Development of a nano-zirconia based 68Ge/68Ga generator for biomedical applications

Chakravarty, Rubel; Shukla, Rakesh; Ram, Ramu; Tyagi, A. K.; Dash, Ashutosh; Venkatesh, Meera

doi:10.1016/j.nucmedbio.2010.10.007

Cited by 50 publications

(22 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The eluting medium for the titanium dioxide based 68 Ge/ 68 Ga generator is 0.1 mol L -1 HCl while that of the tin dioxide based generator is 0.6 mol L -1 HCl [22,23]. 68 Ga obtained needs further purification in order to minimize tracer metal impurities that interfere in subsequent radiolabeling [40]. The recommended and routinely adapted elution procedure for 68 Ge/ 68 Ga generator systems from iThemba Labs is fractional elution using 0.6 mol L -1 HCl and its further use for radiolabeling without any purification.…”

Section: Discussionmentioning

confidence: 99%

Preparation and evaluation of a single vial AMBA kit for 68Ga labeling with potential for imaging of GRP receptor-positive cancers

Pandey

Mukherjee

Jindal

et al. 2015

J Radioanal Nucl Chem

Self Cite

View full text Add to dashboard Cite

This study describes the development of a lyophilized kit formulation of AMBA (DO3A-CH 2 CO-G-[4-aminobenzoyl]-QWAVGHLM-NH 2 ), a bombesin analog, for labeling with 68 Ga from an in-house nanoceriapolyacrylonitrile based 68 Ge/ 68 Ga generator and from a commercial 68 Ge/ 68 Ga generator, for imaging the gastrinreleasing peptide (GRP) receptors over-expressed in a variety of human cancers. 68 Ga-AMBA could be prepared in high radiochemical purity (97 ± 1.1 %) and exhibited high in vitro stability. Biodistribution studies in normal Swiss mice showed high pancreatic uptake (15.5 ± 1.5 % ID g -1 ) which reduced in presence of cold peptide (3.5 ± 0.7 % ID g -1 ), confirming the specificity of the 68 Ga-AMBA prepared using the kit to GRP receptors.

show abstract

Section: Discussionmentioning

confidence: 99%

Preparation and evaluation of a single vial AMBA kit for 68Ga labeling with potential for imaging of GRP receptor-positive cancers

Pandey

Mukherjee

Jindal

et al. 2015

J Radioanal Nucl Chem

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the other hand, radioisotope desorption from nanoparticle surface is still the main drawback. Some examples in the literature have exploited this property to produce 68 Ge/ 68 Ga generators, to radiolabel nanoparticles with 69 Ge as well as to radiolabel iron oxide nanoparticles with several radioisotopes, including 68 Ga [8,[66][67][68][69][70].…”

Section: Chelator-free Approachmentioning

confidence: 99%

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

et al. 2018

View full text Add to dashboard Cite

Abstract:The combination of radioisotopes and nanomaterials is creating a new library of tracers for molecular imaging, exploiting the sensitivity of nuclear imaging techniques and the size-dependent properties of nanomaterials. This new approach is expanding the range of applications, including the possibility of theranostics. Among the many different combinations, the use of 68 Ga as the radioisotope in the radio-nanomaterial is particularly convenient. The physicochemical properties of this isotope allow incorporating it into many materials with great chemical flexibility. Furthermore, its production from a benchtop generator eases the preparation of the tracer. Here, we review main results from the last years in which a nanomaterial has been radiolabeled with 68 Ga. In thus process, we pay attention to the use of nanomaterials for biomedical imaging in general and main properties of this radioisotope. We study the main methods to carry out such radiolabeling and the most important applications for molecular imaging.

show abstract

“…129], in construction of a generator column using a nanomaterial [cf . 130] and in retention of the recoiling daughter in an in vivo generator used in alpha radionuclide therapy [cf . 131].…”

Section: Research Orientationsmentioning

confidence: 99%

The present and future of medical radionuclide production

Qaim

2012

Radiochimica Acta

100

View full text Add to dashboard Cite

Reactor and cyclotron production of medical radionuclides / γ -ray emitters for SPECT / Positron emitters for PET / Corpuscular radiation emitters for internal radiotherapy / Low and intermediate energy nuclear reactions / Radionuclide generators / Future directionsSummary. Medical radionuclide production technology is well established. Both reactors and cyclotrons are utilized for production; the positron emitters, however, are produced exclusively using cyclotrons. A brief survey of the production methods of most commonly used diagnostic and therapeutic radionuclides is given. The emerging radionuclides are considered in more detail. They comprise novel positron emitters and therapeutic radionuclides emitting low-range electrons and α-particles. The possible alternative production routes of a few established radionuclides, like 68 Ga and 99m Tc, are discussed. The status of standardisation of production data of the commonly used as well as of some emerging radionuclides is briefly mentioned. Some notions on anticipated future trends in the production and application of radionuclides are considered.

show abstract

Development of a nano-zirconia based 68Ge/68Ga generator for biomedical applications

Cited by 50 publications

References 22 publications

Preparation and evaluation of a single vial AMBA kit for 68Ga labeling with potential for imaging of GRP receptor-positive cancers

Preparation and evaluation of a single vial AMBA kit for 68Ga labeling with potential for imaging of GRP receptor-positive cancers

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

The present and future of medical radionuclide production

Contact Info

Product

Resources

About