Development of a multianalyte optical sol–gel biosensor for medical diagnostic

Oubaha, Mohamed; Gorin, Arnaud; McDonagh, Colette; Duffy, Brendan; Copperwhite, R.

doi:10.1016/j.snb.2015.06.012

Cited by 15 publications

(14 citation statements)

References 18 publications

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“…Combining the plasmonic nanostructures with immunoassays or microarrays offers the unique advantages of detectability, and introduces a wide range of fluorescence-based applications with a large variety of commercially available analytes, as summarized in Table 5. Various detection analytes, including biomarkers, pathogens, and toxins, have been reported in the literature with new detection methodologies and enhanced detection limits to provide a valuable tool for early diagnosis [131,132], point-of-care (POC) diagnosis [133,134], and forensic applications [122,135]. Metallic nanoparticles with a silica spacer and a silica core were reported for quantitative detection of the prostate-specific antigen (PSA) with high sensitivity [133].…”

Section: Metal Enhanced Fluorescence-based Biosensors Applicationsmentioning

confidence: 99%

Recent Developments in Plasmonic Nanostructures for Metal Enhanced Fluorescence-Based Biosensing

Koh²,

et al. 2020

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Metal-enhanced fluorescence (MEF) is a unique phenomenon of surface plasmons, where light interacts with the metallic nanostructures and produces electromagnetic fields to enhance the sensitivity of fluorescence-based detection. In particular, this enhancement in sensing capacity is of importance to many research areas, including medical diagnostics, forensic science, and biotechnology. The article covers the basic mechanism of MEF and recent developments in plasmonic nanostructures fabrication for efficient fluorescence signal enhancement that are critically reviewed. The implications of current fluorescence-based technologies for biosensors are summarized, which are in practice to detect different analytes relevant to food control, medical diagnostics, and forensic science. Furthermore, characteristics of existing fabrication methods have been compared on the basis of their resolution, design flexibility, and throughput. The future projections emphasize exploring the potential of non-conventional materials and hybrid fabrication techniques to further enhance the sensitivity of MEF-based biosensors.

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Section: Metal Enhanced Fluorescence-based Biosensors Applicationsmentioning

confidence: 99%

Recent Developments in Plasmonic Nanostructures for Metal Enhanced Fluorescence-Based Biosensing

Koh²,

et al. 2020

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“…Examples of high refractive index films deposited by ALD for the fabrication of biosensors are presented in Table 5. Recently, Oubaha et al deposited a Ta2O5 layer by ALD to increase the sensing properties of a multianalyte biosensor (Oubaha et al, 2015). Ta2O5 was chosen due to its high refractive index, which increases the intensity of the evanescent field (EF) by 440 times when compared to the system without the high refractive index layer (HRIL).…”

Section: Materials With High Refractive Indexmentioning

confidence: 99%

Atomic layer deposition for biosensing applications

Graniel

Weber

Balme

et al. 2018

Biosensors and Bioelectronics

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Atomic layer deposition (ALD) is a thin film deposition technique currently used in various nanofabrication processes for microelectronic applications. The ability to coat high aspect ratio structures with a wide range of materials, the excellent conformality, and the exquisite thickness control have made ALD an essential tool for the fabrication of many devices, including biosensors. This mini-review aims to provide a summary of the different ways ALD has been used to prepare biosensor devices. The materials that have been deposited by ALD, the use of the ALD layers prepared and the different types of biosensors fabricated are presented. A selected list of studies will be used to illustrate how the ALD route can be implemented to improve the operational performance of biosensors. This work comprehensively shows the benefits of ALD and its application in various facets of biosensing and will help in exploiting the numerous prospects of this emerging and growing field.

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“…In addition to their capability to form three-dimensional inorganic networks, these precursors can provide functional groups at the surface of the coatings. For example, mercaptosilanes have been used to functionalise glass surfaces for the immobilisation of biological species [8], epoxysilanes have been employed to improve the adhesion properties of organic coatings [9] and acryloxysilanes have been used to provide photoreactivity for the fabrication of miniature devices [10] and microstructuring of optical devices [11]. Second, these organosilane sol-gel matrices are capable of hosting organic and inorganic doping elements to further provide desirable characteristics for specific applications.…”

Section: Introductionmentioning

confidence: 99%

The role of the hydrolysis and zirconium concentration on the structure and anticorrosion performances of a hybrid silicate sol-gel coating

Cullen

O’Sullivan

Kumar

et al. 2018

J Sol-Gel Sci Technol

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In sol-gel chemistry, hydrolysis is the key step in the formation of the reactive hydroxide groups that are responsible for the formation of inorganic networks via the occurrence of condensation reactions. Though previous studies have investigated the effect of the hydrolysis conditions on the structure of organically modified silicates (ormosils), no study, to our knowledge, has investigated this variable on the structure of hybrid materials prepared by combinations of an ormosil and a transition metal (TM). Here, we propose to investigate this effect in a hybrid material composed of 3-trimethoxysilylpropylmethacrylate and a zirconium complex. To also highlight the effects of the precursor's concentrations on the hydrolysis and condensation reactions of the hybrid materials, their relative content was altered along with the hydrolysis degree. The anticorrosion barrier properties were identified by characterisation of coatings deposited on AA2024-T3 substrates and correlation between the structure and the anticorrosion properties of the coatings were performed based on results obtained from structural characterisations (DLS, FTIR, 29 Si-NMR, DSC, AFM and SEM) and corrosion testing (EIS and NSS). It is demonstrated that competition in the formation of siloxane and Si-O-Zr bonds takes place and can be controlled by the degree of hydrolysis and the concentration of the zirconium complex. This effect was found to dramatically alter the morphology of the coatings and their subsequent anticorrosion performances. At shortterm exposure times, it is found that the most condensed materials exhibited a higher corrosion resistance while over longer periods the performances were found to level. This article highlighted the critical impact of the hydrolysis degree and zirconium concentration on the connectivity of hybrid sol-gel coatings and the impact this has on corrosion performances.

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Development of a multianalyte optical sol–gel biosensor for medical diagnostic

Cited by 15 publications

References 18 publications

Recent Developments in Plasmonic Nanostructures for Metal Enhanced Fluorescence-Based Biosensing

Recent Developments in Plasmonic Nanostructures for Metal Enhanced Fluorescence-Based Biosensing

Atomic layer deposition for biosensing applications

The role of the hydrolysis and zirconium concentration on the structure and anticorrosion performances of a hybrid silicate sol-gel coating

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