Development of a new type of multifunctional fucoidan-based nanoparticles for anticancer drug delivery

Lu, Kun Ying; Li, Rou; Hsu, Chun‐Hua; Lin, Cheng; Chou, Shen Chieh; Tsai, Min Lang; Mi, Fwu Long

doi:10.1016/j.carbpol.2017.02.065

Cited by 129 publications

(60 citation statements)

References 33 publications

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“…The characteristic peaks of the fucoidan spectrum at 1160–1260 and 845 cm −1 were associated with the S=O asymmetric stretching and C–O–S stretching of the sulfate groups (Fig. b) . In the PAH/F nanoparticles' spectrum, both the characteristic peaks of PAH and fucoidan were present.…”

Section: Resultsmentioning

confidence: 92%

“…However, under a reverse operating condition, PAH was added incrementally to the fucoidan solution, causing the formation of a fucoidan‐adsorbed primary layer firstly and a PAH‐adsorbed layer subsequently. The different double layers surrounding the colloidal nanoparticles were responsible for the dispersion or aggregation of PAH/F nanoparticles . The PAH/F nanoparticles were characterized using various physical characterization techniques, such as TEM, FTIR for functional group identification.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to synthetic polymers, various natural polysaccharides have received extensive attention in the fabrication of drug delivery systems, especially nanocarriers, due to tunable electronic architecture and tunable physicochemical attributes. Various polymers include chitosan, alginic acid, cyclodextrin, and fucoidan . The development of drug delivery systems with diversified functions remains as an important direction for the study of functional materials.…”

Section: Introductionmentioning

confidence: 99%

“…Various polymers include chitosan, 4,5 alginic acid, 6,7 cyclodextrin, [8][9][10] and fucoidan. [11][12][13][14] The development of drug delivery systems with diversified functions remains as an important direction for the study of functional materials. In this vein, fucoidan, a natural polysaccharide, is an interesting candidate for biomedical applications because of its promising properties such as biocompatibility and ease of encapsulation of bioactive molecules and less immunogenicity, among others.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Poly‐allylamine hydrochloride and fucoidan‐based self‐assembled polyelectrolyte complex nanoparticles for cancer therapeutics

Wang

Kankala

Chen

et al. 2018

J Biomedical Materials Res

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Herein, we fabricated the novel drug delivery system based on the self‐assembly of two polyelectrolytes, poly‐allylamine hydrochloride (PAH) and fucoidan, as the polycation and polyanion, respectively, under mild conditions for cancer therapeutics. Furthermore, the designed polyelectrolyte complex nanoparticles as well as the methotrexate (MTX) disodium salt‐loaded composites were systematically characterized using various techniques. The MTX loading in the nanoparticles was confirmed by zeta potential values that changed from −36.2 ± 2.2 to −28.3 ± 3.1 mV at a loading amount of 13.3 ± 1.2%. Furthermore, the obtained eventual particle sizes of nanoparticles were various with different concentrations and ratios of polyelectrolytes. The particle size also has increased from 130 ± 2.6 to 162.9 ± 2.3 nm after loading MTX. The drug release investigations in vitro at a pH value of 6.0 (acid environment) showed that the release of MTX was sustained in the conditions provided. Finally, we investigated the anticancer efficacy of MTX‐loaded nanoparticles on MCF‐7 cells and HeLa cells and the satisfactory results were obtained. Together, these self‐assembled PAH/fucoidan nanoparticles with sustained drug release property will become the promising delivery system for cancer therapeutics. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 339–347, 2019.

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Section: Resultsmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Poly‐allylamine hydrochloride and fucoidan‐based self‐assembled polyelectrolyte complex nanoparticles for cancer therapeutics

Wang

Kankala

Chen

et al. 2018

J Biomedical Materials Res

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“…Brown seaweeds are usually grown or collected for food consumption and especially known for their health benefits and high nutritional value, such as kombu or haidai (Laminaria japonica), wakame or quandai-cai (Undaria pinnatifida), hijiki (Hizikia fusiforme), and mozuku (Cladosiphon okamuranus). The major fucoidan yielding brown seaweed genera are Fucus, Sargassum, Laminaria, and Undaria [55].…”

Section: Brown Seaweedsmentioning

confidence: 99%

Antioxidant Activity of Sulfated Seaweeds Polysaccharides by Novel Assisted Extraction

Wu¹

2017

Solubility of Polysaccharides

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Seaweeds have an extremely numerous of species in the world and been able to be divided into several developmental systems. Broadly, three types of seaweeds can be defined according to their color: brown seaweeds, green seaweeds, and red seaweeds. Thousands of years ago, mankind used seaweeds as food and medicine. Seaweed extracts are gaining increasing attention due to their unique composition and the potential for widespread use in industry. A variety of novel (green) extraction techniques have been devised for converting seaweed biomass into seaweed extracts, such as enzyme-assisted extraction (EAE), microwave-assisted extraction (MAE), pressurized liquid extraction (PLE), supercritical fluid extraction (SFE), and ultrasound-assisted extraction (UAE), which are capable of extracting seaweeds' biologically active compounds without causing degradation. Seaweed extracts contain compounds, such as carbohydrates, proteins, minerals, oils, fats, and polyunsaturated fatty acids and abundant bioactive compounds, such as antioxidants, pigments, and sulfated seaweed polysaccharides (SWP), as well as antibacterial, antifungal, anti-inflammatory, antioxidation, antitumor, antiviral, and hypolipidemic effect. The purpose of this article is to describe the antioxidant activity of SWP of brown seaweeds, green seaweeds, and red seaweeds by novel assisted extraction.

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Depolymerizable Enzymatic Cascade Nanoreactor for Self‐Enhancing Targeting Synergistic Tumor Therapy

Song,

Zhao,

Feng

et al. 2024

Adv Funct Materials

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Traditional targeting strategies require nanoparticles (NPs) to penetrate the vascular wall to bind tumor cell surface receptors, resulting in a small proportion of drugs that achieve targeting delivery. Based on this, a novel design of self‐enhancing targeting to tumor vascular sites has been proposed and needs to meet two preconditions: 1) It can efficiently bind to P‐selectin overexpressed by activated tumor vascular endothelial cells. 2) It can release reactive oxygen species (ROS) to the tumor site and activate resting vascular endothelial cells, thus providing more targets for subsequent preparations. Besides, to overcome the limited penetration of the tumor site, a variable‐size system needs to be designed. Red light carbon dots nanozyme (Fe(III)‐CDs) and glucose oxidase (GOx) are combined to form the enzymatic cascade nanoreactor FG. As a natural ligand of P‐selectin, fucoidan (Fu) is coated on the surface of L‐arginine‐composite FG to obtain FGA@Fu. It is demonstrated that FGA@Fu can realize weak acid/photothermal responsive depolymerization to enhance the penetration to tumors with controlled ROS release. Inspiringly, FGA@Fu can achieve “targeting‐activation‐(self‐enhanced targeting)” to tumor vasculature with good fluorescence tracking. In vivo anti‐tumor experiments showed that FGA@Fu has excellent cascade enzyme catalysis/gas/photothermal combination therapy effect and strong inhibition of tumor metastasis.

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Development of a new type of multifunctional fucoidan-based nanoparticles for anticancer drug delivery

Cited by 129 publications

References 33 publications

Poly‐allylamine hydrochloride and fucoidan‐based self‐assembled polyelectrolyte complex nanoparticles for cancer therapeutics

Poly‐allylamine hydrochloride and fucoidan‐based self‐assembled polyelectrolyte complex nanoparticles for cancer therapeutics

Antioxidant Activity of Sulfated Seaweeds Polysaccharides by Novel Assisted Extraction

Depolymerizable Enzymatic Cascade Nanoreactor for Self‐Enhancing Targeting Synergistic Tumor Therapy

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