Development of a Multimodal Imaging Probe by Encapsulating Iron Oxide Nanoparticles with Functionalized Amphiphiles for Lymph Node Imaging

Yang, Bo; Moon, Seol Ju; Seelam, Sudhakara Reddy; Jeon, Min Jeong; Lee, Yun Sang; Lee, Dong Hoon; Chung, June Key; Kim, Young Il; Jeong, Jae Min

doi:10.2217/nnm.15.41

Cited by 37 publications

(18 citation statements)

References 40 publications

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“…An imaging study with 64 Cu-NOTA-ironoxidemannose ( 64 Cu-NOTA-IO-MAN), a new dual-modality probe yielding superb T2 contrast in MRI (supplemental data; Supplemental Fig. 2), was performed to demonstrate this (27). We chose the lymphatic system as an in vivo model because of its clinical significance, particularly in oncologic studies in which the invasion status of the LN is crucial information for disease stratification, staging, and management (28).…”

Section: Lymph Node (Ln) Imagingmentioning

confidence: 99%

Simultaneous Multiparametric PET/MRI with Silicon Photomultiplier PET and Ultra-High-Field MRI for Small-Animal Imaging

Yoon

Kim

et al. 2016

J Nucl Med

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Visualization of biologic processes at molecular and cellular levels has revolutionized the understanding and treatment of human diseases. However, no single biomedical imaging modality provides complete information, resulting in the emergence of multimodal approaches. Combining state-of-the-art PET and MRI technologies without loss of system performance and overall image quality can provide opportunities for new scientific and clinical innovations. Here, we present a multiparametric PET/MR imager based on a smallanimal dedicated, high-performance, silicon photomultiplier (SiPM) PET system and a 7-T MR scanner. Methods: A SiPM-based PET insert that has the peak sensitivity of 3.4% and center volumetric resolution of 1.92/0.53 mm 3 (filtered backprojection/ordered-subset expectation maximization) was developed. The SiPM PET insert was placed between the mouse body transceiver coil and gradient coil of a 7-T small-animal MRI scanner for simultaneous PET/MRI. Mutual interference between the MRI and SiPM PET systems was evaluated using various MR pulse sequences. A cylindric corn oil phantom was scanned to assess the effects of the SiPM PET on the MR image acquisition. To assess the influence of MRI on the PET imaging functions, several PET performance indicators including scintillation pulse shape, flood image quality, energy spectrum, counting rate, and phantom image quality were evaluated with and without the application of MR pulse sequences. Simultaneous mouse PET/MRI studies were also performed to demonstrate the potential and usefulness of the multiparametric PET/MRI in preclinical applications. Results: Excellent performance and stability of the PET system were demonstrated, and the PET/MRI combination did not result in significant image quality degradation of either modality. Finally, simultaneous PET/MRI studies in mice demonstrated the feasibility of the developed system for evaluating the biochemical and cellular changes in a brain tumor model and facilitating the development of new multimodal imaging probes. Conclusion: We developed a multiparametric imager with high physical performance and good system stability and demonstrated its feasibility for small-animal experiments, suggesting its usefulness for investigating in vivo molecular interactions of metabolites, and cross-validation studies of both PET and MRI.Key Words: PET/MRI; silicon photomultiplier (SiPM); hybrid imaging; multi-parametric imaging; dual-modality imaging probe Asubst antial role of small-animal imaging has been pinpointed in numerous studies in terms of understanding the underlying mechanism of human diseases and elucidating the efficacy of new therapeutic approaches. Among the in vivo small-animal imaging modalities, which are scaled down to dedicated devices from clinical ones, PET is the most-sensitive technique that is readily translatable to the clinic (1). Spatial and temporal distributions of compounds labeled with a positron-emitting radionuclide are noninvasively measured by the PET scanner. Consequently, the PET scanner p...

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Section: Lymph Node (Ln) Imagingmentioning

confidence: 99%

Simultaneous Multiparametric PET/MRI with Silicon Photomultiplier PET and Ultra-High-Field MRI for Small-Animal Imaging

Yoon

Kim

et al. 2016

J Nucl Med

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“…MR imaging studies resulted in uptake by only PSMA positive tumor cells in dual-tumor animal model, which was also confirmed by PET imaging [28]. Another dual-modality imaging probe was devised from the same group for the targeting of lymph nodes, with encapsulation of IONPs in amphiphiles containing NOTA and D-mannose, the specificity of which was confirmed with PET and MR imaging [29]. Graphene oxide (GO) nanosheets were hybridized with 68 Ga-magnetite (Fe3O4) NPs, forming a radiolabeled magnetic graphene oxide (MGO) nanocomposite that can be applied as a drug delivery system.…”

Section: Gallium-68mentioning

confidence: 68%

Radiolabeled Nanoparticles in Nuclear Oncology

2018

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A B S T R A C TDuring recent years, a plethora of pioneering radiolabeled nanoparticles have grown to be an integral part of nuclear medicine as theranostic tools. Herein, we focus on the most representative examples of nanoparticles of the past decade, which have been investigated in conjunction with radioisotopes aiming to serve as drug delivery or imaging agents. The present review highlights the key attributes of each nanosystem and the following classification of radiolabeled nanovehicles is based on increasing mass number (A) of radioisotopic elements.

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“…Yang et al [99] used amphiphile-encapsulated iron oxide nanoparticles, radiolabeled with 68 Ga using NOTA chelate ligand, to monitor lymph node uptake via PET and T2-weighted MR imaging. High radiochemical yield was obtained (<95%) and stability in human serum was tested in human serum by gel filtration at 37 °C, suggesting nanoparticles are stable in human serum under physiological conditions.…”

Section: Iron Oxide Nanoparticles (Ionps)mentioning

confidence: 99%

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

et al. 2018

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Abstract:The combination of radioisotopes and nanomaterials is creating a new library of tracers for molecular imaging, exploiting the sensitivity of nuclear imaging techniques and the size-dependent properties of nanomaterials. This new approach is expanding the range of applications, including the possibility of theranostics. Among the many different combinations, the use of 68 Ga as the radioisotope in the radio-nanomaterial is particularly convenient. The physicochemical properties of this isotope allow incorporating it into many materials with great chemical flexibility. Furthermore, its production from a benchtop generator eases the preparation of the tracer. Here, we review main results from the last years in which a nanomaterial has been radiolabeled with 68 Ga. In thus process, we pay attention to the use of nanomaterials for biomedical imaging in general and main properties of this radioisotope. We study the main methods to carry out such radiolabeling and the most important applications for molecular imaging.

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Development of a Multimodal Imaging Probe by Encapsulating Iron Oxide Nanoparticles with Functionalized Amphiphiles for Lymph Node Imaging

Abstract: We successfully developed PET/MRI dual-modality imaging probe targeting lymph nodes by using the facile encapsulation method.

Cited by 37 publications

References 40 publications

Simultaneous Multiparametric PET/MRI with Silicon Photomultiplier PET and Ultra-High-Field MRI for Small-Animal Imaging

Simultaneous Multiparametric PET/MRI with Silicon Photomultiplier PET and Ultra-High-Field MRI for Small-Animal Imaging

Radiolabeled Nanoparticles in Nuclear Oncology

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

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