Development of a new cyano-bonded column for high-performance liquid chromatography

Column Classification and Selection for the Determination of Antibiotics by Micellar Liquid Chromatography

“…2) shows several interesting groupings based on a rescaled distance below 3, for example, C 18 and zorbax columns were grouped together, which is in agreement with the manufacturer's claims. The same conclusions are obtained for C 8 and monolithic columns, which could be attributed to lower SDS sorption because of the higher bonding chain density of the stationary phase used. Amino and phenyl columns are in the same dendrogram group due to the fact that both display similar characteristics (% C load).…”

“…Cyano columns are less commonly used, in part because of concerns about their stability [8] and reproducibility. [9] A common observation is that cyano columns are less retentive (i.e.…”

LC methods for acyclovir and related impurities determination

“…Some of the characteristics according to the manufacturer are the low hydrophobicity for rapid elution of hydrophobic molecules, the retention and separation of strongly basic analytes, the compatibility with highly percent of aqueous mobile phases and its excellent stability and reproducibility. It has been previously described that the properties of the CN columns are governed by the type of cyano phase (trifunctional or monofunctional) on the silica gel support and endcapping [12,13]. Therefore, a very different column was tested.…”

New approaches with two cyano columns to the separation of acetaminophen, phenylephrine, chlorpheniramine and related compounds

“…It has been previously described that the properties of the CN columns are governed by the type of cyano phase (trifunctional or monofunctional) on the silica gel support and endcapping [10,11]. Therefore, a very different column was tested.…”