treatments in oral diseases.

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“…Scaffolds used in RET should not only transport stem cells into the root canal but also regulate the proliferation, differentiation, and metabolism of those stem cells [ 209 ]. The properties of biocompatibility, porosity, mechanical strength, and degradation rate should be considered when selecting a scaffold [ 210 ].…”

Section: The Role Of Scaffolds In Promoting Neural Regenerationmentioning

confidence: 99%

Neural Regeneration in Regenerative Endodontic Treatment: An Overview and Current Trends

Wei

Lyu

et al. 2022

IJMS

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Pulpal and periapical diseases are the most common dental diseases. The traditional treatment is root canal therapy, which achieves satisfactory therapeutic outcomes—especially for mature permanent teeth. Apexification, pulpotomy, and pulp revascularization are common techniques used for immature permanent teeth to accelerate the development of the root. However, there are obstacles to achieving functional pulp regeneration. Recently, two methods have been proposed based on tissue engineering: stem cell transplantation, and cell homing. One of the goals of functional pulp regeneration is to achieve innervation. Nerves play a vital role in dentin formation, nutrition, sensation, and defense in the pulp. Successful neural regeneration faces tough challenges in both animal studies and clinical trials. Investigation of the regeneration and repair of the nerves in the pulp has become a serious undertaking. In this review, we summarize the current understanding of the key stem cells, signaling molecules, and biomaterials that could promote neural regeneration as part of pulp regeneration. We also discuss the challenges in preclinical or clinical neural regeneration applications to guide deep research in the future.

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Mesenchymal Stem Cells Based Treatment in Dental Medicine: A Narrative Review

Cited by 26 publications

References 180 publications

An Overview of the Use of Medicinal Plants in Regenerative Dentistry

An Overview of the Use of Medicinal Plants in Regenerative Dentistry

Purinergic Signaling in Oral Tissues

Neural Regeneration in Regenerative Endodontic Treatment: An Overview and Current Trends

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