Development of a new platform for neglected tropical disease surveillance

Lammie, Patrick J.; Moss, Delynn M.; Goodhew, Brook; Hamlin, Katy L.; Krolewiecki, Alejandro; West, Sheila K.; Priest, Jeffrey W.

doi:10.1016/j.ijpara.2012.07.002

Cited by 75 publications

(78 citation statements)

References 21 publications

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“…10 To this end, we included P. falciparum and P. vivax antigens in a serology study that evaluated IgG responses by a multiplex bead assay (MBA), which has been used in other serological studies. [11][12][13] Recombinant antigens included the P. vivax merozoite surface protein 1 19-kDa subunit (P. vivax MSP-1 19 ), the 42-kD subunit of P. falciparum MSP-1 (MSP-1 42 ), and P. falciparum apical membrane antigen 1 (AMA-1).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Immunoglobulin G Responses to Plasmodium falciparum and Plasmodium vivax in Malian School Children Using Multiplex Bead Assay

Rogier¹,

Moss²,

Chard³

et al. 2016

Am J Trop Med Hyg

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Abstract. Malaria serology through assaying for IgG against Plasmodium spp. antigens provides evidence into the infection history for an individual. The multiplex bead assay (MBA) allows for detection of IgG against multiple Plasmodium spp., and can be especially useful in many regions where Plasmodium falciparum is of primary clinical focus, but other species are co-endemic. Dried blood spots were collected from 805 Malian children attending 42 elementary schools in the regions of Mopti, Sikasso, Koulikoro, and Bamako capital district, and IgG assayed by MBA. As southern Mali is known to be holoendemic for P. falciparum, merozoite surface protein 1 19-kDa subunit (MSP-1 42 ) and apical membrane antigen 1 (AMA-1) antigens were included for serology against this parasite. Responses to these antigens both provided high estimates for lifetime exposure, with 730 (90%) children with IgG antibodies for MSP-1 42 , 737 (91%) for AMA-1, and 773 (96%) positive for either or both. Also included was the antigen Plasmodium vivax MSP-1 19 , against which 140 (17.4%) children were found to have antibodies. Increases in antibody titers with older age were clearly seen with the P. falciparum antigens, but not with the P. vivax antigen, likely indicating more of a sporadic, rather than sustained transmission for this species. The MBA provides effective opportunities to evaluate malaria transmission through serological analysis for multiple Plasmodium species.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Immunoglobulin G Responses to Plasmodium falciparum and Plasmodium vivax in Malian School Children Using Multiplex Bead Assay

Rogier¹,

Moss²,

Chard³

et al. 2016

Am J Trop Med Hyg

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“…13,24,25 Including tetanus IgG testing by MBA in national serosurveys can help with monitoring progress towards and maintenance of MNTE. 13 WHO recommends integrating vaccinations given during health service contacts where possible, and opportunities to provide the WHO-recommended TTCV booster doses increasingly exist as countries introduce a second dose of measles-containing vaccine (MCV2) during the second year of life (2YL) and work to develop robust school-based programs for new vaccines that target preadolescents, such as human papillomavirus virus vaccine.…”

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confidence: 99%

Tetanus Immunity Gaps in Children 5–14 Years and Men ≥ 15 Years of Age Revealed by Integrated Disease Serosurveillance in Kenya, Tanzania, and Mozambique

et al. 2016

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Abstract. Recent tetanus cases associated with male circumcision in Eastern and Southern Africa (ESA) prompted an examination of tetanus immunity by age and sex using multiplex serologic data from community surveys in three ESA countries during 2012-2013. Tetanus seroprotection was lower among children 5-14 years versus 1-4 years of age in Kenya (66% versus 90%) and Tanzania (66% versus 89%), but not in Mozambique (91% versus 88%), where children receive two booster doses in school. Among males ≥ 15 years of age, tetanus seroprotection was lower than females in Kenya (45% versus 96%), Tanzania (28% versus 94%), and Mozambique (64% versus 90%). Tetanus immunity from infant vaccination doses wanes over time, and only women of reproductive age routinely receive booster doses. To prevent immunity gaps in older children, adolescents, and adult men, a life-course vaccination strategy is needed to provide the three recommended tetanus booster doses.

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“…By analysing fluctuations in IgG responses to several antigens over time, with multiple blood samples from the same individual, such assays could also define exposure histories. Given the confirmed autochthonous transmission of Zika virus in Haiti and across the Americas, 20 , 43 exposure histories are urgently needed. At a time when funding for the surveillance of a single disease is becoming increasingly difficult to defend, the versatility offered by multiplex bead assays could permit the longitudinal and cost–effective monitoring of multiple pathogens within a single study.…”

Section: Discussionmentioning

confidence: 99%

Measuring Haitian children's exposure to chikungunya, dengue and malaria

Poirier

Moss

Feeser

et al. 2016

Bull. World Health Organ.

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ObjectiveTo differentiate exposure to the newly introduced chikungunya virus from exposure to endemic dengue virus and other pathogens in Haiti.MethodsWe used a multiplex bead assay to detect immunoglobulin G (IgG) responses to a recombinant chikungunya virus antigen, two dengue virus-like particles and three recombinant Plasmodium falciparum antigens. Most (217) of the blood samples investigated were collected longitudinally, from each of 61 children, between 2011 and 2014 but another 127 were collected from a cross-sectional sample of children in 2014.FindingsOf the samples from the longitudinal cohort, none of the 153 collected between 2011 and 2013 but 78.7% (48/61) of those collected in 2014 were positive for IgG responses to the chikungunya virus antigen. In the cross-sectional sample, such responses were detected in 96 (75.6%) of the children and occurred at similar prevalence across all age groups. In the same sample, responses to malarial antigen were only detected in eight children (6.3%) but the prevalence of IgG responses to dengue virus antigens was 60.6% (77/127) overall and increased steadily with age. Spatial analysis indicated that the prevalence of IgG responses to the chikungunya virus and one of the dengue virus-like particles decreased as the sampling site moved away from the city of Léogâne and towards the ocean.ConclusionSerological evidence indicates that there had been a rapid and intense dissemination of chikungunya virus in Haiti. The multiplex bead assay appears to be an appropriate serological platform to monitor the seroprevalence of multiple pathogens simultaneously.

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Development of a new platform for neglected tropical disease surveillance

Cited by 75 publications

References 21 publications

Evaluation of Immunoglobulin G Responses to Plasmodium falciparum and Plasmodium vivax in Malian School Children Using Multiplex Bead Assay

Evaluation of Immunoglobulin G Responses to Plasmodium falciparum and Plasmodium vivax in Malian School Children Using Multiplex Bead Assay

Tetanus Immunity Gaps in Children 5–14 Years and Men ≥ 15 Years of Age Revealed by Integrated Disease Serosurveillance in Kenya, Tanzania, and Mozambique

Measuring Haitian children's exposure to chikungunya, dengue and malaria

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